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Research at Mass General
Principal Investigator, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital
Associate Professor of Medicine, Harvard Medical School
Antibodies are the preeminent effector proteins of the immune system. The bimodal activity of antibodies allows simultaneous recognition of antigen (by the antigen-binding fragment, Fab) with high affinity, and recruitment and activation of leukocytes through interactions between the constant, crystallizable fragment (Fc) and Fc receptors (FcRs) expressed by innate immune cells. Studies have demonstrated that antibody glycosylation is an important regulator of Fc-FcR interactions. Our laboratory is particularly interested in the role and regulation of IgE and IgG glycosylation in health and disease.
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