Hair Academic Innovative Research Unit

Our unit conducts clinical research related to hair loss.

Overview


Welcome to the website for the laboratory of Dr. Maryanne Makredes Senna at the Department of Dermatology at Massachusetts General Hospital. Our unit conducts clinical research related to hair loss including research on the causes, prevention, evaluation and management of diseases that affect hair, both in adolescents and adults.

We also invite collaborators from industry, research and academia interested in hair loss diseases to get in touch by emailing HAIR@partners.org.

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Our Team

Meet Our Team

M.Senna Maryanne M. Senna, MD
Principal Investigator
Dr. Senna, co-director of the Hair Loss Clinic is a board-certified dermatologist who specializes in the diagnosis and treatment of hair loss. In addition to treating patients for hair loss: she is developing a specialized Alopecia Research Unit to identify new treatment methods.  Diagnosed herself with alopecia in the past, Dr. Senna has personal insight and empathy for her patients.     


Mariko YasudaMariko Yasuda, MD
Investigator
Dr. Yasuda, co-director of the Hair Loss Clinic is a board certified dermatologist and dermatopathologist who specializes in the diagnosis and treatment of hair loss. In addition to her clinical skills, Dr. Yasuda has additional expertise in interpreting scalp biopsy specimens in patients who have alopecia.


Lynn A. Drake, MD
Investigator
Dr. Drake is a world-renown expert and lecturer on hair loss who provides additional consultations.


JPJean-Phillip Okhovat, MD, MPH
Alopecia Clinical and Research Fellow
Dr. Okhovat is a clinical and research fellow dedicated to studying hair loss disorders. In addition to helping to diagnose and treat patients, he is actively engaged in conducting epidemiological research to better understand and treat hair loss disorders and develop new therapies. 


tinaDina Hagigeorges
Clinical Research Coordinator
As a coordinator in the H. A. I. R Unit, Dina is passionate about bringing quality care to patients with hair disorders.  She is also a coordinator for the Scalp Cooling Project at Mass General (MGH), a joint venture between the MGH Hair Loss Clinic and MGH Breast Oncology Department. 


athenaAthena Manatis-Lornell
Clinical Research Coordinator
Athena Manatis-Lornell is the coordinator for the H.A.I.R. Unit. With a background in project management and an interest in clinical research, Athena is responsible for organizing the set up of studies and aiding in their implementation.


DustinDustin H. Marks, BS
Alopecia Graduate Assistant (Medical Student)
Currently on a research gap year from medical school, Dustin is truly thrilled to be part of the H.A.I.R team at MGH. With a passion for both public health and dermatology, he is particularly interested in investigating the impact of race, gender, and socioeconomic status on the development, manifestation, and treatment of dermatologic and hair disorders.


 

 

Research Publications

Selected Publications

 1.   Tan S & Senna MM. Hair and Nail Manifestations of Systemic Disease. Curr Derm Rep (2017).
 2.  Xu L, Liu KX, Senna MM. A Practical Approach to the Diagnosis and Management of Hair Loss in Children & Adolescents , Front Med, 24 July 2017
 3.  Penzi LR, Manatis-Lornell AJ, Saavedra A, Fisher D, Senna MM. Hair repigmentation associated with use of Brentuximab. JAAD Case Reports 2017; 3: 563-5.
 4.  Manatis-Lornell AJ, Nikolskaia OV, Senna MM. Facial Papules in a Patient with Lichen Planopilaris. JAMA Dermatology. January 3, 2018. doi:10.1001/jamadermatol.2017.5291
 5.  Penzi LR, Manatis-Lornell AJ, Saavedra AS, Senna MM.  Long-standing Pili Torti in Two Patients with Chronic Graft Versus Host Disease. JAAD Case Reports 2018 Jan; 4(1): 44–46.
 6.  Azzawi S, Penzi LR, Senna MM. Immune Privilege Collapse and Alopecia Development: Is Stress a Factor?  Skin Appendage Disorders. 2017 December 20. doi: 10.1159/000485080
 7.  Rajabi F, Drake LA, Senna MM, Rezai N. Alopecia Areata: a review of disease pathogenesis. Br J Dermatol.  2018 May 23. doi: 10.1111/bjd.16808.
 8.  Naftulin JS, Penzi LR, Manatis-Lornell AJ, Yasuda MY, Porter ML, Saavedra A, Senna MM. Longstanding alopecia and nail dystrophy are associated with more severe overall chronic graft-versus-host disease in adults. Bone Marrow Transpl. 2018 Sept. doi: 10.1038/s41409-018-0309-z.
 9.  Penzi LR, Yasuda M, Manatis-Lornell A, Hagigeorges D, Senna MM. Hair Regrowth in a Patient With Long-standing Alopecia Totalis and Atopic Dermatitis Treated With Dupilumab. JAMA Dermatol. 2018 Oct 10. doi: 10.1001/jamadermatol.2018.2976 [EPub ahead of print]
 

 

Research Presented at Professional Meetings

 1.  Penzi LR, Manatis-Lornell AJ, Senna MM. Retrospective review of stress as a trigger for hair loss in patients diagnosed with alopecia areata seen in a specialty alopecia clinic. The 10th World Congress for Hair Research. Kyoto, Japan, November 1-4, 2017 
 2.  Porter M, Penzi LR, Manatis-Lornell AJ, Senna MM. Retrospective review of triggers, demographics, and stress of patients diagnosed with telogen effluvium at a specialty alopecia clinic. Selected for oral presentation. The 10th World Congress for Hair Research. Kyoto, Japan, November 1-4, 2017.
3. Manatis-Lornell AJ, Porter M, Yasuda MR, Senna MM. Histopathological and Immunohistochemical Assessment of Patients with Lichen Planopilaris and Frontal Fibrosing Alopecia. The 10th World Congress for Hair Research. Kyoto, Japan, November 1-4, 2017.
4. Manatis-Lornell AJ, Porter M, Yasuda MR, Drake L, Senna MM.  The use of a target area in measuring disease activity in patients with lichen planopilaris. The 10th World Congress for Hair Research. Kyoto, Japan, November 1-4, 2017.
5.  Penzi LR, Porter M, Manatis-Lornell AJ, Senna MM. Hair disorders associated with autoimmune connective tissue diseases. Selected for oral presentation. The American Academy of Dermatology Annual Meeting, San Diego, CA. February 16, 2018.
6. Naftulin JS, Manatis-Lornell AJ, Penzi LR, Yasuda MR, Saavedra A, Senna MM. Categorization of long lasting hair changes in patients after hematopoietic stem cell transplant. Selected for oral presentation. The American Academy of Dermatology Annual Meeting, San Diego, CA. February 16, 2018.
7. Manatis-Lornell AJ, Penzi LR, Hagigeorges D, Yasuda MR, Senna MM. Patient Reported Stress Caused by Hair Loss Using A Numeric Rating Scale. The American Hair Research Society Summit Meeting, Orlando, FL. May 14-16, 2018.
8. Penzi LR, Manatis-Lornell AJ, Hagigeorges D, Yasuda MR, Senna MM. A Case Series of Spironolactone as An Effective Treatment for Female Pattern Hair Loss. The American Hair Research Society Summit Meeting, Orlando, FL. May 14-16, 2018
9.

Hagigeorges D, Penzi LR, Manatis-Lornell AJ, Yasuda MR, Senna MM. The Prevalence of Misdiagnosis of Scarring Alopecia from A Facebook Scarring Alopecia Support Group Member Survey. The American Hair Research Society Summit Meeting, Orlando, FL. May 14-16, 2018.



 

Contact Us

H.A.I.R.
Hair Academic Research Unit

Maryanne M. Senna, MD
Principle Investigator

Please email us HAIR@partners.org for more information on potential projects or with any questions. We also invite you to visit the Massachusetts General Hospital Hair Loss Clinic website.

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