Laboratory for Deep Neurophenotyping: Anoopum Gupta, MD, PhD

Our mission is to drive the development of new mechanism-driven therapies through a richer understanding of how neurologic disease affects behavior.

About Us

We are a group of neurologists and computer scientists who share the passion for using technology to precisely understand how certain neurologic diseases impact human motor and cognitive function. We believe that capturing high-definition behavior at scale will lead to the discovery of fundamental characteristics of disease that will inform new approaches to therapy development, diagnosis, and management. Our initial focus is on cerebellar ataxia, Parkinson’s disease, and neurodegenerative disease in general.

We are deeply thankful to the patients and patient advocates who donate their time to our research program during their visit to MGH. Likewise, this work would not be possible without the generous support from the Ataxia-Telangiectasia Children’s Project (A-TCP) and the MGH Department of Neurology.


Group Members

Anoopum Gupta, MD, PhD

Assistant in Neurology, Massachusetts General Hospital
Instructor in Neurology, Harvard Medical School

Anoopum Gupta received his undergraduate degree in Electrical Engineering from Georgia Tech, his medical degree from the University of Pittsburgh School of Medicine, and his PhD in Robotics and the Center for the Neural Basis of Cognition from Carnegie Mellon University’s School of Computer Science. He completed his residency in neurology at the Partners-Harvard Neurology Residency Program (MGH and Brigham and Women’s Hospital).

Dr. Gupta’s previous research utilized methods in machine learning and signal processing to understand how large populations of neurons in the hippocampus support learning, memory, and decision making.

Mary Donovan, Clinical Research Coordinator, Massachusetts General Hospital and Harvard Medical School


  • Zhuoqing (George) Chang, PhD student in Electrical and Computer Engineering, Duke University
  • Krzysztof Gajos, PhD, Gordon McKay Professor of Computer Science at the Harvard Paulson School of Engineering and Applied Sciences, Harvard University
  • Albert Hung, MD, PhD, Assistant Professor of Neurology, Massachusetts General Hospital and Harvard Medical School
  • Guillermo Sapiro, PhD, Edmund T. Pratt, Jr. School Professor of Electrical and Computer Engineering, Duke University
  • Jeremy Schmahmann, MD, Professor of Neurology, Massachusetts General Hospital and Harvard Medical School
  • Pavan Vaswani, MD, PhD, Neurology Resident, Massachusetts General Hospital, Brigham and Women’s Hospital, and Harvard Medical School

Research Positions

We are always looking for individuals with a strong quantitative and algorithmic background as well as a passion for understanding the brain and neurologic disease to lead areas of interest within our group.

Contact Us

Laboratory for Deep Neurophenotyping
50 Staniford Street, 4th Floor
Boston, MA 02114


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