The Jaffer Lab

Jaffer Lab: Farouc Jaffer, MD, PhD

The Jaffer Lab at Massachusetts General Hospital is developing new approaches to image high-risk plaques (narrowings, blockages) that cause myocardial infarction (heart attacks), which could ultimately help prevent heart attacks from occurring.

Overview

The laboratory of Farouc Jaffer, MD, PhD, in the Cardiovascular Research Center at Massachusetts General Hospital is developing bench-to-bedside approaches to image and understand in vivo inflammation and thrombogenesis in vascular disease, including atherosclerosis, venous thrombosis, and arteriovenous fistula. 

Through close collaborations with molecular imaging chemistry experts, we have developed an array of molecular imaging agents to report on macrophages, fibrin, cathepsin K, VCAM-1, thrombin, and activated factor XIII. Using intravital microscopy, FMT, MRI or PET-CT, we have imaged and quantified these molecular targets in murine models of vascular disease, which have led to new insights into how atheroma, thrombi, and AVF evolve and resolve.

Our major translational efforts focus on developing intravascular near-infrared fluorescence molecular imaging catheter technology to image inflammation in human coronary arteries and coronary stents, using large animal models. In conjunction with world-leading engineering groups, we have developed intravascular NIRF-OCT and NIRF-IVUS catheters and systems. The ability to image inflammation at high-resolution could provide new approaches to identify high-risk plaques and high-risk stents.

Our clinical research efforts focus on improving percutaneous coronary intervention success for chronic total occlusions, radial artery catheterization, and improving the treatment of microvascular coronary disease and microvascular angina.

Group Members

Principal Investigator

Farouc Jaffer MD, PhD
Director, Coronary Intervention, Massachusetts General Hospital
Director, Mass General Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI) program
Associate Physician, Mass General Cardiology, Department of Medicine


Post-Doctoral Fellows

Daqing Li, MD, Post-doctoral Fellow (2017-present)
Research: NIRAF-OCT of plaque progression.


Mohammed Chowdhury, MB, ChB,
Post-doctoral Fellow (2017-present) 
Research: Molecular imaging of balloon injury and inflammation.

 

 

 

  • BHF CRT Fellowship Recipient (2016-2019)
  • Parke-Davies Exchange Fellowship Recipient - University of Cambridge (2017-2018)
  • Royal College of Surgeons of England Research Fellowship Recipient: Royal Arch Freemasons' Award (2015-2016)
  • Papers published in European Journal of Vascular and Endovascular Surgery, Angiology, Journal of Vascular Surgery, PLoS One, Current Cardiovascular Imaging Reports, Methods in Molecular Biology, Current Atherosclerosis Reports, Cochrane Database Systematic Reviews (Cochrane Vascular) and Journal of American College of Cardiology

Mazen Albaghdadi, MD, MSc, Post-Doctoral Fellow (2017-present);Graduate Assistant, Interventional Cardiology, Massachusetts General Hospital (2015-present)

Research: Molecular imaging of inflammation in cardiovascular disease and medical device development.

  • Recipient NIH T32 Postdoctoral fellowship (2018)
  • NIH F32 Fellowship (2013-2015)
  • Papers published in Journal of the American Heart Association, Advanced Materials Technologies, Vascular Medicine, Frontiers in Cardiovascular Medicine, PLoS One, Magnetic Resonance Medicine and European Heart Journal

Xiaoxin Zheng, MD, PhD, Post-doctoral Fellow (2017-present)
Research: Molecular imaging of stent thrombosis.


Wenzhu Li, MD, Post-doctoral Fellow (2016-present) 
Research: Molecular imaging of venous thrombosis resolution and mechanisms of fibrinolysis.

  • National Nature Science Foundation of China for Young Scholar
  • Chinese Scholarship Council Fellowship Recipient

Stephan Kellnberger, PhD

Stephan Kellnberger, PhD, Post-doctoral Fellow (2014-present)
Research: Molecular Thermo-acoustic imaging and Intravascular NIRF-IVUS imaging (Co-advisor Vasilis Ntziachristos, PhD).

 

 

 

  • AHA Fellowship Recipient (2017)
  • Feodor Lynen Postdoctoral Research Fellowship Recipient (2014-2016)
  • Papers published in Physical Review Letters, Nature - Scientific Reports, Optics Letters, Applied Physics Letters, and Physics in Medicine and Biology

Eric Osborn

Eric Osborn, MD, PhD,
Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2013-present)
Research: Molecular imaging of atherosclerosis and stent injury.

 

 

  • Recipient NIH T32 Postdoctoral fellowship (2013)
  • Recipient Harvard Catalyst KL2 Award (2013-2015)
  • NIH Loan Repayment Recipient (2014-2016)
  • Papers published in the Journal of the American College of Cardiology:  Cardiovascular Imaging (3), European Heart Journal:  Cardiovascular Imaging, Current Atherosclerosis Reports, and the International Journal of Cardiovascular Imaging
  • Two manuscripts in preparation

Jie Cui, MD, Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2014-present)
Research: Imaging of inflammation and thrombosis in arteriovenous fistula.

  • Recipient George B. Rathmann Research Fellowship, American Society of Nephrology (2013-2015)
  • Abstract presentation, ATVB 2013, WMIC 2013, ASN 2013, ASN 2014
  • 1 manuscript published in Arteriosclerosis, Thrombosis, and Vascular Biology

Chase Kessinger, PhD, Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2016-Present)
Research: The role of inflammation in thrombus resolution.

  • NIH T32 fellowship recipient (2010-2013)
  • NIH Diversity supplement for HL122388 
  • Abstract Presentations, World Molecular Imaging Congress 2011, 2016, ATVB 2012 and 2013 (oral presentation) 2014 (poster), World Molecular Imaging Congress 2012 – winner 1stplace poster award
  • Oral presentation, SVS 2017
  • Manuscripts published in the Journal of American College of Cardiology:  Cardiovascular Imaging, Arteriosclerosis Thrombosis & Vascular BiologyMolecular Imaging and Biology, Cell Metabolism, Circulation, PLOS One, and Theranostics
  • Two manuscripts in preparation 

Lab Manager

Adam Mauskapf, BS,
Lab Manager (2008-Present)

Adam Mauskapf has been the lab manager for the Jaffer Lab since 2012, and has been with the lab since 2008. He graduated from Bucknell University in 2007. He helps to run the large and small animal research labs and is the research surgeon for the large animal lab. Adam helps to manage the lab, set up surgery schedules, and do many other technical tasks. He has experience in catheterization techniques, micro- and macro-surgery, animal care, anesthesia monitoring, and other aspects of animal research.


Clinical Research Coordinator

Patricia Giunta, BA,
Clinical Research Coordinator

Patricia Giunta is the Clinical Research Coordinator for Dr. Jaffer’s clinical imaging and interventional research program. She recruits patients into studies and specifically assist in performing novel fusion of CT and X-ray imaging technology to guide complex coronary interventions. She received a Bachelor of Arts from McGill University in Italian and German Literature and a Master of Arts from the University of Notre Dame in Italian Literature. She is now studying science and planning to apply to medical school in the next year.


Research Technician

Madeleine Grau, BS, Research Technician (2017-Present)


Alumni

Purvish Patel, BS, Graduate Student (2006-2008)


Kiyuk Chang, MD, PhD, Associate Professor of Medicine, Catholic University, Seoul, Korea (2007-2009)

  • Published 2 manuscripts, including 1 in Arteriosclerosis Thrombosis & Vascular Biology
  • Young Investigator Award, ATVB Council, AHA Scientific Sessions (2008)

Ion Botnaru, MD, Cardiologist, Olympia, Washington (2008-2010)  

  • 1 paper published in Science Translational MedicineNanomedicine, and Bioconjugate Chemistry

Amit Saxena, PhD, Post-doctoral fellow, Albert Einstein University (2008-2010)  
Project: In vivo assessment of inflammation in vascular injury. Abstract presentation ATVB 2011.

  • 1 paper published in Molecular Imaging and Biology

Neha Jakete, BS, Graduate Student (2009)      


Georgios Mallas, PhD, Senior Electrical Engineer, Draeger Medical (2009-2012)
Research: Fluorescence reconstruction in hollow geometries.

  • Previous pre-doctoral student, Department of Electrical Engineering, Northeastern University (Co-mentor with Dr. Vasilis Ntziachristos) 
  • 1 paper published in Physics, Medicine, and Biology, the Journal of the American College of Cardiologythe Journal of Visualized Experiments, and European Heart Journal: Cardiovascular Imaging
  • 2nd place award, Optical Society of America BIOMED conference (2012) 

Crystal Ripplinger, PhD, Assistant Professor of Medicine, University of California, Davis (2009-2010)      

  • NIH T32 fellowship recipient. Oral Abstract Presentation, ATVB Scientific Sessions, San Francisco 2010
  • 1 manuscript published in Arteriosclerosis Thrombosis & Vascular Biology

Amir Rosenthal, PhD, Professor, Technion Israel Institute of Technology (2009-2010)
Research: Intravascular NIRF and optoacoustic imaging (Co-mentor with Dr. Vasilis Ntziachristos).  

  • Fellowship Awardee: Marie Curie Fellowship 2009-2010  
  • 1 paper published in Optics ExpressJournal of Visualized Experiments, and theJournal of the American College of Cardiology, and European Heart Journal: Cardiovascular Imaging

Marcella Calfon, MD, PhD, Assistant Professor of Medicine, UCLA (2009-2012)    

  • Invited presentation, 16th International Congress of Cardiology (2011)
  • Winner, the inaugural Herman K. “Chip” Gold, MGH Young Investigator Award
  • 1 paper published in the Journal of Biomedical Optics, theJournal of the American College of Cardiology, the Journal of Visualized Experiments, and Science Translational Medicine, and European Heart Journal: Cardiovascular Imaging

Jin Won Kim, MD, PhD, Associate Professor of Medicine, Guro University, Seoul, Korea (2009-2011)

  • Oral Abstract Presentation, AHA 2010
  • Oral abstract presentation, ATVB 2011
  • Poster Presentation, AHA 2011 – Top 10% Abstract Best of AHA Specialty Conference:  ATVB
  • 1 manuscript published in Nature Medicine, 1 in Current Cardiovascular Imaging Reports, 1 in Arteriosclerosis Thrombosis & Vascular Biology, and 1 in PLoS One
  • 1 manuscript in preparation

William Hucker, MD, PhD, Internal Medicine Resident (2010-2012)  


Tetsuya Hara, MD PhD, Assistant Professor, Kobe University, Japan (2010-2014)
Project:  Molecular Imaging of Atherosclerosis and Thrombosis

  • Society of Nuclear Medicine Wagner-Torizuka Fellowship Award (2010-2012)
  • Oral abstract Presentations: Top 5 abstracts and Young Investigator Award - 3rd Prize Winner, Basic Science, Society of Nuclear Medicine Annual Meeting (2011); Oral Abstract Presentation, World Molecular Imaging Congress (2011), and First Author Travel Stipend Award Winner. 
  • Recipient, AHA Postdoctoral Fellowship Award (2013-2015) 
  • 1 manuscript published in Nanomedicine, 1 paper in theJournal of American College of Cardiology: Cardiovascular Imaging, Circulation, International Journal of Cardiovascular ImagingEuropean Heart JournalEuropean Heart Journal: Cardiovascular Imaging, and Circulation: Cardiovascular Imaging

Brian Thompson, PhD, Research Technician (2010-2011)


Yair Mega, MSc, Graduate Student (2011-2012)    


Thomas Jetzfellner, PhD, Graduate Student (2011-2012)


Amr El Maghraby, MD, Internal Medicine Resident, Lutheran Medical Center, Brooklyn, New York (2011-2013)
Research: Photodynamic therapy of macrophage-rich atherosclerosis. One manuscript in preparation.


Ashley Stein, BS, Medical Student, Harvard Medical School – HST program (2011-2015)
Research: The role of inflammation in experimental plaque rupture.

  • AHA Pre-doctoral Fellowship Award (2012-2013)
  • Winner, the Judah Folkman Translational Research Prize, Harvard Medical School Student Research Day
  • Recipient, Two abstract presentations, ATVB (2013)
  • 1 abstract presentation, WMIC (2013)
  • Honors Thesis at HMS – graduated cum laude
  • 1 manuscript published in TheranosticsCirculation: Cardiovascular Imaging, andEuropean Heart Journal: Cardiovascular Imaging

Henry Jorge Zelada Castro, MD, Post-Doctoral Fellow (2012-2013)


Johan Verjans, MD, PhD, Cardiology Fellow, Utrecht, Netherlands (2012-2013)
Research: Intracoronary molecular imaging.

  • Recipient, Netherlands Organisation for Scientific Research RUBICON 1 year postdoctoral fellowship award
  • Travel Grant ESC (2015)   
  • Manuscripts published in: Journal of Cardiovascular Translational Research (1), Heart (1), International Journal of Cardiovascular Imaging (1), and JACC: Cardiovascular Imaging (1). One manuscript in preparation

Victor Guanming Qi, MD, PhD, Post-doctoral Fellow (2015-2017)
Research: Nanotherapy for vascular disease.

  • 1 manuscript in preparation

Harkamal Jhajj, BD, Research Technician (2015-2017)    


Lang Wang, MD, PhD, Assistant Professor, Department of Cardiology, Wuhan University (2016-2017)
Research: Intravascular imaging of stent-plaque interactions.

  • Oral presentation, ATVB (2017)
  • Two papers under preparation

Makoto Orii, MD, PhD, Post-doctoral Fellow; Assistant Professor Wakayama Medical University (2016-2018)
Research: Molecular imaging of athero-thrombosis.


Contact

Massachusetts General Hospital
Simches Research Building
185 Cambridge Street, 3206
Boston, MA 02114

Clinical Office (patient inquiries): 617-724-8052
Research Office: 617-724-9353
Fax: 617-860-3180

fjaffer@mgh.harvard.edu

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