The Jaffer Lab

Jaffer Lab: Farouc Jaffer, MD, PhD

The Jaffer Lab at Massachusetts General Hospital is developing new approaches to image high-risk plaques (narrowings, blockages) that cause myocardial infarction (heart attacks), which could ultimately help prevent heart attacks from occurring.

Overview

The laboratory of Farouc Jaffer, MD, PhD, in the Cardiovascular Research Center at Massachusetts General Hospital is developing bench-to-bedside approaches to image and understand in vivo inflammation and thrombogenesis in vascular disease, including atherosclerosis, venous thrombosis, and arteriovenous fistula. 

Through close collaborations with molecular imaging chemistry experts, we have developed an array of molecular imaging agents to report on macrophages, fibrin, cathepsin K, VCAM-1, thrombin, and activated factor XIII. Using intravital microscopy, FMT, MRI or PET-CT, we have imaged and quantified these molecular targets in murine models of vascular disease, which have led to new insights into how atheroma, thrombi, and AVF evolve and resolve.

Our major translational efforts focus on developing intravascular near-infrared fluorescence molecular imaging catheter technology to image inflammation in human coronary arteries and coronary stents, using large animal models. In conjunction with world-leading engineering groups, we have developed intravascular NIRF-OCT and NIRF-IVUS catheters and systems. The ability to image inflammation at high-resolution could provide new approaches to identify high-risk plaques and high-risk stents.

Our clinical research efforts focus on improving percutaneous coronary intervention success for chronic total occlusions, radial artery catheterization, and improving the treatment of microvascular coronary disease and microvascular angina.

Group Members

Principal Investigator

Farouc Jaffer MD, PhD
Director, Coronary Intervention, Massachusetts General Hospital
Director, Mass General Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI) program
Associate Physician, Mass General Cardiology, Department of Medicine


Post-Doctoral Fellows

Mazen Albaghdadi, MD, MSc, Post-Doctoral Fellow (2017-present)

Research: Molecular imaging of inflammation in cardiovascular disease and medical device development.

 

 

  • Recipient NIH T32 Postdoctoral fellowship (2018)
  • Recipient AHA (2019)

Wenzhu Li, MD, Post-doctoral Fellow (2016-present) 
Research: Molecular imaging of venous thrombosis resolution and mechanisms of fibrinolysis.

  • National Nature Science Foundation of China for Young Scholar
  • Chinese Scholarship Council Fellowship Recipient

Stephan Kellnberger, PhD

Stephan Kellnberger, PhD, Post-doctoral Fellow (2014-present)
Research: Molecular thermo-acoustic imaging and intravascular NIRF-IVUS imaging (Co-advisor Vasilis Ntziachristos, PhD).

 

 

 

  • AHA Fellowship Recipient (2017)
  • Feodor Lynen Postdoctoral Research Fellowship Recipient (2014-2016)
  • Papers published in Physical Review Letters, Nature - Scientific Reports, Optics Letters, Applied Physics Letters, and Physics in Medicine and Biology

Eric Osborn

Eric Osborn, MD, PhD,
Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2013-present)
Research: Molecular imaging of atherosclerosis and stent injury.

 

 

  • Recipient NIH T32 Postdoctoral fellowship (2013)
  • Recipient Harvard Catalyst KL2 Award (2013-2015)
  • NIH Loan Repayment Recipient (2014-2016)
  • Papers published in the Journal of the American College of Cardiology:  Cardiovascular Imaging (3), European Heart Journal: Cardiovascular Imaging, Current Atherosclerosis Reports, and the International Journal of Cardiovascular Imaging
  • Two manuscripts in preparation

Jie Cui, MD, Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2014-present)
Research: Imaging of inflammation and thrombosis in arteriovenous fistula.

  • Recipient George B. Rathmann Research Fellowship, American Society of Nephrology (2013-2015)
  • Abstract presentation, ATVB 2013, WMIC 2013, ASN 2013, ASN 2014
  • 1 manuscript published in Arteriosclerosis, Thrombosis, and Vascular Biology

Lab Manager

Adam Mauskapf, BS
Lab Manager (2008-Present)

Adam Mauskapf has been the lab manager for the Jaffer Lab since 2012, and has been with the lab since 2008. He graduated from Bucknell University in 2007. He helps to run the large and small animal research labs and is the research surgeon for the large animal lab. Adam helps to manage the lab, set up surgery schedules, and do many other technical tasks. He has experience in catheterization techniques, micro- and macro-surgery, animal care, anesthesia monitoring, and other aspects of animal research.


Research Technician

Madeleine Grau, BS, Research Technician (2017-Present)


Clinical Research Coordinator

Patricia Giunta, BA
Clinical Research Coordinator (2017-Present)

 


Alumni

Purvish Patel, BS, Graduate Student (2006-2008)

Subsequent Positions:


Kiyuk Chang, MD, PhD, Post-doctoral Fellow (2007-2009)

Subsequent Positions: Associate Professor of Medicine, Catholic University, Seoul, Korea


Ion Botnaru, MD, Post-doctoral Fellow (2008-2010)  

Subsequent Positions: Cardiologist, Olympia, Washington 


Amit Saxena, PhD, Post-doctoral Fellow (2008-2010)  

Subsequent Positions: Albert Einstein University 


Neha Jakete, BS, Graduate Student (2009)

Subsequent Positions:      


Georgios Mallas, PhD, Graduate Student (2009-2012)

Subsequent Positions: Senior Electrical Engineer, Draeger Medical


Crystal Ripplinger, PhD, Post-doctoral Fellow (2009-2010)      

Subsequent Positions: Assistant Professor of Medicine, University of California, Davis


Amir Rosenthal, PhD, Post-doctoral Fellow (2009-2010)

Subsequent Positions: Professor, Technion Israel Institute of Technology 


Marcella Calfon, MD, PhD, Post-doctoral Fellow (2009-2012)    

Subsequent Positions: Assistant Professor of Medicine, UCLA


Jin Won Kim, MD, PhD, Post-doctoral Fellow (2009-2011)

Subsequent Positions: Associate Professor of Medicine, Guro University, Seoul, Korea 


William Hucker, MD, PhD, Post-doctoral Fellow (2010-2012)  

Subsequent Positions: 


Tetsuya Hara, MD PhD, Post-doctoral Fellow (2010-2014)

Subsequent Positions: Assistant Professor, Kobe University, Japan 


Brian Thompson, PhD, Research Technician (2010-2011)

Subsequent Positions:


Yair Mega, MSc, Graduate Student (2011-2012) 

Subsequent Positions:


Thomas Jetzfellner, PhD, Graduate Student (2011-2012)

Subsequent Positions:


Amr El Maghraby, MD, Pre-residency Fellow (2011-2013)

Subsequent Positions: Internal Medicine Resident, Lutheran Medical Center, Brooklyn, New York 


Ashley Stein, BS, Medical Student, Harvard Medical School – HST program (2011-2015)

Subsequent Positions:


Henry Jorge Zelada Castro, MD, Post-Doctoral Fellow (2012-2013)

Subsequent Positions:


Johan Verjans, MD, PhD, Post-doctoral Fellow (2012-2013)

Subsequent Positions: Cardiology Fellow, Utrecht, Netherlands


Victor Guanming Qi, MD, PhD, Post-doctoral Fellow (2015-2017)

Subsequent Positions:


Harkamal Jhajj, BD, Research Technician (2015-2017)

Subsequent Positions:  PhD Student, University of Michigan    


Lang Wang, MD, PhD, Post-doctoral Fellow (2016-2017)

Subsequent Positions: Assistant Professor, Department of Cardiology, Wuhan University


Makoto Orii, MD, PhD, Post-doctoral Fellow (2016-2018)

Subsequent Positions: Assistant Professor, Wakayama Medical University 


Mohammed Chowdhury, MB, ChB,
Post-doctoral Fellow (2017-2018) 

 

 

 

Subsequent Positions: 


Chase Kessinger, PhD, Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2009-2018)

Subsequent Positions: Instructor of Cardiovascular Medicine, Imaging Core Director, Masonic Medical Research Institute


Daqing Li, MD, Post-doctoral Fellow (2017-2018)

Subsequent Positions:


Xiaoxin Zheng, MD, PhD, Post-doctoral Fellow (2017-2019)

Subsequent Positions:


Contact

Massachusetts General Hospital
Simches Research Building
185 Cambridge Street, 3206
Boston, MA 02114

Clinical Office (patient inquiries): 617-724-8052
Research Office: 617-724-9353
Fax: 617-860-3180

fjaffer@mgh.harvard.edu

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