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Research at Mass General
The laboratory of Farouc Jaffer, MD, PhD, in the Cardiovascular Research Center at Massachusetts General Hospital is developing bench-to-bedside approaches to image and understand in vivo inflammation and thrombogenesis in vascular disease, including atherosclerosis, venous thrombosis, and arteriovenous fistula.
Through close collaborations with molecular imaging chemistry experts, we have developed an array of molecular imaging agents to report on macrophages, fibrin, cathepsin K, VCAM-1, thrombin, and activated factor XIII. Using intravital microscopy, FMT, MRI or PET-CT, we have imaged and quantified these molecular targets in murine models of vascular disease, which have led to new insights into how atheroma, thrombi, and AVF evolve and resolve.
Our major translational efforts focus on developing intravascular near-infrared fluorescence molecular imaging catheter technology to image inflammation in human coronary arteries and coronary stents, using large animal models. In conjunction with world-leading engineering groups, we have developed intravascular NIRF-OCT and NIRF-IVUS catheters and systems. The ability to image inflammation at high-resolution could provide new approaches to identify high-risk plaques and high-risk stents.
Our clinical research efforts focus on improving percutaneous coronary intervention success for chronic total occlusions, radial artery catheterization, and improving the treatment of microvascular coronary disease and microvascular angina.
Farouc Jaffer MD, PhD Director, Coronary Intervention, Massachusetts General Hospital Director, Mass General Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI) program Associate Physician, Mass General Cardiology, Department of Medicine
Mazen Albaghdadi, MD, MSc, Post-Doctoral Fellow (2017-present)
Research: Molecular imaging of inflammation in cardiovascular disease and medical device development.
Wenzhu Li, MD, Post-doctoral Fellow (2016-present) Research: Molecular imaging of venous thrombosis resolution and mechanisms of fibrinolysis.
Stephan Kellnberger, PhD, Post-doctoral Fellow (2014-present)Research: Molecular thermo-acoustic imaging and intravascular NIRF-IVUS imaging (Co-advisor Vasilis Ntziachristos, PhD).
Eric Osborn, MD, PhD,Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2013-present)Research: Molecular imaging of atherosclerosis and stent injury.
Jie Cui, MD, Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2014-present) Research: Imaging of inflammation and thrombosis in arteriovenous fistula.
Adam Mauskapf, BSLab Manager (2008-Present)
Adam Mauskapf has been the lab manager for the Jaffer Lab since 2012, and has been with the lab since 2008. He graduated from Bucknell University in 2007. He helps to run the large and small animal research labs and is the research surgeon for the large animal lab. Adam helps to manage the lab, set up surgery schedules, and do many other technical tasks. He has experience in catheterization techniques, micro- and macro-surgery, animal care, anesthesia monitoring, and other aspects of animal research.
Madeleine Grau, BS, Research Technician (2017-Present)
Patricia Giunta, BAClinical Research Coordinator (2017-Present)
Purvish Patel, BS, Graduate Student (2006-2008)
Kiyuk Chang, MD, PhD, Post-doctoral Fellow (2007-2009)
Subsequent Positions: Associate Professor of Medicine, Catholic University, Seoul, Korea
Ion Botnaru, MD, Post-doctoral Fellow (2008-2010)
Subsequent Positions: Cardiologist, Olympia, Washington
Amit Saxena, PhD, Post-doctoral Fellow (2008-2010)
Subsequent Positions: Albert Einstein University
Neha Jakete, BS, Graduate Student (2009)
Georgios Mallas, PhD, Graduate Student (2009-2012)
Subsequent Positions: Senior Electrical Engineer, Draeger Medical
Crystal Ripplinger, PhD, Post-doctoral Fellow (2009-2010)
Subsequent Positions: Assistant Professor of Medicine, University of California, Davis
Amir Rosenthal, PhD, Post-doctoral Fellow (2009-2010)
Subsequent Positions: Professor, Technion Israel Institute of Technology
Marcella Calfon, MD, PhD, Post-doctoral Fellow (2009-2012)
Subsequent Positions: Assistant Professor of Medicine, UCLA
Jin Won Kim, MD, PhD, Post-doctoral Fellow (2009-2011)
Subsequent Positions: Associate Professor of Medicine, Guro University, Seoul, Korea
William Hucker, MD, PhD, Post-doctoral Fellow (2010-2012)
Tetsuya Hara, MD PhD, Post-doctoral Fellow (2010-2014)
Subsequent Positions: Assistant Professor, Kobe University, Japan
Brian Thompson, PhD, Research Technician (2010-2011)
Yair Mega, MSc, Graduate Student (2011-2012)
Thomas Jetzfellner, PhD, Graduate Student (2011-2012)
Amr El Maghraby, MD, Pre-residency Fellow (2011-2013)
Subsequent Positions: Internal Medicine Resident, Lutheran Medical Center, Brooklyn, New York
Ashley Stein, BS, Medical Student, Harvard Medical School – HST program (2011-2015)
Henry Jorge Zelada Castro, MD, Post-Doctoral Fellow (2012-2013)
Johan Verjans, MD, PhD, Post-doctoral Fellow (2012-2013)
Subsequent Positions: Cardiology Fellow, Utrecht, Netherlands
Victor Guanming Qi, MD, PhD, Post-doctoral Fellow (2015-2017)
Harkamal Jhajj, BD, Research Technician (2015-2017)
Subsequent Positions: PhD Student, University of Michigan
Lang Wang, MD, PhD, Post-doctoral Fellow (2016-2017)
Subsequent Positions: Assistant Professor, Department of Cardiology, Wuhan University
Makoto Orii, MD, PhD, Post-doctoral Fellow (2016-2018)
Subsequent Positions: Assistant Professor, Wakayama Medical University
Mohammed Chowdhury, MB, ChB, Post-doctoral Fellow (2017-2018)
Chase Kessinger, PhD, Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2009-2018)
Subsequent Positions: Instructor of Cardiovascular Medicine, Imaging Core Director, Masonic Medical Research Institute
Daqing Li, MD, Post-doctoral Fellow (2017-2018)
Xiaoxin Zheng, MD, PhD, Post-doctoral Fellow (2017-2019)
Massachusetts General Hospital Simches Research Building 185 Cambridge Street, 3206 Boston, MA 02114
Clinical Office (patient inquiries): 617-724-8052 Research Office: 617-724-9353 Fax: 617-860-3180
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