PET-CT

MGH Gordon PET Core

The MGH Gordon PET (positron emission tomography) Core Facility provides a full range of technical and professional services for the design and execution of programs using PET.

Overview

The MGH Gordon PET Core is cGMP/FDA registered PET drug manufacturer. It provides investigators with required personnel, equipment and services to design and conduct research studies using positron emission tomography.

Contact Information

For questions related to human and large animal imaging, please contact:
Steven Weise
Sr. Research Technologist, PET Imaging
Email: weise@pet.mgh.harvard.edu
Phone: 617-726-5299


For questions related to small animal imaging, please contact:
Julia Scotton, B.S., CNMT, RT(N)(CT)
Senior Research Technologist and Safety Manager
Email: jscotton@partners.org
Phone: 617-643-1967


For questions related to drug production, please contact:

Daniel Yokell, Pharm.D.
Manager, PET Production Chemistry
Phone: (617) 643-7541
Fax: (617) 726-5123
Email: dyokell@partners.org


For questions related to study budgets, invoices and payments, please contact:
Ramzi El Fakhri
Business Manager
Phone: 617-724-7212
Email: relfakhri@mgh.harvard.edu


For other inquiries, please contact:
Georges El Fakhri, Ph.D.
Director, MGH Gordon PET Core
Phone: (617) 726-9640
Fax: (617) 726-6165
Email: elfakhri@pet.mgh.harvard.edu

Services

Main services include:

  • Synthesis of radiotracers and radiopharmaceuticals
  • PET and SPECT animal and human imaging
  • Experimental design and pharmacokinetic modeling
  • Validation and regulatory submission of compound for human use

Radiopharmaceuticals Available for Human and Animal Use

The Core has synthesized over 20 compounds for clinical evaluation and routine use for neurology, cardiology and oncology. In addition, it has pioneered the use of 18F Tau imaging agents for neurodegenerative diseases such as Alzheimer’s disease and traumatic brain injuries.

  • F-18
  • FDG* (tumour metabolism/hypometabolism)
  • Florbetaben** (amyloid imaging)
  • Flutemetamol** (amyloid imaging)
  • Florbetapir** (amyloid imaging)
  • Fluciclovine** (tumor metabolism/prostate cancer imaging)
  • Sodium Fluoride** (bone imaging)
  • FES (estrogen receptor)†
  • Flortaucipir [T807] (tau protein)†
  • FPEB (mGlur5)‡
  • BFPET (myocardial perfusion) †
  • GE180 (TSPO/PBR)†
  • FLT (cellular proliferation)†
  • THK 5351/GE-216 (tau protein)†
  • FMISO (hypoxia)†
  • MK-6240 (tau protein) †
  • GE179 (NMDA receptor)‡
  • C-11
  • PiB (amlyoid)†
  • Altropane (Dopamine transport)‡
  • Raclopride (D2/D3 receptor imaging) †
  • Methionine (amino acid uptake)†
  • Acetate (fatty acid synthase) ‡
  • CO (gas for labeling red blood cells in vivo) ‡
  • Rolipram (PDE-4 receptor imaging) ‡
  • P943 (5-HT1B) ‡
  • PBR-28 (TSPO/PBR)† (S,S)-[11C]Methylreboxetine (MeNR/MRB)‡ – targets norepinephrine transporter
  • N-13
  • Ammonia*
  • N2 in Saline (lung perfusion imaging) ‡
  • Ga-68
  • DOTATATE** (neuroendocrine tumor imaging)
  • O-15
  • C15O2 (blood flow imaging) ‡

*FDA approved, MGH PET Center holds FDA marketing authorization

**FDA approved, available through local commercial nuclear pharmacies

†Active IND held by MGH Gordon PET Core

‡Available under Radioactive Drug Research Committee (RDRC) oversight

The MGH Gordon PET Core can validate a radiopharmaceutical for clinical research use.

Please send inquiries to:

Daniel Yokell
Associate Director, Radiopharmacy and Regulatory Affairs, MGH
Email: dyokell@mgh.harvard.edu or Phone: 617-643-7541.

Equipment

  • GE Discovery PET/CT
  • Automated Radiochemical Synthesis systems
  • E.cam (Siemens) SPECT Systems and Planar Gamma Cameras
  • Exact HR+ Large Bore PET Scanner
  • NeuroPET/CT dedicated high sensitivity brain scanner
  • PC4096 Large Bore PET Scanner
  • Siemens PET/CT Scanner
  • Siemens Symbia SPECT/CT
  • VISTA small animal micro PET/CT
  • Tri-modality MicroPET-SPECT-CT

Fee Schedule

ServicesInternal User Fee for Non-Profit and Federal Sponsored Research (Direct Cost*)Internal User Fee for Industry Sponsored Research (Direct Cost*)External User Fee for NON- PROFIT and FEDERAL Sponsored Research (Inclusive of Institutional Indirect Cost*)External User Fee for Industry Sponsored Research (Inclusive of Institutional Indirect Cost*)
13N Ammonia $3,895.00 $5,842.50 $5,608.80 Please contact PET Core for rate
13N2 PET GMP Production + Imaging $2,772.00 $4,158.00 $3,991.68 Please contact PET Core for rate
13N2 PET Production + Imaging $1,372.00 $2,058.00 $1,975.68 Please contact PET Core for rate
13NH3 Cardiac Blood Flow $3,691.00 $5,536.50 $5,315.04 Please contact PET Core for rate
18F FDG $2,215.00 $3,322.50 $3,189.60 Please contact PET Core for rate
Other PET GMP Production + Imaging (includes: 11C Compounds and 18F Compounds; excludes: 18F FDG, 13NH3, 13N2 and 13N Ammonia) $3,186.00 $4,779.00 $4,587.84 Please contact PET Core for rate
Other PET Production + Imaging (includes: 11C Compounds and 18F Compounds; excludes: 18F FDG, 13NH3, 13N2 and 13N Ammonia) $2,363.00 $3,544.50 $3,402.72 Please contact PET Core for rate
PET Imaging Only (up to two hours) $ $2,104.00 $3,156.00 $3,029.76 Please contact PET Core for rate
Additional Imaging Time (per hour) $446.00 $669.00 $642.24 Please contact PET Core for rate
Phantom Imaging $1,465.00 $2,197.50 $2,109.60 Please contact PET Core for rate
F18 Compound Dose (No Imaging) $2,103.00 $3,154.50 $3,028.32 Please contact PET Core for rate
Cyclotron Beam Time for Isotope Production (per hour) $907.00 $1,360.50 $1,306.08 Please contact PET Core for rate
Micro PET Imaging Only (up to 2 hours) $420.00 $630.00 $604.80 Please contact PET core for rate
Micro PET Additional Imaging Hour $108.00 $162.00 $155.52 Please contact PET core for rate
Blood Processing $1,057.00 $1,585.50 $1,522.08 Please contact PET core for rate
Consent Charge $100.00 $150.00 $144.00 Please contact PET core for rate
CT $1,007.00 $1,510.50 $1,450.08 Please contact PET core for rate
IRB Renewal $3,379.00 $5,068.50 $4,865.76 Please contact PET core for rate
Kinetic Modeling $950.00 $1,425.00 $1,368.00 Please contact PET core for rate
Radionuclidic Purity Testing $364.00 $546.00 $524.16 Please contact PET core for rate
Regulatory Submission $10,115.00 $15,172.50 $14,565.60 Please contact PET core for rate
SALSA Generator Validation $2,742.00 $4,113.00 $3,948.48 Please contact PET core for rate
SPECT  $1,957.00 $2,935.50 $2,818.08 Please contact PET core for rate
SPECT-CT $2,363.00 $3,544.50 $3,402.72 Please contact PET core for rate
Start-up Fee $7,090.00 $10,635.00 $10,209.60 Please contact PET core for rate
Technician Training / Site Qualification (per hour) $293.00 $439.50 $421.92 Please contact PET core for rate
Validation of Radiotracer for Animal Use $14,677.00 $22,015.50 $21,134.88 Please contact PET core for rate
Validation of Radiotracer for Human and NHP Use $26,220.00 $39,330.00 $37,756.80

Please contact PET core for rate


The Core commits its best efforts to successfully complete scheduled studies. However, given the very nature of many PET studies that rely on manufacturing of the radiopharmaceutical and in vivo imaging, the Core cannot cover costs associated with uncompleted studies due to equipment failure or circumstances outside of our control.

A fee, up to the cost of the cancelled service, can be charged in relation with a study in the event of a last minute cancellation or a no-show.

* A Partners investigator using a Partners fund is considered an internal user and will be subject to the institutional overhead rate applied by Partners Research Management. The external user fee comprises a direct fee negotiated with the PET Core plus an overhead component. The overhead rate set by Partners is 44% for external academic users and 59% for external industry users.

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