Echocardiography Core Laboratory

The Echocardiography Core Lab at Massachusetts General Hospital provides expert echocardiography readings for public and privately funded clinical trials.


The Massachusetts General Hospital Echocardiography Core Lab (Echo Core Lab) has extensive experience in measuring echocardiograms from clinical trials involving patients with right ventricular (RV) dysfunction, left ventricular (LV) dysfunction, mitral regurgitation, native aortic valve stenosis and prosthetic valve function.

The lab has an extensive history of serving publicly and privately funded clinical trials.

The lab has acted as the core lab for a number of publicly funded trials, including:

  • Cardiothoracic Surgical Network Trials (CTSN)
  • CTSN and Cardiovascular Cell Therapy Research Network (CCTRN) mesenchymal progenitor stem cell therapy in patients with left ventricle assist devices (LVAD)
  • CTSN LVAD II trials
  • ISCHEMIA (International Study of Comparative Health Effectiveness and Invasive Approaches) 
  • National Heart, Lung and Blood Institute (NHLBI) SHOCK Trial
  • National Institutes of Health (NIH) Specialized Center on Research (SCOR) trial on assessment of myocardial infarction
  • NHLBI Multidisciplinary Study of Arrhthmogenic RV Dysplasia
  • VITAL Trial (Study of Vitamin D and Omega 3 on Left Ventricle Functions of the Heart)

The lab has served as a core lab for many industry-funded clinical trials, including:

  • The 8G9928 in stable heart failure (Biogen)
  • Backbeat Moderato System
  • The CADET Trial (Amersham)
  • The CAPTIN Trial (Bristol Myers Squibb)
  • The EVOLVE Trial (Mitsubishi Pharma)
  • The Multisite Pacing in End Stage Heart Failure Trial (Pacesetter, Inc.)
  • The REVIVE Trial (Edwards)


Group Members

  • Michael H. Picard, MD (Co-Director)
  • Judy Hung, MD (Co-Director)
  • Xin Zeng, MD (Senior Echocardiologist)
  • Yong Hyun Park, MD (Echocardiologist)
  • Danita Sanborn, MD (Echocardiologist)
  • Marielle Crosbie-Scherrer, MD (Echocardiologist)

Facilities & Equipment

The Echocardiography Core Lab at Massachusetts General Hospital has over 250 square feet of workspace dedicated to analyzing echocardiograms. Optical disk readers for 3.5 inch and 5.25 inch magneto-optical disks (MOD), CD readers and DVD readers are networked to our three Picture, Archiving and Communication Systems (PACS) that are used for the measurements.

Digital images can be read in Digital Imaging and Communications in Medicine (DICOM) or proprietary format. Although we prefer echocardiograms submitted on digital media, on select cases, we can accept videotape.

The images and “screen shots” of the measurements are archived in a series of DVD jukeboxes with over 25 TB of storage space. The jukeboxes are located in a secure server room with limited access. The images can be kept throughout the duration of the project and for up to seven years thereafter. The Echo Core Lab also is contracted with Iron Mountain, a commercial storage company, for additional storage if necessary.

Optical disk readers for 3.5 inch and 5.25 inch MOD, CD readers and DVD readers are networked to our three PACS that are used for the measurements so that digital images can be read, whether in DICOM or proprietary format. For images recorded on videotape, selected echo images are digitized and measured on a Kodak ImageVue workstation and/or MEDIS Echo CMS workstation. Digital images recorded on CD, MOD or DVD are directly measured.

Data Transmission:

The Echo Core Lab is part of the Partners HealthCare system, which utilizes Send Secure, software that sends encrypted uploads and email submission. Partners HealthCare maintains a firewall for secure digital transfers and makes a Secure File Transfer & Collaboration solution available for exchanging large files with collaborators both inside and outside of Partners via a web browser. This service is a secure web-based application with anti-virus detection built in. All files added to the system are encrypted during transfer and are scanned for viruses. Recipients receive an email with a link to download the file


The Mass General Echo Core Lab provides the following services: 

  • Certifying clinical sites for echocardiographic studies related to a clinical trial
  • Providing feedback and quality assessment of echocardiograms for clinical sites
  • Performing analyses of echocardiograms
  • Developing echocardiographic protocols specific to clinical trials
  • Maintaining records of the number echocardiograms performed
  • Securing and archiving echocardiograms

Fee Schedule

The Massachusetts General Hospital Echo Core Lab can tailor costs specific to the needs of the trial. Please contact us for more information.


Contact Us

Echocardiology Core Laboratory

Yawkey Building/Suite 5408

55 Fruit St. Boston, MA 02155
  • Near Public Transit
  • Accessible

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