Browse by Medical Category
Research at Mass General
The Massachusetts General Hospital Pancreatic Islet Isolation Laboratory is a specialized service facility providing services for research and clinical care use, and the only lab in New England that practices the FDA-approved current Good Manufacture Procedure (cGMP) standards. We are one of few active laboratories in the United States that collaborates within the National Institutes of Health-sponsored Consortium of Islet Transplantation (CIT) and its affiliates to advance clinical islet transplantation from an experimental to a standard care procedure.
Since its inception in 2008, the Pancreatic Islet Isolation Laboratory has processed more than 160 human pancreata in a state-of-the-art cGMP facility for use in clinical islet transplantation, as well as research. We continue to optimize the process of islet isolation to ensure the best patient outcomes. Our first type I diabetic patient is more than five years post allogenic pancreatic islet transplantation, with a functioning graft and is insulin-independent.
In 2011, we expanded our program to provide autologous human islet isolation to patients undergoing total pancreatectomy. This approach is an innovative and very successful therapeutic option for cases of chronic pancreatitis that have not responded to conventional intervention. To date, approximately 30 patients from Mass General, Brigham and Women’s Hospital and the Dartmouth-Hitchcock Medical Center of Dartmouth Medical School have benefited from this revolutionary technology.
We have conducted a variety of experimental studies on pancreatic islet transplantation in primate, porcine and rodent models. We collaborate with researchers nationally to provide high quality nonhuman primate (NHP) islets for research. Our extensive experience in areas such as tolerance induction, encapsulation of islets, large/small animal surgery, islet isolation and animal care allow us to be an ideal contractor or resource center for related studies.
James F. Markmann MD, PhD
Principal InvestigatorMassachusetts General Hospital Pancreatic Islet Isolation Laboratory, Center for Transplantation Sciences (CTS)Chief of Division of Transplantation SurgeryView publicationsEmail
Ji Lei MD, MBADirector, Mass General Pancreatic Islet Isolation Laboratory, CTSEmailJames Kim, PhDPrincipal Investigator, CTS
Christian Schuetz, MD, PhDScientist, CTS
James H. Avruch, MDPost-Doctoral Research FellowScientist, CTS
Tao Chen, MDScientist, CTS
Anthony Sabadini, CRAAdministrative Manager for ResearchMass General Pancreatic Islet Isolation Laboratory, CTSEmail
The Massachusetts General Hospital Pancreatic Islet Isolation Laboratory has available positions for a research technologist and technician positions. Contact Ji Lei, MD, MBA for more information.
The Massachusetts General Hospital Pancreatic Islet Isolation Laboratory is an FDA-approved current Good Manufacturing Procedures (cGMP) facility comprising leading technology and equipment to meet research needs.
The Massachusetts General Hospital Pancreatic Islet Isolation Laboratory provides the following services to Mass General, Harvard-affiliated hospitals and research facilities, and other clinical and research institutions throughout the United States:
The Massachusetts General Hospital Pancreatic Islet Isolation Laboratory is available to assist researchers in islet isolation. Please contact Anthony Sabadini for a fee schedule.
Back to Top