Circadian Rhythms and Sleep in Human Disease

My work focuses on understanding genetic differences that determine people’s daily behavioral rhythms and sleep patterns, and how these differences are linked with neurologic, neuropyschiatric and metabolic disease.

We are studying how a genetic change in the receptor for melatonin, the hormone that regulates sleep and wake cycles, can influence blood sugar control in shift workers and late-night eaters.

We have also identified genetic differences that determine we are night owls or larks, and differences that contribute to sleep disorders such as insomnia and daytime sleepiness.

Our results suggest that both circadian rhythm and sleep traits share genes and pathways with psychiatric diseases such as schizophrenia, depression and autism, and metabolic diseases such as obesity and diabetes.

We also know that many neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, disrupt sleep patterns.

Our goal is to identify new therapies for sleep disorders, and to identify where interventions that target sleep or circadian rhythms could be used to prevent or delay human disease.

About the MGH Research Scholars

The MGH Research Scholars Program was established to support early career researchers with innovative yet unproven ideas that have the potential to transform the future of medicine. Funded 100% through philanthropy, this program gives researchers the freedom and flexibility they need to follow the science wherever it leads. Time and time again, history has shown that brilliant scientists who are given free rein to explore new frontiers are the ones who make the greatest, often wholly unexpected, advances.

Learn more about the MGH Research Scholars Program.

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