John Mullen, MD

Sarcoma Surgery Program

Massachusetts General Hospital's Sarcoma Surgery Program provides expert care within a multidisciplinary Cancer Center team and specializes in the diagnosis and treatment of sarcomas.
Request an appointment Refer a patient

Call to request an appointment or refer a patient: 617-726-5507


Specialized Expert Care

The Sarcoma Surgery Program in the Division of Surgical Oncology at Massachusetts General Hospital offers expert care within a multidisciplinary Mass General Cancer Center team. Soft tissue sarcomas are uncommon cancers, and as such, significant expertise is required for their optimal treatment. Sarcomas are cancers that arise from the body's connective tissues, such as muscle, fat and nerves. There are hundreds of different types of sarcoma and each requires a specific treatment approach.

The Connective Tissue Oncology Clinic (CTOC) at the Mass General Cancer Center houses one of the few medical teams in the world devoted to sarcomas. We are a high volume clinic, granting us a level of experience with these tumors that will make a difference in your outcome.

Collaborative Approach to Diagnosis and Treatment

surgical oncology nurses
Mass General's nursing staff is a critical part of your care team and Magnet® recognized. This award is the highest honor an organization can receive for professional nursing practice.

During your first appointment, your multidisciplinary care team, which includes a surgeon, will review your medical history with you and schedule any tests needed to help with diagnosis. The proper diagnosis of a soft-tissue sarcoma can be quite challenging, but an accurate diagnosis is essential to successful treatment. It is critical to have a proper pre-treatment biopsy, which is reviewed by an expert soft tissue pathologist. Our pathologists are dedicated to sarcoma and they use advanced testing to pinpoint the type of sarcoma you have.

Once a diagnosis of sarcoma is confirmed, we utilize a team approach that brings together specialists from many areas, including surgical oncology, medical oncology and radiation oncology. We offer everything you need for diagnosis and treatment in one location.

Mass General Difference

Having your sarcoma surgery at Mass General gives you access to a breadth of excellent surgeons, in all surgical specialties, who are skilled in treating patients with complex medical diagnoses. Plastic surgeons manage large tissue defects; thoracic surgeons remove lung metastases from sarcomas; and orthopedic surgeons operate on sarcomas close to or involving bone.

Mass General is consistently ranked among the best hospitals in the country by U.S. News & World Report. Our ranking is based on our quality of care, patient safety and reputation in more than a dozen different clinical specialties. Our commitment to excellence means that we work to ensure that you receive the best care at all points during your visit.

Appointments and Referrals

You will need a referral from your primary care physician to make an appointment with one of our surgeons. You may request an appointment online or call 617-726-5507. Once your referral is received, a patient coordinator will contact you to schedule your first appointment.

About this Program

Minimally Invasive and Advanced Surgical Techniques

When appropriate, surgical oncologists at Massachusetts General Hospital use minimally invasive surgical techniques, such as laparoscopic abdominal surgery, to confirm the diagnosis and/or to remove certain sarcomas, such as gastrointestinal stromal tumors (GISTs). Minimally invasive surgery offers the advantages of less postoperative pain, a shorter hospital stay and an earlier return to normal activity.

Additionally, we use the latest technology and advanced surgical techniques to save limbs and their function and appearance. By taking a multidisciplinary approach to sarcoma treatment, our surgeons have changed the way they operate on tumors. In the past, sarcomas occurring in the extremities (limbs) were routinely treated with amputation. Currently, limb-sparing surgery is often combined with radiation and chemotherapy, such that only about 5% of these cases require amputation.

As one of the world's leading sarcoma research centers, we helped pioneer many advancements that are used today around the world, including:

  • New ways to combine therapies, including surgery, chemotherapy and radiation, to more successfully treat large, high-risk extremity sarcomas
  • Novel chemotherapy agents that are more effective, more targeted at the molecular level and that have fewer side effects
  • High-quality surgery to remove retroperitoneal (space in the abdominal cavity) and extremity sarcomas with negative margins (cancer is not growing into the edges of the tissue removed), minimizing the chance of local recurrence
  • Highly effective, targeted radiation techniques, including the use of proton beam therapy, intensity-modulated radiation therapy and radiation therapy during surgery, to facilitate limb-sparing and organ-preserving surgical techniques and to minimize the risk of recurrence

Preparing for your Surgery

Your care team will work with you to coordinate all aspects of your surgery. Depending on your case, you may see an anesthesiologist or a surgical specialist such as a plastic surgeon, in addition to your sarcoma surgeon, prior to surgery. You will be asked to come in for a follow-up visit two weeks after your surgery to assess your progress and discuss your treatment program further.

Research and Innovation

As an academic center, Mass General invests in research to understand diseases and develop new approaches to treatment. Our doctors are leaders within their respective fields, and collaborate with colleagues in various departments across the hospital. As a patient, you benefit from shared expertise, leading research and our commitment to quality and excellence.

Learn more about available studies and clinical trials

Our Surgeons

  • Haynes, Alex B., MD


    Accepting New Patients

    Clinical Interests
    • Melanoma
    • Gastrointestinal stromal tumor (GIST)
    • Retroperitoneal sarcoma
    • Soft tissue sarcoma
    • Skin cancer
    • Desmoid
    Board Certifications
    • Surgery, American Board of Surgery
    • Surgical Oncology, American Board of Surgery
    • Boston: Surgical Oncology Associates
  • Mullen, John T., MD


    Accepting New Patients

    Clinical Interests
    • Soft tissue sarcoma
    • Stomach (gastric) cancer
    • Retroperitoneal sarcoma
    • Gastrointestinal stromal tumor (GIST)
    • Carcinoid tumor
    • Desmoid tumor
    • Gastrointestinal cancer
    • Melanoma
    Board Certifications
    • Surgery, American Board of Surgery
    • Boston: Surgical Oncology Associates
    • Waltham: Mass General Waltham
  • Qadan, Motaz, MD, PhD


    Accepting New Patients

    Clinical Interests
    • Pancreatic and hepatobiliary surgery
    • Pancreatobiliary surgery
    • Liver surgery
    • Pancreatic cancer
    • Liver metastases
    • Liver cancer
    • Pancreatic cystic tumors
    • Hepatocellular carcinoma, Cholangiocarcinoma, Liver tumors
    • Surgical oncology
    • Minimally invasive surgery
    Board Certifications
    • Surgery, American Board of Surgery
    • Complex General Surgical Oncology, American Board of Surgery
    • Boston: Surgical Oncology Associates

Conditions & Diseases

  • Cardiac Sarcoma

    Cardiac sarcoma is a type of tumor that occurs in the heart. Cardiac sarcoma is a primary malignant (cancerous) tumor.

  • Chondrosarcoma

    Chondrosarcoma is a type of bone cancer that develops in cartilage cells.

  • Ewing Sarcoma

    Ewing sarcoma is a cancer that occurs primarily in the bone or soft tissue.

  • Osteosarcoma

    Osteosarcoma is a type of bone cancer that develops in the osteoblast cells that form the outer covering of bone.

  • Other Types of Skin Cancer: Kaposi's Sarcoma / Paget's Disease

    Kaposi's sarcoma is a skin cancer that starts in the skin's blood vessels. Kaposi's sarcoma comes in two forms: a slow-growing form, and a more aggressive, faster-spreading form.

  • Rhabdomyosarcoma

    Rhabdomyosarcoma is a cancerous tumor that originates in the soft tissues of the body, including the muscles, tendons, and connective tissues.


Contact Us

Division of Surgical Oncology

Yawkey Building

55 Fruit Street, Yawkey 7 Boston, MA 02114
  • Near Public Transit
  • Accessible
  • Phone: 617-726-5507
  • Fax: 617-724-3895
  • Email Us


  • 8:30 am-5:00 pm
Request an appointment Refer a patient

Call to request an appointment or refer a patient: 617-726-5507

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