Jill Palermo (right) donated a kidney to her cousin, Jeanette Bernard (left)
Jill Palermo (left) donated a kidney to her cousin, Jeanette Bernard (right). Read their story.

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Live Donation

Live donation allows patients to receive a transplant without waiting for an organ from a deceased donor. The Massachusetts General Hospital Transplant Center has one of the most active and experienced living kidney and liver donor programs in the region, as well as the largest, and performed the most deceased and living donor kidney transplants in 2019.

Explore the History of Living Donation

1954

  • First successful kidney transplant between identical twin brothers at Peter Brigham Hospital, now known as Brigham and Women’s Hospital
  • First successful living kidney donation happened in Boston when a living donor gave a kidney to his identical twin

1967

First successful liver transplant

1968

First successful heart transplant in United States

1980

First successful lung transplants

1984

National Organ Transplant Act is passed, prohibiting the selling of organs and establishing the Organ Procurement and Transplantation Network to ensure the fair and equitable allocation of donated organs

1989

First successful living donor liver transplant

1990

First successful living donor lung transplant

1992

Coalition on Donation (later renamed Donate Life America) founded

1995

First living donor kidney removed by laparoscopic surgical method

2003

April designated as annual National Donate Life Month

Living Donor Kidney Program

Donating a kidney to another individual is an act of great kindness. Nearly half of the kidneys transplanted at Mass General are given by living donors—family members, friends, co-workers and donors who are unknown to the recipient.

There are several benefits to receiving an organ through living donation, as well as becoming a living donor.

Benefits for Recipients
  • It is quicker than waiting to receive an organ through the deceased donor waitlist
  • It reduces time spent on dialysis
  • There is immediate impact, as a kidney from a living donor usually functions right away and, on average, lasts longer than a deceased donor kidney
  • There is more comprehensive knowledge of the donor and their lifestyle
  • Along with the donor, you pick the surgery date that works best for your schedule
  • Your choice to receive an organ through a living donor subsequently shortens the time others in need of an organ have to wait on the deceased donor waitlist
Benefits for Donors
  • Many donors have described this process as being a positive emotional experience
  • It results in more time with your loved one(s)
  • If you donate through the National Kidney Registry, your gift goes even farther and can enable multiple transplants
  • Along with the recipient, you pick the surgery date that works best for your schedule
  • Your choice to be a living donor subsequently shortens the time others in need of an organ have to wait on the deceased donor waitlist

Patients who choose to undergo a kidney transplant may have identified a living donor who is willing to donate a kidney. Even in cases where the donor is incompatible with the recipient, our active living donor transplant program can match patients with compatible living donors through the UNOS Paired Kidney Exchange Program or the National Kidney Registry (NKR).

Why Choose Mass General

At Mass General, we are proud to be the largest living donor kidney transplant program in the region, as well as the largest kidney exchange program for those who do not match with their intended recipient. A dedicated team of coordinators and surgeons guide the donors throughout the process and value donor candidates' time. All initial consultations start remotely and candidates will be invited for a physical evaluation at Mass General if the records and results are favorable.

We offer advanced donation and remote donation. In fact, Mass General was the first center in the country to receive a remote kidney donation, when a kidney was donated in San Diego and given to a recipient in Boston.

We offer a robust telemedicine platform to allow for remote follow-up after surgery and strive to discharge patients after surgery as soon as it’s safe and the donor is comfortable—it could be as early as the day after surgery.

The Process to Become a Living Donor Kidney

Individuals who wish to become living donors undergo a three-part evaluation process. Our dedicated donor coordinators guide potential donors through each step, keeping them informed of testing and evaluation results. Typically, the recipient's insurance will cover the cost of the evaluation and surgery.

Phase One: Living Donor Health Questionnaire
  • Donor evaluation begins with the prospective donor submitting a completed living donor health questionnaire to determine their overall health status and candidacy to donate
  • Once a completed living donor health questionnaire is received, the donor will receive a confirmation email with further instructions
Phase Two: Multidisciplinary Team Evaluation (Part 1)
  • The donor candidate will complete lab work (blood and urine, including a 24-hour urine collection) at a local lab. Once the donor team receives the results, and if they do not find any serious abnormalities, the donor candidate can be scheduled for an appointment(s)
  • Candidates come to Mass General for a half-day donor evaluation visit. This visit includes an educational session, a meeting with the donor coordinator, social worker and a nephrologist (a doctor who specializes in kidney care), who reviews the candidate’s medical history and conducts a physical examination
  • The physical examination includes an electrocardiogram (EKG) and chest x-ray
  • Based on the medical history and physical exam, other tests may be necessary and can often be scheduled close to the candidate’s home
Phase Three: Multidisciplinary Team Evaluation (Part 2)
  • The donor candidate returns to Mass General for a computed tomography (CT) scan of the kidneys and blood vessels, as well as any other necessary appointments or tests (depending on scheduling availability)
  • This visit includes meeting with the surgeon to discuss the candidate’s ability to donate, as well as the surgical procedure and hospital experience
  • The donor candidate also meets with the independent donor advocate, who works with the donor candidate to ensure that his or her best interests are represented and that decisions made are to the benefit of the donor

Once all tests are complete, the donor’s candidacy is reviewed at the Mass General Transplant Center’s multidisciplinary kidney transplant selection meeting. If the donor is approved, donation surgery can be scheduled on a date that is convenient for both the donor and recipient, or the donor can begin the process of being entered into the paired exchange.

Kidney Donor Resources

The Mass General Transplant Center actively participates in many donor support and advocacy initiatives. We are a chartered member of WELD (WoMen Encouraging Living Donation), which is a network of living donor advocate. We also partner regularly on education and outreach initiatives, as well as organize regular donor forums. With these forums, we bring together Mass General donors to foster opportunities for education and community building and to ensure continuation of relationships following donation.

Q. What if I am not a compatible donor?

Mass General participates in the National Kidney Registry (NKR), an independent organization that facilitates transplants for patients with incompatible living donors as well as for antibody, blood type, size and age issues. A computer program finds suitable donors from other mismatched pairs in the NKR, and identifies the necessary exchanges needed to allow all corresponding recipients to be transplanted from a suitable donor. Patients may be part of a multi-pair chain that results in several recipients being transplanted across many states.

Mass General can register patients with incompatible living donors in the UNOS Paired Kidney Exchange Program, which works to expedite transplants in patients with blood group antibodies or other incompatibilities to their potential living donors.

Q. What are the financial implications of becoming a donor?

Donor evaluation testing, appointments and the surgery itself are covered by the recipient's insurance—this does not include any preventative screening costs, travel and accommodation expenses or parking costs; however, we can provide resources that may help with these types of extra expenses. The National Living Donor Assistance Center's (NLDAC) mission is to reduce the financial disincentives to living organ donation. They operate a nationwide system that provides reimbursement of travel and subsistence expenses to people being evaluated for and/or undergoing living organ donation.

Donor Shield is a donor protection program run by the NKR. The Donor Shield Program Centers' offerings include reimbursement of lost wage and travel, offered to Mass General living donors who participate in an NKR swap.

Become a living donor kidney

Living Donor Liver Program

Mass General has one of the most experienced living donor liver transplant programs in New England. Through living donation, a person donates a portion of their liver to someone in need of a liver transplant, allowing patients with end-stage liver disease to receive a transplant without a prolonged waiting period. The donor’s healthy liver grows back to full size within a few weeks.

Donating a portion of your liver to another individual is a great act of kindness and can be lifesaving for the recipient. A liver transplant is a complex surgery for both the donor and the recipient. In order to effectively plan for the surgery and ensure the best possible outcomes, the Mass General Brigham liver transplant team evaluates living donors in a three-part process. Potential donors may choose to discontinue their evaluation at any point in the process, for any reason, with complete confidentiality.

Learn more about living liver donation

Video about Organ Donation

Patient Stories

Learn More

The Massachusetts General Hospital Transplant Center offers leading-edge consultative services, treatment and surgical interventions to patients with a broad spectrum of diseases.