liver

Liver Transplant Program

The Massachusetts General Hospital Transplant Center has performed more adult and pediatric liver transplants than any other center in New England, and has maintained some of the best graft and patient survivals in the country.
Request an appointment Refer a patient

Call to request an appointment or referral: 877-716-8440

Overview

A pioneer in organ transplant since 1963, the Mass General Transplant Center draws from state-of-the-art technology and leading-edge medical and surgical interventions to provide individualized, ongoing care for adult and pediatric patients with liver disease. Since 1988, Mass General has performed more than 1,000 liver transplants, making us one of the largest transplant centers in New England. Our Liver Transplant Program provides complete treatment, transplant and management options for patients with acute or chronic liver disease, as well as patients with liver cancer. Learn more about pediatric liver transplantation at MassGeneral Hospital for Children

Advanced Evaluation, Multidisciplinary Care

Our patients receive integrated, comprehensive care, beginning with a careful assessment and discussion to ensure that transplantation is the

Liver Transplant Clinic Locations
Liver Evaluation Clinic Locations

patient’s best treatment option. Candidates work with a transplant coordinator, who participates in the initial evaluation, gathers medical information and previous test results, and manages the patient’s full evaluation, which includes patient education, medical, surgical and psychosocial evaluation, and transplant-specific testing. Learn more about the pre-transplant evaluation

Liver transplant candidates are placed on the national United Network for Organ Sharing (UNOS) waiting list, which manages the distribution of organs nationwide. Read about the waiting list

Collaborations with Liver Center and Cancer Center

Specialists at the Mass General Transplant Center work closely with their colleagues in the Mass General Liver Center and Mass General Cancer Center. This collaboration allows patients

 with liver disease and cancer to receive coordinated care that includes the most advanced diagnostic and treatment options. Many patients with liver cancer are eligible for liver transplantation. Our surgeons have extensive experience in both complex and minimally invasive removal of liver tumors.


Learn more about liver cancer treatment at the Mass General Cancer Center and the diagnosis and treatment of liver disease at the Mass General Liver Center

Living Donor Liver Transplant Program

Mass General has one of the most active and experienced living donor liver transplant programs in New England. Through living donor liver transplantation, a family member or friend donates a portion of his/her liver, allowing patients to receive a transplant without a prolonged waiting period. The donor’s healthy liver grows back to full size within a few weeks.

Those interested in living liver donation can contact our donor coordinator at 877-644-2860 for a confidential conversation to learn more, without any commitment to donation. Learn more about the donor evaluation.

Become a Donor

Donating a portion of your liver to another individual is a great act of kindness and can be life saving for the recipient. A liver transplant is a complex surgery for both the donor and the recipient.

In order to effectively plan for the surgery and ensure the best possible outcomes, the Mass General Liver Transplant Team evaluates living donors in a three-part process. Potential donors may choose to discontinue their evaluation at any point in the process, for any reason, with complete confidentiality. Typically, the Transplant Center and the recipient's insurance will cover the cost of the evaluation and surgery.

Phase One: Questionnaire and Blood Tests

  • Donors must be between the ages of 18 and 55, and have no serious medical problems
  • The donor evaluation begins with the potential donor contacting our transplant center and answering a few questions that allow us to determine the donor’s overall health status
  • Standard blood tests will be done to determine blood type, liver function and overall health status. Blood testing can be performed at Mass General or at another local hospital

Phase Two: Team Evaluation and Surgeon Visit

  • The donor will meet with our hepatologist, living donor nurse coordinator, financial coordinator, social worker, living donor advocate and nutritionist to learn about the donation process and to ask any questions   
  • The evaluation includes a complete medial history and physical examination, and additional testing such as an electrocardiogram (EKG), chest X-ray, a CT scan of the abdomen to evaluate liver anatomy and other blood work or tests as needed
  • Next, the donor will meet with a surgeon from the Mass General Liver Transplant Program to discuss the surgical procedure and hospital stay. The operation is performed using a laparoscopic-assisted technique, and the majority of donors go home five to seven days after surgery

Phase Three: Anesthesia Evaluation and Scheduling Surgery

  • Once all tests are complete, the transplant team will discuss the donor's eligibility at our weekly multidisciplinary liver transplant meeting to determine if the donor is approved for surgery. Once approved, we will schedule the surgery on a date that is convenient for both the donor and recipient
  • The donor will meet with his/her surgeon to sign the surgical consent form and to answer any last-minute questions. The donor will also meet with an anesthesiologist to discuss the anesthesia process and answer any additional questions

If you would like to make an appointment or talk to someone about our donor evaluation process, please call 877-644-2860. Request an appointment online

Our Team

Transplant

  • Markmann, James F., MD, PhD

    617-643-4533

    Accepting New Patients

    Clinical Interests
    •  Pancreas and islet transplant
    • Hepatobiliary surgery
    • Vascular access for hemodialysis
    • Kidney (renal) transplant
    • Minimally Invasive Surgery
    • Liver Transplant
    Board Certifications
    • Surgery
    Locations
    • Boston: Massachusetts General Hospital

  • Elias, Nahel MD, FACS

    617-726-5277

    Accepting New Patients

    Clinical Interests
    • Liver cancer
    • Hepatobiliary surgery
    • Hepatitis C
    • Kidney (renal) transplant
    • Hepatocellular carcinoma, Cholangiocarcinoma, Liver tumors
    • Liver Transplant
    Board Certifications
    • Surgery
    Locations
    • Boston: Massachusetts General Hospital

  • Yeh, Heidi MD

    617-726-6631

    Accepting New Patients

    Board Certifications
    • Surgery
    Locations
    • Boston: Massachusetts General Hospital

  • Kawai, Tatsuo MD, PhD

    617-726-0289

    Accepting New Patients

    Clinical Interests
    • Laparoscopic donor nephrectomy
    • Organ transplantation (kidney, liver and pancreas)
    • Vascular access surgery for renal failure
    Locations
    • Boston: Massachusetts General Hospital

  • Kimura, Shoko MD

    617-643-4533

    Accepting New Patients

    Locations
    • Boston: Massachusetts General Hospital
  • Dageforde, Leigh Anne MD, MPH

    617-726-5277

    Accepting New Patients

    Clinical Interests
    • Transplant surgery
    • Hepatobiliary surgery
    • Hepatocellular carcinoma, Cholangiocarcinoma, Liver tumors
    • Liver cancer
    • Hepatocellular carcinoma
    • Liver transplant
    • Liver surgery
    • Kindney (renal) transplant
    • Pancreas and islet transplant
    • Kidney disease in solid organ transplant recipients
    • Kidney disease
    • Liver tumors
    • Liver, billary and pancreatic disease
    • Liver disease
    • Liver tumors
    • Liver, billary and pancreatic disease
    • Liver disease
    • Liver failure
    Board Certifications
    • Surgery
    Locations
    • Boston: Massachusetts General Hospital

  • Cosimi, Benedict MD

    617-726-5277

    Accepting New Patients

    Clinical Interests
    • Hepatobiliary surgery
    • Melanoma
    • Gastrointestinal surgery
    • Kidney (renal) transplant
    Board Certifications
    • Surgery
    Locations
    • Boston: Massachusetts General Hospital

Hepatologists/Gastroenterologists

  • Chung, Raymond, MD

    617-643-6006

    Accepting New Patients

    Clinical Interests
    • Hepatitis C virus (HCV)
    • Hepatitis B virus (HBV)
    • Non-alcoholic fatty liver disease
    • Liver transplant
    • Liver cancer
    • Autoimmune hepatitis, Autoimmune liver disease
    Board Certifications
    • Internal Medicine
    • Transplant Hepatology
    Locations
    • Boston: Massachusetts General Hospital

  • Pratt, Daniel, MD

    617-726-3313

    Accepting New Patients

    Clinical Interests
    • Primary Biliary Cirrhosis
    • Primary sclerosing cholangitis
    • Autoimmune hepatitis, Autoimmune liver disease
    • Cirrhosis
    • Hepatitis B
    • Hepatitis C
    • Hepatocellular carcinoma
    • Cholangiocarcinoma
    • Abnormal liver function tests
    • Liver tumors
    Board Certifications
    • Gastroenterology
    Locations
    • Boston: Massachusetts General Hospital

  • Andersson, Karin, MD

    617-726-3524

    Accepting New Patients

    Clinical Interests
    • Liver disease
    • Viral hepatitis
    Board Certifications
    • Gastroenterology
    • Transplant Hepatology
    Locations
    • Boston: Massachusetts General Hospital

  • Corey, Kathleen, MD, MPH

    617-724-0274

    Accepting New Patients

    Clinical Interests
    • Non-alcoholic fatty liver disease
    • Hepatitis C
    • Hepatitis B
    • Primary Biliary Cirrhosis
    • Primary sclerosing cholangitis
    • Liver transplant
    • Hemochromatosis
    • Alpha-1-anti-trypsin disease
    • Cirrhosis
    Board Certifications
    • Internal Medicine
    • Gastroenterology
    • Transplant Hepatology
    Locations
    • Boston: Massachusetts General Hospital

  • Thiim, Michael, MD, MPH

    617-726-3212

    Accepting New Patients

    Clinical Interests
    • Autoimmune hepatitis
    • Cirrhosis
    • Hepatitis C
    • Hepatitis B
    • Liver failure
    • Liver transplant
    • Portal hypertension
    • Diagnostic Endoscopy
    Board Certifications
    • Gastroenterology
    Locations
    • Boston: Massachusetts General Hospital
    • Danvers: The Mass General/North Shore Center for Outpatient Care

  • Rutherford, Anna E. MD, MPH

    617-644-2860

    Accepting New Patients

    Board Certifications
    • Gastroenterology
    • Transplant Hepatology
    Locations
    • Boston: Massachusetts General Hospital

Infectious Disease Specialists

  • Fishman, Jay, MD

    617-726-3812

    Accepting New Patients

    Clinical Interests
    • Infection in immunocompromised hosts
    • Viral and fungal infections
    • Medical education
    • Infections after transplant
    • Molecular diagnostics
    • Infectious diseases
    Board Certifications
    • Infectious Disease
    Locations
    • Boston: Massachusetts General Hospital

  • Kim, Arthur, MD

    617-726-3906

    Accepting New Patients

    Clinical Interests
    • Hepatitis B virus (HBV)
    • Hepatitis C virus (HCV)
    • AIDS and HIV infection
    • HIV/HCV coinfection
    • Substance abuse
    • Travel medicine
    • Immunocompromised patient
    • Immunology
    Board Certifications
    • Internal Medicine
    • Infectious Disease
    Locations
    • Boston: Massachusetts General Hospital

  • Kotton, Camille, MD

    617-724-0082

    Accepting New Patients

    Clinical Interests
    • Vaccines and immunizations
    • Reducing infectious risks in Transplant recipients
    • Immunocompromised patient
    Board Certifications
    • Infectious Disease
    Locations
    • Boston: Massachusetts General Hospital

  • Poznansky, Mark, MD, PhD

    617-726-3906

    Accepting New Patients

    Locations
    • Boston: Massachusetts General Hospital

  • Rosenberg, Eric, MD

    617-724-7519

    Not Accepting New Patients

    Clinical Interests
    • Infectious diseases
    • Clinical microbiology
    Board Certifications
    • Infectious Disease
    Locations
    • Boston: Massachusetts General Hospital

  • El-Khoury, Joseph, MD

    617-726-3906

    Accepting New Patients

    Board Certifications
    • Infectious Disease
    Locations
    • Boston: Massachusetts General Hospital
  • Mansour, Michael, MD, PhD

    617-726-6726

    Accepting New Patients

    Board Certifications
    • Internal Medicine
    • Infectious Disease
    Locations
    • Boston: Massachusetts General Hospital

  • Letourneau, Alyssa, MD

    617-726-3812

    Accepting New Patients

    Clinical Interests
    • Immunocompromised patient
    • Mycobacterial infection
    Board Certifications
    • Pediatrics
    • Internal Medicine
    • Infectious Disease
    Locations
    • Boston: Massachusetts General Hospital

  • Turbett, Sarah, MD

    617-726-3812

    Accepting New Patients

    Board Certifications
    • Internal Medicine
    • Infectious Disease
    Locations
    • Boston: Massachusetts General Hospital

  • Sen, Pritha, MD

    617-726-3812

    Accepting New Patients

    Board Certifications
    • Internal Medicine
    • Infectious Disease
    Locations
    • Boston: Massachusetts General Hospital

Psychiatrists

  • Ivkovic, Ana, MD

    617-726-2984

    Accepting New Patients

    Board Certifications
    • Psychiatry
    Locations
    • Boston: Massachusetts General Hospital

  • Purcell, John, MD

    617-726-1736

    Accepting New Patients

    Clinical Interests
    • Anxiety
    • Depression
    • Psychiatry
    Board Certifications
    • Psychiatry
    Locations
    • Boston: Massachusetts General Hospital

  • Prager, Laura, MD

    617-724-5600

    Accepting New Patients

    Board Certifications
    • Child & Adolescent Psychiatry
    • Psychiatry
    Locations
    • Boston: Massachusetts General Hospital

  • Smith, Felicia, MD

    617-643-6349

    Accepting New Patients

    Clinical Interests
    • Emergency psychiatry
    • Psychosomatic medicine
    Board Certifications
    • Psychiatry
    • Psychosomatic Medicine
    Locations
    • Boston: Massachusetts General Hospital

  • Kolappa, Kavitha, MD, MPH

    617-726-2984

    Accepting New Patients

    Locations
    • Boston: Massachusetts General Hospital

Conditions & Diseases

The links below provide more information about conditions and diseases that might be treated within this program.

  • Alcohol-Induced Liver Disease

    Alcohol-induced liver disease, as the name implies, is caused by excessive consumption of alcohol and is a common, but preventable, disease.

  • Alcoholic Hepatitis

    Hepatitis is the inflammation of the liver, resulting in liver cell damage and destruction. Alcoholic hepatitis is a complex problem and is a precursor to chronic liver disease and cirrhosis.

  • Autoimmune Hepatitis

    Hepatitis is the inflammation of the liver, resulting in liver cell damage and destruction. In autoimmune hepatitis, the body's own immune system destroys liver cells.

  • Biliary Cirrhosis / Bile Duct Cancer

    Biliary cirrhosis is a rare form of liver cirrhosis, caused by disease or defects of the bile ducts.

  • Chronic Liver Disease / Cirrhosis

    Chronic liver disease is marked by the gradual destruction of liver tissue over time. Several liver diseases fall under this category, including cirrhosis of the liver and fibrosis of the liver.

  • Congenital Liver Defects

    Congenital liver defects are rare liver diseases present at birth such as biliary atresia, when the bile ducts are absent or have developed abnormally, and choledochal cyst, a malformation of the hepatic duct that can obstruct flow of bile in infants.

  • Hepatitis A

    Hepatitis A is a highly contagious and sometimes serious liver disease caused by the hepatitis A virus.

  • Hepatitis B

    Hepatitis B is a blood-borne microorganism transmitted by exposure to the hepatitis B virus through infectious body fluids.

  • Hepatitis C

    Hepatitis C (once called non-A, non-B hepatitis) is a liver disease caused by a recently identified blood-borne virus.

  • Liver Tumors

    Tumors are abnormal masses of tissue that form when cells begin to reproduce at an increased rate. The liver can grow both non-cancerous (benign) and cancerous (malignant) tumors.

Research

Immunosuppression Minimization/Withdrawal

In spite of advances over the last 50 years in anti-rejection medications, the side effects of long-term immunosuppressive therapy remain a major problem for post-transplant patients. The MGH Transplant Center is participating in trials which allow transplant patients to take fewer or no medications.


Hepatitis C Treatment

Hepatitis C infection can return after liver transplantation, occasionally causing liver damage severe enough to require re-transplantation. The MGH Transplant Center offers the latest FDA-approved anti-viral therapies and participates in clinical trials utilizing promising new agents. 

For more information about hepatitis C clinical trials, call 617-724-3836.


Liver Perfusion Device

Innovative studies are underway to improve the preservation and function of organs from deceased donors. Perfusion devices may help solve the organ shortage by uncovering alternative sources for organs. The MGH Transplant Center is a leading site in the field of organ perfusion and preservation.


HOPE Act: HIV+ Donors for HIV+ Recipients

Until 2015, transplanting organs from HIV positive donors was not allowed under the National Organ Transplant Act of 1984. However, since HIV treatments have improved and HIV positive transplant recipients have done well after transplant, the HIV Organ Policy Equity (HOPE) Act was recently passed. The HOPE Act allows organs from HIV positive donors to be transplanted into HIV positive recipients. These are organs that would have been discarded before the HOPE Act was passed. The MGH Transplant Center is one of the few hospitals in the United States doing these transplants.


Hepatitis C Positive Liver Transplant for Hepatitis C Negative Recipients

Currently there are more available hepatitis C positive deceased donors in New England than there are recipients.  With the arrival of new anti-viral agents Hepatitis C cure rates are almost at 100%.  Under a clinical trial protocol we will be transplanting livers from donors who are positive for hepatitis C virus into select recipients who are not infected with the hepatitis C virus. Patients who enter into this trial receive immediate pre-emptive treatment for hepatitis C. This will allow these selected recipients to be receive a transplant more quickly, avoiding many consequences of prolonged time on the waitlist.

News

  • From the hospital to the Himalayas: One patient's journey - 11/2/2018, Mass General

    South Sudan is the world’s youngest nation. The landlocked country in East-Central Africa was forged in the shadow of a 14-year bloody civil war. Amid this chaos, many dedicated individuals have helped refugees, including Bruce Parmelee of Binghamton, New York.

  • Threat grows from liver illness tied to obesity - 6/13/2014, Mass General

    Kathleen Corey, MD, director of the Massachusetts General Hospital Fatty Liver Clinic and co-director of the Mass General Weight Center, discusses the link between obesity and the rise in liver diseases such as nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease.

  • New year, new lease on life - 1/10/2014, Mass General

    When the call came in at 4 am, just before Christmas, Eric Fritz, 38, of Liverpool, N.Y., was so surprised he made the transplant coordinator tell him twice. After a year of waiting, he had a donor liver.

  • Neighborhood support inspires transplant recipient John Morelli to help others - 2/4/2013, Mass General

    A local community’s support for a transplant recipient motivated him to create an organization that helps others.

  • Transplant Center recognized for organ donation rate - 12/15/2009, Mass General

    The Department of Health and Human Services awarded the Transplant Center a Medal of Honor for its outstanding achievements in organ donation, including a donation rate of 75 percent or more eligible donors.

  • Transplant Center recognized as a leader in patient education - 9/8/2009, Mass General

    Clinicians at the Transplant Center received a National Health Information Award for developing an outstanding patient education book and streamlining the patient evaluation process.

Video

  • A Brother's Love

    A Brother's Love

    Meet Nicola and Steve, a brother and sister with an inspiring story. With the help of Massachusetts General’s Living Liver Donor program, Steve gave the gift of life and a happy future to his sister, Nicola.

  • Paying It Forward

    Paying it Forward

    While in college, Phil needed a liver transplant. He turned to Massachusetts General’s Transplant Program. Now he is an aspiring physician, and ready to pay it forward to others. See how Phil’s experience changed his life and future forever.

Contact

Contact Us

Liver Transplant Program

55 Fruit Street Boston, MA 02114
  • Near Public Transit
  • Accessible
  • Phone: 877-716-8440

Mass General specialists also see patients for liver transplant evaluation at:
Cooley Dickinson Hospital
30 Locust St. (Route 9)
Northampton, MA 01060

Request an appointment Refer a patient

Call to request an appointment or referral: 877-716-8440

Back to Top