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At the Massachusetts General Hospital Fireman Vascular Center, our world-renowned research advances patient care in the field of stroke.
Clinical research in the Stroke Program at the Massachusetts General Hospital Fireman Vascular Center combines leading research with patient care to develop innovative options to prevent and treat stroke.
View a sample of our clinical research below.
Investigation of Cortical Spreading Depolarizations in Patients with Acute Brain Injury
This is a pilot study on the role of cortical spreading depolarizations in delayed deterioration after aneurysmal subarachnoid hemorrhage, malignant hemispheric stroke, and traumatic brain injury.
Eric Rosenthal, MD
Stroke Hyperglycemia Insulin Network Effort
Antihypertensive Treatment of Acute Cerebral Hemorrhage: A Phase III Randomized Multicenter Clinical Trial of Blood Pressure Reduction for Hypertension in Acute Intracerebral Hemorrhage
Study of Deferoxamine Mesylate in Intracerebral Hemorrhage
TRanscranial Ultrasound Imaging for The Evaluation of Hematoma Expansion and Neurologic Deterioration in Patients with Acute IntraCerebral Hemorrhage
Advanced Neuroimaging to Detect Cerebral Amyloid Angiopathy
Measurement of Biomarkers in Cerebrospinal Fluid in Cerebral Amyloid Angiopathy
Stroke Database/Research Registries
Acute Brain Injury Tissue Repository
Glyburide Advantage in Malignant Edema and Stroke
Ethnic/Racial Variations of Intracerebral Hemorrhage
Genetics of Cerebral Hemorrhage with Anticoagulation
Monitoring of cerebral blood volume and oxygenation with time-domain near-infrared spectroscopy in traumatic brain injury and stroke patients
A multi-center, Phase 2, dose-escalation study to determine the safety and tolerability of 3K3A-APC, a recombinant variant of human activated protein C (APC), in combination with tissue plasminogen activator (tPA) in moderately severe acute hemispheric ischemic stroke.
Genes Affecting Stroke Risk and Outcome Study
Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) Sample Repository
Statins Augment smalL Vessel function and improve Outcomes in acute ischemic strokes
MR WITNESS: A Phase IIa Safety Study of Intravenous Thrombolysis with Alteplase in MRI-Selected Patients
GORE® Carotid Stent Clinical Study for the treatment of carotid artery stenosis in patients at increased risk for adverse events from carotid endarterectomy
Investigation of flow altered, short transcervical carotid artery stenting in patients with significant carotid artery disease with filter (The ROADSTER Plus Study)
Richard Cambria, MD, andChristopher Kwolek, MD
Advanced MRI Neural Network Analysis for Predicting Recovery of Consciousness after Traumatic Coma
This is a imaging study enrolling patients with severe TBI. Primary aim is to determine if advanced structural/functional neuroimaging data acquired acutely will predict recovery of consciousness 6 months post-injury. Secondary aims include correlation of clinical, MRI, EEG, and genetic/metabolomic data.
Brian Edlow, MD
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
This is a feasibility study of an intracortical neural interface system for persons with tetraplegia.
Leigh Hochberg, MD, PhD
Discarded carotid and femoral specimens after endarterectomy
We will study femoral and carotid endarterectomy specimens for imaging and histology analysis.
Farouc Jaffer, MD, PhD
Clinical Proteomics Research on the Brain
The purpose of this study is to identify neuroprotective proteins in patients with acute brain injuries including stroke, and neurological or vascular conditions other than acute stroke.
MingMing Ning, MD
An Open-label Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of SAGE-547 Injection as Adjunctive Therapy in the Treatment of Adults with Super-Refractory Status Epilepticus
This is an open-label study to evaluate the efficacy and tolerability of 5-day infusion of SAGE-547 (allopregnanolone) in subjects with super-refractory status epilepticus (SRSE).
Platelet-Oriented Inhibition in New TIA and minor ischemic stroke (POINT) Trial
Study aims to investigate whether taking a combination of aspirin and plavix can help lower risk of stroke, MI, and other complications on the recovery of a patient who expierienced a TIA or minor ischemic stroke.
Scott B. Silverman, MD
Multimodal Outcome Characterization (MOCHA) in Comatose Cardiac Arrest Patients
A pilot study to evaluate the combination of pictures of the brain with recordings of electrical signals from the brain to understand brain recovery of patients who are in coma after cardiac arrest and who are treated with cooling.
Ona Wu, PhD
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