Investigators

The Krantz Family Center for Cancer Research has a dedicated faculty of over 50 independent investigators and 500 students, postdoctoral scientists, research scientists and technologists, committed both to fundamental discovery and to its application in cancer. Research laboratories span from the fundamental biology of cellular proliferation to the molecular analysis of patient-derived clinical specimens, and from the creation of novel drug and immune therapies to the integration of AI-based algorithms for high throughput data analysis.

View our investigators below, and browse faculty by research theme and disease area.

Krantz Family Center for Cancer Research Leadership

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Daniel A. Haber, MD, PhD
Director, Krantz Family Center for Cancer Research
Director, Mass General Cancer Center
Kurt J. Isselbacher Professor of Oncology (Medicine)
Investigator, Howard Hughes Medical Institute

Raul Mostoslavsky, MD, PhD
Scientific Director, Krantz Family Center for Cancer Research
Laurel Schwartz Professor in Medicine in the Field of Oncology
Professor of Medicine

Andrea I. McClatchey, PhD
Director for Academic Affairs, Krantz Family Center for Cancer Research
Poitras Family Endowed Chair in Oncology
Professor of Pathology

Nir Hacohen, PhD
Director, Center for Cancer Immunology, Krantz Family Center for Cancer Research
Director, Center for Cell Circuits, Broad Institute of Harvard and MIT
David P. Ryan Endowed Chair in Cancer Research
Professor of Medicine

Krantz Family Center for Cancer Research Faculty

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Nabeel Bardeesy, PhD
John R. Gallagher III and Katherine A. Gallagher Endowed Chair in Gastrointestinal Cancer Research
Associate Professor of Medicine

Research topics include: pancreatic ductal adenocarcinoma.

Liron Bar-Peled, PhD
Assistant Professor of Medicine

Research topics include: Transcription factor NRF2, anti-oxidant response, stress signaling.

Lloyd Bod, PhD
Assistant Professor of Medicine

Research topics include: phenotypic and functional B cell states within tumors, B cell response and cancer immunotherapies.

Genevieve M. Boland, MD, PhD
Vice Chair for Research, Department of Surgery
MGH Research Scholar 2023-2028
Associate Professor of Surgery

Research topics include: Melanoma, Immunotherapy, Surgery, Targeted Therapy, Biomarker, Adjuvant, Neoadjuvant.

Priscilla K. Brastianos, MD
Terry and Jean de Gunzburg MGH Research Scholar 2021-2026
Associate Professor of Medicine (Neuro-Oncology)

Research topics include: genomic drivers of human brain tumors.

Ryan Corcoran, MD, PhD
Director, Tucker Gosnell Center for Gastrointestinal Cancers
Mark J. Kusek Endowed Chair in Colorectal Cancer
Associate Professor of Medicine

Research topics include: developing new and effective therapies for gastrointestinal cancers.

Shadmehr (Shawn) Demehri, MD, PhD
MGH Research Scholar 2023-2028
Associate Professor in Dermatology (Cutaneous Biology Research Center)

Research topics include: role of the immune system in regulating the early stages of cancer development.

Andrew Elia, MD, PhD
Assistant Professor of Radiation Oncology

Research topics include: DNA damage response; Replication stress; Ubiquitination; Quantitative proteomics.

Leif Ellisen, MD, PhD
Director, Cancer Center Program in Breast Medical Oncology
Nelson Family and Jerry Younger, MD Endowed Chair in Breast Cancer Research
Professor of Medicine

Research topics include: P53 and human tumorigenesis; breast cancer.

David Fisher, MD, PhD
Director, Cancer Center Melanoma Program
Director, Cutaneous Biology Research Center
Lancer Professor of Dermatology
Edward Wigglesworth Professor and Chair of Dermatology

Research topics include: cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood.

Francesca Gazzaniga, PhD
Assistant Professor of Pathology (Molecular Pathology Unit)

Research topics include: gut microbiota, microbiome, anti-tumor immunity, immunotherapy, immune checkpoint inhibitors

Gad A. Getz, PhD*
Director of Bioinformatics, Cancer Center and Pathology
Director of Cancer Bioinformatics, Broad Institute of Harvard and MIT
Paul Zamecnik, MD Endowed Chair in Oncology Basic Research
Professor of Pathology

Research topics include: cancer genome analysis.

Timothy Graubert, MD
Director, Cancer Center Program in Hematologic Malignancies
Hagler Family Endowed Chair in Hematologic Malignancies
Professor of Medicine

Research topics include: molecular basis of human blood cancers, including acute myeloid leukemia and myelodysplastic syndromes.

Doğa C. Gülhan, PhD
Faculty Member

Research topics include: Genomic Instability, Cancer Genomics, Mutational Signatures, Computational Biology, Machine Learning, Cancer Diagnostics, Circulating Tumor DNA, Tumor evolution.

Wilhelm Haas, PhD
Assistant Professor of Medicine

Research topics include: quantitative mass spectrometry-based proteomics to study the cellular pathways that characterize cancer cells.

Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.

Research topics include: developing new and unbiased strategies to understand basic immune processes and immune-mediated diseases, with an emphasis on the innate immune system.

Aaron Hata, MD, PhD
Assistant Professor of Medicine

Research topics include: understanding the biological underpinnings of sensitivity and resistance to kinase inhibitor targeted therapies in lung cancers with specific genetic abnormalities (EGFR mutations, ALK translocations, KRAS mutations).

Konrad Hochedlinger, PhD**
Gerald and Darlene Jordan Endowed Chair for the Center for Regenerative Medicine
Professor of Medicine (Genetics)

Research topics include: pluripotency and nuclear reprogramming.

Hanno Hock, MD, PhD**
Brant Carleton Endowed Chair in Acute Myeloid Leukemia Research
Assistant Professor of Medicine

Research topics include: transcription factors in blood development and leukemia.

William L. Hwang, MD, PhD
Assistant Professor of Radiation Oncology (Center for Systems Biology)

Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.

A. John Iafrate, MD, PhD*
Austin L. Vickery, Jr. Professor of Pathology
Deputy Chair, Department of Pathology

Research topics include: bringing new genetic technologies to cancer diagnostics and applying them to improve the practice of pathology.

Othon Iliopoulos, MD
Associate Professor of Medicine

Research topics include: understanding the biochemical mechanisms of cancer angiogenesis and cancer metabolism in order to identify and validate new targets for treatment of Renal Cell Carcinoma (RCC).

Max Jan, MD, PhD
Assistant Professor of Pathology

Research topics include: targeted protein degradation, chemical biology, functional genomics, cellular immunotherapy.

Russell Jenkins, MD, PhD
Assistant Professor of Medicine

Research topics include: PD-1, CTLA-4, immunotherapy, tumor microenvironment, organotypic tumor spheroids, 3D culture, microfluidics, cytokines.

David Langenau, PhD*
Atul K. Bhan, MBBS, MD, Endowed Chair in Experimental Pathology
Professor of Pathology (Molecular Pathology Unit)

Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.

Michael S. Lawrence, PhD
Assistant Professor of Pathology

Research topics include: using computation as a powerful microscope to study the processes of DNA damage and repair, gene expression and genome replication, and cancer driver genes.

Abner Louissaint, Jr., MD, PhD
Aziz and Nur Hamzaogullari Endowed Scholar in Hematologic Malignancies
Associate Professor of Pathology (Molecular Pathology Unit)

Research topics include: Unraveling biology of lymphomas, especially B-cell lymphomas; defining prognostic markers and therapeutic vulnerabilities via molecular characterization of patient-deived xenograft and in-vitro models of human lymphoma.

Shyamala Maheswaran, PhD
Mary B. Saltonstall Endowed Chair in Oncology
Professor of Surgery

Research topics include: tumorigenesis, breast cancer and cancer genetics.

Robert Manguso, PhD
Co-Director, Tumor Immunotherapy Discovery Engine, Broad Institute
Assistant Professor of Medicine

Research topics include: cancer immunology, immunotherapy, functional genomics, in vivo screening.

Marcela V. Maus, MD, PhD
Director, Cancer Center Program in Cellular Immunotherapy
Paula J. O’Keeffe Endowed Chair in Thoracic Oncology
Associate Professor of Medicine

Research topics include: designing and evaluating next generation genetically-modified (CAR) T cells as immunotherapy in patients with cancer.

Andrea I. McClatchey, PhD
Director for Academic Affairs, Krantz Family Center for Cancer Research
Poitras Family Endowed Chair in Oncology
Professor of Pathology

Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity.

Peter Miller, MD, PhD
Assistant Professor of Medicine

Research topics include: clonal hematopoiesis, leukemia, PPM1D, stem cells.

David T. Miyamoto, MD, PhD
Assistant Professor of Radiation Oncology

Research topics include: prostate cancer, biomarkers, circulating tumor cells (CTCs).

Raul Mostoslavsky, MD, PhD
Scientific Director, Krantz Family Center for Cancer Research
Laurel Schwartz Professor in Medicine in the Field of Oncology
Professor of Medicine

Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair.

Mo Motamedi, PhD
James and Patricia Poitras Endowed Chair in Cancer Research
Assistant Professor of Medicine

Research topics include: RNA-mediated epigenetic gene silencing.

Eugene Oh, PhD
Assistant Professor of Medicine

Research topics include: ubiquitin, cell signaling, gene expression, chromatin, cell cycle

Christopher Ott, PhD
Assistant Professor of Medicine

Research topics include: cancer epigenetics, chromatin chemical biology, gene expression control in leukemia and lymphoma.

Shiv Pillai, MD, PhD
Professor of Medicine

Research topics include: B cell Development and Lineage Commitment; A Novel Cell Surface Acetylation/Deacetylation Paradigm for Regulating Humoral Immunity and Development; Characterizing Peripheral Human B cells and B cells in Patients with Chronic Lymphocytic Leukemia.

Luca Pinello, PhD
Associate Professor in Pathology (Molecular Pathology Unit)

Research topics include: using innovative computational approaches and cutting-edge experimental assays to systematically analyze sources of genetic and epigenetic variation and gene expression variability that underlie human traits and diseases.

Esther Rheinbay, PhD
Assistant Professor of Medicine

Research topics include: identifying and functionally characterizing non-coding drivers mutations in cancer and the role of Y chromosome loss in cancer.

Miguel Rivera, MD*
Thomas F. and Diana L. Ryan MGH Research Scholar 2019-2024
Associate Professor of Pathology (Molecular Pathology Unit)

Research topics include: gene regulation in cancer, chromatin, epigenomics, developmental pathways in cancer.

Moshe Sade-Feldman, PhD
Faculty Member

Research topics include: Immuno-oncology, single-cell multi-omics, systems-biology approach for the identification of therapy resistance mechanisms, melanoma, HNSCC, NSCLC.

Ioannis Sanidas, PhD
Faculty Member

Research topics include: Retinoblastoma protein (RB); RB target genes; RB mediated chromatin regulation; cell cycle control; CDK inhibitors.

Debattama Sen, PhD
Assistant Professor of Medicine

Research topics include: regulation of T cell dysfunction, CD8+ T cells, epigenetic approaches for T cell engineering, immunology, systems biology and epigenomics.

Dennis Sgroi, MD*
Executive Vice-Chair of Pathology
Professor of Pathology

Research topics include: Human Breast Cancer Anti-Hormonal Resistance.

Toshihiro Shioda, MD, PhD
Associate Professor of Medicine

Research topics include: human germ cell development and germ cell tumors; non-genetic inheritance involving epigenetic reprogramming in germ cells.

Shannon Stott, PhD
d’Arbeloff MGH Research Scholar 2022-2027
Associate Professor of Medicine

Research topics include: Circulating tumor cells; microfluidics and control of the cell microenvironment; imaging.

Mario Luca Suva, MD, PhD*
Vice-Chair of Pathology for Research
Director, Molecular Pathology Unit
Janet and William Ellery James MGH Research Scholar 2020-2025
Associate Professor of Pathology

Research topics include: biology of brain tumors, in particular glioblastoma and oligodendroglioma.

David Sweetser, MD, PhD
Chief of Medical Genetics and Metabolism, Department of Pediatrics
Leslie Meyer and Lewis Ball Holmes Chair in Genetics and Teratology
Assistant Professor of Pediatrics (Pediatrics, Genetics)

Research topics include: leukemia, tumor suppressor gene, cancer genetics, stem cell, targeted therapy.

David T. Ting, MD
Associate Clinical Director for Innovation, Cancer Center
Amin and Zebunisha Juma Endowed Chair in Oncology
Associate Professor of Medicine

Research topics include: Pancreatic ductal adenocarcinoma (PDAC).

Shobha Vasudevan, PhD**
Associate Professor of Medicine

Research topics include: Translation, Quiescence, Ribosomes, RNA modification, Resistance, Non-coding RNAs, AU-rich elements, Cytokines, Stress signals.

Alexandra-Chloé Villani, PhD
Assistant Professor of Medicine (Center for Immunology & Inflammatory Diseases)

Research topics include: developing and implementing single-cell ‘omics’ strategies and systems immunology approaches to further unravel the players and rules governing human immune response regulation as a foundation for deciphering human traits and diseases.

Browse Faculty by Theme

Cancer Cell Biology