Patil Laboratory: Sarita Patil, MD

Overview

My laboratory seeks to understand how allergies develop and how they can be effective treated by understanding the role of antibodies in allergy and tolerance. Our translational research approach leverages the application of cutting edge, sample sparing techniques to understand clinical manifestations of disease, in both children and adults. To that end, we have pioneered the application of fluorescent multimers to identify rare, allergen-specific B cells, combined with single cell B cell receptor sequencing, followed through to structural characterization of antibodies. Our work has led to the identification of neutralizing antibodies and their role in sustained responses after therapy, as well as the identification of convergent, or public antibodies. From this work, we have a clearer insight into antibodies from individuals but also on a population level. 

Lab Members

Principal Investigator

Sarita Patil, MD Principal Investigator, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital Assistant Physician, Massachusetts General Hospital Assistant Professor of Medicine, Harvard Medical School

Postdoctoral Fellows

Tarun Keswani, PhD
Moumita Bhowmick, PhD

Research Technician

Orlee Marini-Rapoport

Publications

List of publications