Ebru Oral, PhD, was inducted into the National Academy of Inventors' Fellow Program in November 2021.
Explore the Harris Orthopaedics Laboratory
The Harris Orthopaedics Laboratory (HOL) has over five decades of experience in addressing problems in adult reconstructive surgery by innovating new surgical techniques, devices, joint implant designs, and joint implant materials. Notably, several formulations of highly cross-linked ultrahigh molecular weight polyethylene (UHMWPE), stabilized by re-melting or vitamin E, were developed for large scale usage in implant manufacturing in this laboratory and have since changed the landscape of joint replacement by reducing the number of wear particles and instances of osteolysis associated with total joint implants. After about a decade of use, these materials have become the gold standard in joint replacement, especially of the hip.
One focus area of the laboratory today is advancing material development in joint repair and replacement. Under the direction of Orhun K. Muratoglu, PhD, the pre-clinical material research team develops novel UHMWPEs for improving the longevity of joint implants and expanding the use of joint replacement safely to younger and more active patients. Another cutting-edge area is the development of non-degradable hydrogel-based materials for integrative and mechanically feasible repair of cartilage defects at an early degenerative state. The materials research team collectively brings experience in material and polymer science, polymer chemistry, biomaterials and biomechanics testing and bench-to-clinic implant development as well as follow-up testing of explanted devices to analyze in vivo effects.
While the HOL has a strong and successful history in joint replacement, our current projects include applying our expertise to other musculoskeletal systems such as the hydrogel-based treatment of degenerative spine conditions and improving the mechanical and integrative properties of bone grafts.
Another major area of focus is follow-up and analysis of clinical implant performance to provide evidence-based feedback to patients and clinicians. Under the direction of Henrik Malchau, MD, PhD, the clinical research team develops local and regional implant registries in collaboration with orthopaedic surgeons in arthroplasty, spine, hand, sports medicine and trauma. We also conduct prospective clinical studies nationally and internationally on alternative bearing materials and new implant designs, which provide fast and valuable information on the performance of newly developed implants and helps compare them to historical standards. These studies also can provide feedback on surgical techniques and skills to improve clinical outcomes.
Harris Orthopaedic Investigators are authors of more than 75 patents worldwide in the following area:
- Methods for Making Oxidation Resistant Polymeric Materials
- Mosaicplasty Constructs
- Highly Crystalline Polyethylene
- Highly Crystalline Crosslinked Oxidation Resistant Polyethylene
- Methods and Devices for Knee Joint Replacement with Anterior Cruciate Ligament Substitution
- High Temperature Melting
- Radiation and Melt Treated Ultra High Molecular Weight Polyethylene Prosthetic Devices
- PVA-PAA Hydrogels
- Oxidation Resistant Homogenized Polymeric Material
- Selective Controlled Manipulation of Polymers
- High Modulus Crosslinked Polyethylene with Reduced Residual free Radical Concentration Prepared below the Melt
Our research projects are mainly in:
- Material and animal model development for arthroplasty and resurfacing
- Material and animal model development for focal cartilage defect repair
- Biomaterials and biomechanical testing and device development
- Clinical evaluation of new implants and materials
- Evaluation of new surgical techniques and technology
- Evaluation of quality control measures and cost effectiveness analysis
- Development and evaluation of methods for measuring performance, wear, stability, etc. from clinical radiographs
The Harris Orthopaedics Laboratory (HOL) offers comprehensive support for developing orthopaedic implants. We engage in partnerships and provide services in the areas of design, concept development, characterization and post-market surveillance.
- Device Lifecycle Testing (Wear, Fatigue, Creep)
- In vitro, In vivo Testing and Cadaver Laboratory
- Implant Design FEA and Computational Modeling
- Testing per FDA Guidance Documents
- Clinical Studies and Post-Market Surveillance
Meet our Team
Learn more about the team at the Harris Orthopaedics Laboratory.
Improvements in Outcomes for Total Joint Patients
- Jan | 11 | 2021
Alireza Borjali, PhD, of the Harris Orthopaedics Laboratory, was awarded the 2021 Orthopaedic Research Society William H. Harris award for his publication, "Detecting total hip replacement prosthesis design on plain radiographs using deep convolutional neural network."
- Mar | 15 | 2019
Ebru Oral, PhD, inducted to College of Fellows for the American Institute for Medical and Biological Engineering
Ebru Oral, PhD, a Principal Investigator with the Harris Orthopaedics Laboratory, was inducted to the College of Fellows for the American Institute for Medical and Biological Engineering (AIMBE).
- Aug | 8 | 2018
William Harris, MD, director emeritus of the Department of Orthopaedics, has received the 2018 Distinguished Contributions to Orthopaedics Award from the American Orthopaedic Association.