Patrick Purdon, PhD, and Emery Brown, MD, PhD, review a patient's EEG patterns to determine their brain state while under general anesthesia.
Patrick Purdon, PhD, and Emery Brown, MD, PhD, review a patient's EEG patterns to determine their brain state while under general anesthesia.

Overview

anesthesia research
Anesthesia research

The Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital is one of the leading research departments of anesthesia in the United States and in the world.

We are committed to conducting innovative research with the goal of improving patient outcomes, quality of life and overall care.

Our Researchers

More than 200 researchers are part of our research program. The department receives a large number of research grants from various federal agencies, foundations and industries.

Our program includes mentored investigators who are supported through a career-building research experience by being paired with a senior research faculty member. The mentor process is designed to enhance the junior investigator’s ability to attain advanced research skills and prepare them to independently compete for extramural funding.

Research Topics

Our research topics include:

  • Biomedical engineering
  • Cardiovascular research
  • Critical care
  • Epidemiology
  • Genetics
  • Mechanisms of general anesthesia
  • Neuroscience
  • Pain
  • Pulmonary research
  • Quality and safety
  • Simulation

 Learn more about our programs in:

Research Centers and Units

The Department of Anesthesia, Critical Care and Pain Medicine comprises multi-principal investigator research centers and units that conduct innovative and collaborative research.

View our research centers and units

Anesthesia Research

Anesthesia research

Investigators in the Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital conduct innovative research in the field of anesthesia aimed to advance patient safety during surgical procedures and improve the quality of life for patients.

 

Biomedical Engineering Researchers

Epidemiology Researcher

Genetics Researcher

Mechanisms of General Anesthesia Researchers

Neuroscience Researchers

Pulmonary Researchers

Quality and Safety

  • Karen Nanji, MD, MPH* (clinical)

 

*Mentored investigator

Critical Care Research

Lorenzo Berra, MD (left) with researcher
Lorenzo Berra, MD (left) with researcher

Our multidisciplinary team of investigators in the Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital conducts innovative basic, clinical and translational research aimed to improve the care of critically ill patients.

Cardiovascular Researchers

Critical Care Researchers

Epidemiology Researcher

Genetics Researcher

Neuroscience Researchers

Pulmonary Researchers

Quality and Safety

  • Karen Nanji, MD, MPH* (clinical)

 

*Mentored investigator

Pain Research

Cell culture

Researchers in the Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital are committed to advancing the evaluation and treatment of pain through innovative research. Our researchers lead numerous national and international clinical trials evaluating new procedures, devices and medications for the treatment of pain.


Genetics Researcher

Neuroscience Researchers

Pain Researchers

Quality and Safety

  • Karen Nanji, MD, MPH* (clinical)


*Mentored investigator

Centers & Units

The Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital comprises centers and units that conduct innovative and collaborative research.

  • Anesthesia Center for Critical Care Research

    Research in the Anesthesia Center for Critical Care Research (ACCCR) focuses on developing and testing new ways to make problematic produres in the intensive care unit safer and more effective.

  • Center for Medical Simulation

    The Center for Medical Simulation (CMS) offers educational and research opportunities in many medical disciplines and in the social sciences. It is widely known for its innovative and high-quality programs, including the Institute for Medical Simulation, in which educators and clinicians from around the world participate in courses to learn how to use simulation to improve safety, quality and education in health care.

  • Center for Translational Pain Research

    The Center for Translational Pain Research strives to improve the clinical management of patients experiencing acute, chronic and cancer pain conditions. The center uses a multidisciplinary and mechanism-based research approach to clinical pain management together with basic science pain research.

  • Mallinckrodt Center for Molecular Pharmacology Research

    Research in the Mallinckrodt Center for Molecular Pharmacology Research focuses on eludicating the molecular mechanisms by which general anesthetics act to produce anesthesia and its side effects. Our work aims to create better treatments and ultimately a safer and more efficient practice of anesthesiology.

  • Medical Device Plug-and-Play Interoperability Program

    The Medical Device Plug-and-Play (MD PnP) Interoperability Program is a recognized leader in the development of the concepts and capabilities for integrated clinical environments of the future. Working with a geographically-dispersed team of collaborators, the program has developed an open interoperable medical device clinical research platform, sharable databases, tools and applications. The goal is to enable a broader community of researchers and manufacturers to implement medical device interoperability aimed to improve patient safety and health care efficiency.

  • Neuroscience Statistic Research Lab

    The Neuroscience Statistic Research Lab is a collaboration of investigators from Mass General, Harvard, MIT and Boston University that uses a systems neuroscience approach in studying how the state of general anesthesia is induced and maintained. The long-term goal of our research is to establish a neurophysiological definition of anesthesia; safer, site-specific anesthetic drugs, and to develop better neurophysiologically-based methods for measuring depth of anesthesia.

  • Pulmonary Functional Imaging and Bioengineering Research Lab

    The Pulmonary Functional Imaging and Bioengineering Research Lab is a multidisciplinary, interdepartmental group of investigators who strive to advance the understanding of whole-organ physiology and pathophysiology of the human lung through the development and implementation of advanced imaging techniques, sophisticated mathematical and computer modeling, and bioengineering.

News & Publications

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