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The Massachusetts General Hospital Cancer Center's Bone Marrow Transplant (BMT) Program is world-renowned for its expertise in bone marrow transplantation to treat a wide variety of hematological conditions. We also conduct leading-edge clinical and translational research to develop innovative strategies for improving the outcomes of patients undergoing bone marrow transplant.
Our program is advancing clinical care and research in several areas and these include:
The Bone Marrow Transplant Program benefits from a close association with the Transplant Biology Research Center. We are dedicated to understanding the basic immunologic mechanisms through which specific tolerance can be induced for solid organ transplants by performing combined bone marrow and organ transplants. We are also conducting investigations into the mechanism of the graft versus tumor effect of BMT and how it can be separated from graft versus host disease to improve overall outcomes for our patients.
Our BMT team's multidisciplinary approach to evaluation, management, and treatment provides each patient with individually tailored care.
Director, BMT ProgramAssistant Professor of Medicine, Harvard Medical School
Bone marrow — the soft, spongy tissue inside the large bones in the body — can be affected by a variety of blood disorders, blood cancers and other diseases. Hematopoietic (blood) stem cells live in the bone marrow and give rise to all of the other components of the blood.
Bone marrow or stem cell transplants are performed for several reasons:
1. To rescue and restore blood components after the patient has received high doses of chemotherapy or radiation as treatment 2. To replace the patient’s blood system because their own is failing 3. To replace the patient’s blood system in order to grow a new immune system which can attack the patient’s cancer
The terms bone marrow transplant and stem cell transplant are used somewhat interchangeably. For various reasons, one may receive bone marrow or blood stem cells.
There are two basic types of bone marrow transplant procedures:
Following a bone marrow transplant, the donated stem cells start making new blood cells and other components from within the bone marrow.
Clinical trials are research studies of new drugs, new combinations of drugs or already approved drugs being studied to treat patients in new/different ways. They may include new drug doses or new ways (schedules) to give the drugs. Clinical trials are run under strict guidelines. Their purpose is to help find out whether new cancer treatments are safe and effective or better than the standard (current) treatment. At Massachusetts General Hospital Cancer Center, there are several clinical trials open for the treatment of cancer that use the latest in cancer treatments.
Cancer is increasingly becoming a disease in which the genetic make-up of each individual cancer drives therapy. The Bone Marrow Treatment Program has access to clinical trials involving these targeted therapy approaches.Contact Yi-Bin Chen, MD, Director of Clinical Research, with questions about Bone Marrow Transplant Clinical Trials: email@example.com
If you have any questions or would like to speak with one of our physicians, please call the Bone Marrow Transplant Program at (617) 724-1124.
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