Photo of Patricia L. Musolino, MD, PhD

Patricia L. Musolino, MD, PhD


Accepting New Patients




Centers & Specialties

MassGeneral Hospital for Children

Vascular Center

Clinical Interests
  • Neurocritical Care
  • Leukodystrophies
  • Pediatric stroke
  • Vascular neurology
  • Neurogenetics
Medical Education
  • PhD, Austral University
  • MD, University of Buenos Aires School of Medicine
  • Residency, Brigham and Women's Hospital|Residency, Miami Children's Hospital
  • Fellowship, Massachusetts General Hospital
Board Certifications
  • Neurology with Special Qualifications in Child Neurology
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Centene/Celticare
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • OSW - Vermont
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
Patient Age Group
Adult and Pediatric

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Patricia Musolino MD, PhD is a critical care and vascular neurologist with expertise in neurogenetics and neuroinflammation. Former Partners Neurology residency graduate she stayed at MGH for neurocritical care and vascular neurology fellowship and she is currently junior faculty in the divisions of Neurocritical Care, Stroke and Child Neurology. She cares for patients in the Neuroscience Intensive Care Unit, the Emergency Department and the outpatient Pediatric Stroke Clinic. Her research career started during her MD and PhD years in Buenos Aires and continued while a senior resident and fellow as an NINDS R25 post-doctoral clinical research scholar. Dr. Musolino translational and clinical research, directed by Dr. Eichler, explores the relationship of mutant genes to specific biochemical defects and their contribution to neurodegeneration. More specifically, her research focus is upon understanding the permeability of brain endothelium to inflammatory cells. Work on monogenic disorder has allowed her to model the impact of single genes upon brain microvessels and their biology both in-vitro and in-vivo. Using advanced imaging (MRI, MRI-PET and NIRS) techniques she is able to extend these insights to patients and Dr. Musolino is now exploring new therapeutic targets that ameliorate endothelial dysfunction.

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Research & Publications

Research Summary
Our translational and clinical research lab, directed by Dr.Eichler, explores the relationship of mutant genes to specific biochemical defects and their contribution to neurodegeneration and inflammation. More specifically, my research focuses on how genetically determined endothelial cell-to-cell interactions underlay a broader category of vascular diseases and can be treated by molecular interventions. Cerebrovascular diseases have been traditionally approached in categories of disease where normal physiology is altered by rupture, occlusion or inflammatory processes affecting the brain vessels. A number of single gene disorders recently described have dramatically expanded our understanding of some of the mechanisms underlying the pathophysiology of stroke and vascular malformations (i.e: CADASIL, CARASIL, Loeys-Dietz, HHT, inherited thrombophilias and ACTA2). The multiple layers of the vascular system are integrated structurally where functions are maintained and governed by discrete molecular signaling and control mechanisms populations. A tailored approach to their normal and pathological mechanisms, based on genetic and molecular biology, is now within the reach of our conceptual framework and experimental methods. Studying monogenic disorders enhances our knowledge of cerebrovascular diseases and allow for innovative, high-risk interventions such as gene therapy, as well as new delivery systems based on molecular insights.

View my most recent publications at PubMed

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Neurology Associates
15 Parkman Street
Boston MA, 02114-3117
Phone: 617-726-6093
Neurology Associates
55 Fruit Street
Boston MA, 02114-2696
Phone: 857-238-5600
Fax: 857-238-5601

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