Angela E. Lin, MD is a Board-certified pediatrician and clinical geneticist who has dedicated her career to the care of people with physical differences, especially congenital heart defects (CHDs) and syndromes. She has written almost 100 articles and chapters. Dr. Lin attended St. Joseph's University and Thomas Jefferson Medical College in Philadelphia, and completed a pediatric residency at Children's Hospital of Pittsburgh. After fellowship in pediatric cardiology at UCLA, and additional training at the Children's Hospital of Philadelphia, she completed a genetics fellowship at the West Penn Hospital in Pittsburgh. From 1990-1994, she worked at the National Birth Defects Center in Boston. After a maternity leave, she joined the Massachusetts General Hospital in 1997, where she is a Staff Geneticist, and a Clinical Professor in Pediatrics at Harvard Medical School.
In 2011, she and Dr. Lynne Levitsky launched the multi-disciplinary Turner Syndrome Clinic. She has been a member of the Medical Advisory Board of the Turner Syndrome Society of the United States for almost 10 years. She co-founded the MGH HHT Center in 2010, and has developed a cardiogenetics service. Dr. Lin is the former Co-Director of the Professional Advisory Committee of the Costello Syndrome Family Network, and sees patients with "rasopathy" syndromes.
Dr. Lin also works in birth defects surveillance, part of completed National Birth Defects Prevention Study and the new BD Steps program, at the MA Dept. of Public Health. She studies the prevalence of CHDs. She is also an Associate Editor of the American Journal of Medical Genetics.
ResearchDr. Lin is a medical geneticist clinical researcher who has delineated clinical and molecular aspects of several malformation syndromes in major reviews (CHARGE, BOFS, Sensenbrenner, MMF embryopathy), as well as contributing cases to define the molecular basis of new syndromes (Myhre syndrome, macrocephly-capillary malformation, auriculo-condylar syndrome, deletion 2q23.1). Her greatest interest has been studying the pattern and frequency of cardiac abnormalities, especially Costello syndrome (and other rasopathy syndromes) and Turner syndrome.
Dr. Lin is a frequent participant in research about birth defects, especially those which are identified through newborn surveillance. These projects have been conducted at the Brigham-Women's Malformation Surveillance Program, and as a consultant to the Massachusetts Center for Birth Defects Prevention. As part of the National Birth Defecs Prevention Study (1997-2013), Dr. Lin has focused on congenital heart defects (CHDs), especially heterotaxy. She is a frequent collaborator in projects studying risk factors for CHDs, classification of CHDs, and currently, is contributing to the analysis of critical CHDs, and CHD prevalence in adults.
Lin AE, et al. 1986. Aortic root dilatation, dissection, and rupture in patients with Turner syndrome. J Peds 109:820-8.
Lin AE,et al. and the NNFFInternational Database Participants. Cardiac anomalies in neurofibromatosis, type 1 (NF1). Am J Med Genet 2000;95:108-117.
Lin AE, et al. 2011. An additional patient with mycophenolate mofetil embryopathy: cardiacand facial analyses. Am J Med Genet PartA 155:748-756.
Lin AE, et al. 2011. Clinical, pathological and molecular analyses of cardiovascular abnormalities in Costello syndrome: A Ras/MAPK pathway syndrome. AJMG 155:486-507.
LinAE, et al. 2013. Sensenbrenner syndrome(Cranioectodermal Dysplasia): Clinical and molecular analyses of 39 patientsincluding two new patients. Am J Med Genet Part A 161A:2762?2776.
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