Massachusetts General Hospital

BiographyW. Taylor Kimberly, MD PhD is a critical care neurologist in the Department of Neurology. He serves as the Associate Director of the MGH Neuroscience Intensive Care Unit and is an Assistant Professor of Neurology at Harvard Medical School. Dr. Kimberly's research group is located in the Center for Human Genetic Research, and studies blood-based and neuroimaging biomarkers of acute brain injury and cerebral edema. Through the use of metabolomics and neuroimaging, the goal is to identify novel therapeutic targets for stroke. He cares for patients in the Intensive Care Unit, the Emergency Department, and the outpatient setting.

Publications

View my most recent publications at PubMed

(Selected)

Wolfe MS et al. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and g-secretase activity. Nature, 398:513-517 (1999).

Kimberly WT et al. g-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1 and pen-2. Proc. Natl. Acad. Sci. U.S.A., 100:6382-6387 (2003).

Singhal AS et al. Case Records of the Massachusetts General Hospital. A 36-year-old woman with headache, hypertension, and seizure 2 weeks post-partum. New Engl. J. Med., 360:1126-1137 (2009).

Kimberly WT et al. Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy. Neurology, 72:1230-1235 (2009).

Kimberly WT et al. Lower hemoglobin correlates with larger stroke volumes in acute ischemic stroke. Cerebrovasc. Dis. Extra, 1:44-53 (2011).

O'Connor SG et al. Process improvement methods increase the efficiency, accuracy and utility of a neurocritical care research repository. Neurocrit. Care, 17:90-96 (2012).

Kimberly et al. Sex differences and hemoglobin levels in relation to stroke outcomes. Neurology, 80: in press (2013).

Mass General Critical Care Center investigators enjoy first research retreat

Massachusetts General Hospital investigators collaborate with clinical staff to generate new knowledge and discuss innovations at the First Annual Critical Care Research Retreat.