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Hyman Lab

The Hyman lab focuses on research in neural system failure underlying cognitive loss in Alzheimer’s disease.

Overview

Dr. Hyman directs the Alzheimer’s disease research unit at the MassGeneral Institute for Neurodegenerative Disease with the goal of understanding the neuropathophysiologic and genetic factors that underlie dementia. His laboratory studies the anatomical and molecular basis of dementia in Alzheimer’s disease, and dementia with Lewy bodies.

Dr. Hyman’s research includes a collaborative of several labs working on different aspects of neurodegenerative disease and dementia. The following principal investigators have research labs and collaborate with Dr. Hyman’s lab.

Brad Hyman seated in front of a microscope

Principal Investigator

Bradley T. Hyman, MD, PhD

  • John B. Penney, Jr. Professor of Neurology 
    Harvard Medical School
  • Associate in Neurology,
    Massachusetts General Hospital
  • Director,
    Massachusetts Alzheimer's Disease Research Center

Affiliated Principal Investigators

Laboratory Staff - includes all lab members of principal investigator labs

  • Arbel, Michal, PhD
  • Arimon, Muriel, PhD
  • Barroeta-Espar, Isabel, MD
  • Cagsal-Getkin, Ozge
  • Cao, Luxiang, PhD
  • Costantino, Isabel
  • Dashkoff, Jonathan, MD/PhD
  • Fan, Zhanyun
  • Galea, Elena, PhD Sabbatical from Spain
  • Hawkes, Jonathan
  • Herskovits, Zara, MD, PhD
  • Hori, Yukiko, PhD
  • Hou, Steven ()
  • Hudry, Eloise, PhD
  • Kastanenka, Ksenia, PhD
  • Kuzuya, Akira, MD, PhD
  • Laffey, Gala Guerard
  • Lee, Allyson
  • Liu, Andy
  • Marquie-Sayagues, Marta, MD
  • Neville, Kevin
  • Nicholls, Samantha, PhD
  • Patel, Nehal
  • Perez-Nievas Gomez, Beatriz, PhD
  • Polydoro, Manuela, PhD
  • Pooler, Amy, PhD
  • Rice, Wendy
  • Rodriguez, Steven, PhD
  • Rudinskiy, Nikita, PhD
  • Saqran, Lubna,
  • Shakerdge, Naomi 
  • Takeda, Shuko, MD, PhD
  • Vanderburg, Chuck, PhD
  • Wang, Xueying
  • Wegmann, Susanne, PhD
  • William, Chris, MD, PhD

Updated 9/12/2013

Read about and apply for residency, fellowship and observership programs at http://www.massgeneral.org/neurology/education/.

Apply for temporary positions (summer interns) through the Bulfinch Temporary Service Web site at http://www.massgeneral.org/careers/temporary.aspx. Search for all opportunities using ID# 2200484.

All applicants should register with the Mass General Careers Web site at http://www.massgeneral.org/careers/viewall.aspx. Request a list of current open positions at mghneurologyjobs@partners.org.

Tau Pathology Spreading out from the Entorhinal Cortex Can be Reversed

Neurofibrillary tangles - largely composed of tau protein- are one of the two pathological hallmarks of Alzheimer’s disease.

View All PubMed Publications

  1. Hyman BT, Yuan J. Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nat Rev Neurosci. 2012; 13(6):395-406. View in: PubMed
  2. Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012 May; 71(5):362-81. View in: PubMed
  3. Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct Dendritic Spine and Nuclear Phases of Calcineurin Activation after Exposure to Amyloid-ß Revealed by a Novel Fluorescence Resonance Energy Transfer Assay. J Neurosci. 2012 Apr 11; 32(15):5298-309. View in: PubMed
  4. Pankratz N, Beecham GW, Destefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T. Meta-analysis of Parkinson's Disease: Identification of a novel locus, RIT2. Ann Neurol. 2012 Mar; 71(3):370-84. View in: PubMed
  5. Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid Beta neurotoxicity in a mouse model of Alzheimer's disease. J Neurosci. 2012 Feb 29; 32(9):3176-92. View in: PubMed

MassGeneral Institute for Neurodegenerative Disease

Building 114, Charlestown Navy Yard
Mailcode: CNY B114-2-2003
114 16th Street, Room 2003
Charlestown, MA 02129

Phone: 617-726-2000
Fax: 617-724-1480

Public Transportation Access: yes
Disabled Access: yes

How to Apply for Positions

How to apply for jobs: Send an e-mail to mghneurologyjobs@partners.org to receive an automated e-mail with full instructions for all types of positions.

Fundraising Contact

Contact Shawn Fitzgibbons in the Mass General Development office at 617-643-0447 or sfitzgibbons@partners.org.

Administration

Anne B. Young, MD, PhD
Director, Massgeneral Institute for Neurodegenerative Disease 
Professor of Neurology, Harvard Medical School

Directions to MIND Research labs (PDF)

Clinical Appointments, Consultations & Clinical Trials

Please visit the main Neurology Service Contact page for all other contact information.