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News, publications and events from the Department of Surgery at Massachusetts General Hospital.
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An international research team led by a Massachusetts General Hospital investigator has developed the largest database of protein-to-protein interaction networks, a resource that can illuminate how numerous disease-associated genes contribute to disease development and progression.
A team of Massachusetts General Hospital investigators has found a possible mechanism explaining why use of the sugar substitute aspartame might not promote weight loss.
A study from Massachusetts General Hospital investigators has identified a mechanism leading to tolerance of a common, difficult-to-treat bacteria by means of small molecule usually used by the pathogen to monitor its presence in the environment.
A study led by Massachusetts General Hospital investigators reveals how spontaneous changes in the molecular characteristics of tumors can lead to tumors with a mixed population of cells requiring treatment with several types of therapeutic drugs.
A Massachusetts General Hospital research team has reported that repeated treatment with pulsed electric fields – a noninvasive procedure that does not generate heat – may help reduce the development of scarring.
A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine have created a "liver on a chip," a model of liver tissue that replicates the metabolic variations found throughout the organ and more accurately reflects the distinctive patterns of liver damage caused by exposure to toxins.
A team of surgeons at Massachusetts General Hospital announced today that they have performed the nation's first genitourinary reconstructive (penile) transplant.
Massachusetts General Hospital investigators have found that circulating tumor cell (CTC) clusters – which are more efficient in spreading cancer throughout the body than are single CTCs – can pass through capillary-sized blood vessels. Their findings suggest potential strategies to reduce clusters’ metastatic potential
Physicians in the Fireman Vascular Center at Massachusetts General Hospital (MGH) are now offering a new and less invasive method of treatment for carotid artery disease known as transcarotid artery revascularization, or TCAR.
MGH researchers have taken initial steps toward the creation of bioengineered human hearts using donor hearts stripped of components that would generate an immune response and cardiac muscle cells generated from induced pluripotent stem cells, which could come from a potential recipient.
A team of MGH investigators has made the first steps towards development of bioartificial replacement limbs suitable for transplantation.
The latest version of a microfluidic device for capturing rare circulating tumor cells is the first designed specifically to capture clusters of two or more cells, rather than single cells. Recent studies by MGH investigators and others have suggested that CTC clusters are significantly more likely to cause metastases than single circulating tumor cells.
A team led by MGH investigators has identified a set of characteristics – including differences in gene expression – that may indicate which patients recovering from severe burns are at greatest risk for repeat infections. Predicting the risk of infection before it occurs would indicate which patients should receive preventive treatment and reduce the unnecessary use of antibiotics in those at low risk.
A team of MGH investigators has identified what may be a biomarker predicting the development of the dangerous systemic infection sepsis in patients with serious burns.
The first long-term study of a pioneering endoscopic laser treatment for early vocal-cord cancer, developed at MGH and previously shown to provide optimal voice outcomes, finds that it is as successful as traditional approaches in curing patients’ tumors while avoiding the damage to vocal quality caused by conventional treatments.
A microfluidic device developed at Massachusetts General Hospital may help study the epithelial-mesenchymal transition, a fundamental change in cellular characteristics that has been associated with the ability of tumor cells to migrate and invade other sites.
An immune-regulating cell present in lymph nodes may be able to halt severe cases of sepsis, an out-of-control inflammatory response that can lead to organ failure and death.
A revised version of a surgical procedure to treat severe chronic migraine headaches led to significant symptom relief more than 90 percent of the time in a group of patients treated at Massachusetts General Hospital.
Circulating tumor cells captured with a microchip-based device developed at the MGH Center for Engineering in Medicine and the MGH Cancer Center can be cultured to establish cell lines that accurately reflect a tumor’s genetic mutation over time and changing susceptibility to therapeutic drugs.
Two international research studies, both led by investigators affiliated with MGH and the Broad Institute, have uncovered new information about genes that may increase the risk of serious cardiac arrhythmias.
A system developed by investigators at the Massachusetts General Hospital Center for Engineering in Medicine allowed successful transplantation of rat livers after preservation for as long as four days, more than tripling the length of time organs currently can be preserved.
A specially-bred strain of miniature swine lacking the molecule responsible for the rapid rejection of pig-to-primate organ transplants may provide a new source of skin grafts to treat seriously burned patients.
Application of a technology currently used to disinfect food products may help to get around one of the most challenging problems in medicine today, the proliferation of bacteria resistant to antibiotics and other antimicrobial drugs.
MGH investigators have identified the mechanism by which an enzyme produced in the intestinal lining helps to maintain a healthy population of gastrointestinal microbes.
A system developed by investigators at the MGH Center for Engineering in Medicine and the MGH Transplant Center has the potential to increase both the supply and the quality of donor organs for liver transplantation.
Making an important step towards greater availability of hand and face transplants, MGH investigators have shown that a procedure developed to induce immune tolerance to organ transplants can induce tolerance to a model limb transplant in miniature swine.
Massachusetts General Hospital offers pulmonary thromboendarterectomy (PTE), a highly specialized operation to remove chronic blood clots in the lungs. Without surgery, patients who have this life-threatening disease will likely develop progressive shortness of breath so severe that it leads to heart failure.
A device that measures the movement of key immune cells, developed by MGH investigators, may help determine which patients with serious burns are at risk for septic complications, and a novel treatment that directly addresses the cause of those complications could prevent many associated deaths.
Feeding an intestinal enzyme to mice kept on a high-fat diet appears to prevent the development of metabolic syndrome – a group of symptoms associated with type 2 diabetes, cardiovascular disease and fatty liver – and to reduce symptoms in mice that already had the condition.
A new system for isolating rare circulating tumor cells – living solid tumor cells found at low levels in the bloodstream – shows significant improvement over previously developed devices and does not require prior identification of tumor-specific target molecules.
The elevated risk of melanoma among people with red hair and fair skin may be caused by more than just a lack of natural protection against ultraviolet radiation. Resarchers at the MGH Cutaneous Biology Research Center and Cancer Center have found that the type of skin pigment predominantly found in red-haired, fair-skinned individuals may itself contribute to the development of melanoma.
Massachusetts General Hospital has moved into the number one spot on the 2012-13 U.S. News & World Report’s “America’s Best Hospitals” list.
New research by a team from the Broad Institute, Dana-Farber Cancer Institute, and Massachusetts General Hospital suggests that how cancer evade drug treatment may depend on the interplay between tumor cells and their healthy counterparts.
MGH surgeons have developed a new technique for reconstructing the larynx after surgery for advanced cancer. The approach uses cryopreserved aortas from deceased donors to replace removed larynx tissue and allows some patients to avoid a permanent tracheotomy and maintain voice and swallowing function.
MGH investigators have developed a novel strategy to protect the liver from drug-induced injury and improve associated drug safety. The team reports that inhibition of a type of cell-to-cell communication can protect against the damage caused by liver-toxic drugs such as acetaminophen.
Serious traumatic injuries, including major burns, set off a "genomic storm" in human immune cells, altering around 80 percent of the cells' normal gene expression patterns.
Combined targeted therapy against the BRAF/MAPK pathway with immunotherapy shows promise as a new therapeutic approach for the treatment of melanoma, according to results of a preclinical study by MGH researchers.
Technical improvements to a microchip-based device for detecting and analyzing tumor cells in the bloodstream are revealing cellular differences that may reflect a tumor's aggressiveness and long-term response to treatment.
A report from a team of Massachusetts General Hospital physicians calls into question the longstanding belief that pulmonary embolism – the life-threatening blockage of a major blood vessel in the lungs – is caused in trauma patients by a blood clot traveling from vessels deep within the legs or lower torso.
A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine has found the first evidence of cell-to-cell communication by amino acids, the building blocks of proteins, rather than by known protein signaling agents such as growth factors or cytokines.
A group of hospitals in eight cities around the globe has successfully demonstrated that the use of a simple surgical checklist during major operations can lower the incidence of deaths and complications by more than one third.
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David Rattner, MD, Co-Chief of the Massachusetts General Hospital Digestive Healthcare Center describes how chronic heartburn can lead to other serious conditions, who is most at risk and how Barrett's esophagus and esophageal cancer can be diagnosed and treated.
Michael Jaff, DO, Medical Director of the Massachusetts General Hospital Fireman Vascular Center explains how carotid artery disease can cause a stroke, unless it is found early and treated, and how you can identify your risk for this condition.
Alice Shaw, MD, thoracic oncologist at the Mass General Cancer Center, says patients with lung cancer can benefit from genetic testing, particularly if they are young non-smokers. Learn more about personalized treatment for lung cancer and new "smart drugs" that target a tumor's specific genetic mutation to slow the cancer's growth, and in some cases, reduce it significantly.
Watch 46-year-old Frank Robinson tell the story of his life-saving experience at Mass General after a massive coronary.
Since 1811, people have counted on Mass General for answers, innovations and medical leadership. As our third century dawns, we remain ready to serve.
Dr. Richard Cambria, chief of vascular surgery at Mass General, says family history can provide clues.
The Ferguson-Ottinger Endowed Fund for Surgical Residents supports a visiting professorship, educational and networking opportunities for surgical residents at Massachusetts General Hospital.
W.G. (Jay) Austen Jr., MD, Chief of Plastic and Reconstructive Surgery at Massachusetts General Hospital, discusses a cutting edge procedure done at Mass General: Plastic Surgery for Migraines.
Diagnosed with idiopathic pulmonary fibrosis, Thomas Derigo, a husband and father to two teenage girls, had only one option: lung transplantation. Under the expert care of his team at Mass General, Thomas’s transplantation was a success, giving him the ability to live life normally and do the things he loves the most.
An ultrasound at 19 weeks showed that Andrew Johnson would be born with kidney functionality complications. Fortunately for Andrew, his mother was a compatible donor, and when he was strong enough, Andrew underwent kidney transplantation at MassGeneral Hospital for Children Transplant Center. “Everyone was so nervous that day,” Tara Johnson states. “I was elated.”
Thor Sundt, MD, chief of cardiac surgery and director of the Corrigan Minehan Heart Center, talks about heart valve options for patients undergoing heart valve surgery.
Jonathan Passeri, MD, co-director of the Mass General Heart Valve Program and director of Interventional Echocardiography, talks about aortic valve stenosis and answers common questions about symptoms to look out for and treatment options.
For two years, Amy DeStefano struggled with increasing heart complications, leaving her needing a heart transplantation. Through one of Mass General’s clinical trials, Amy became the first person in New England to receive a "heart in a box" transplant. The device circulates blood through the donated heart, keeping it beating and giving doctors more time to perform a transplant.
LINX® Reflux Management System is an innovative minimally invasive procedure used by Massachusetts General Hospital surgeons to treat appropriately selected patients experiencing symptoms of gastroesophageal reflux disease (GERD). For more information, visit massgeneral.org/LINX
Per oral endoscopic myotomy (POEM) is a minimally invasive procedure used by surgeons at Massachusetts General Hospital to treat eligible patients experiencing symptoms of achalasia. For more information, visit massgeneral.org/POEM
Minimally invasive esophagectomy (MIE) is a procedure performed by Massachusetts General Hospital surgeons using small incisions to remove a diseased esophagus and reconstruct the gastrointestinal tract. For more information, visit massgeneral.org/MIE
Sareh Parangi, MD, endocrine surgeon in the Thyroid Nodule Program at Massachusetts General Hospital, discusses thyroid nodule biopsy results and treatment recommendations.
Roy Phitayakorn, MD, endocrine surgeon, and Giuseppe Barbesino, MD, endocrinologist, of the Thyroid Nodule Program at Massachusetts General Hospital discuss outcomes and ongoing care after thyroid surgery.
Dolly Lakkis—a business owner, optician and competitive dancer—didn’t have time to be sick. When mitral valve disease started to affect the quality of her life, she turned to a team of specialists at the Corrigan Minehan Heart Center at Massachusetts General Hospital. Dolly’s doctors were able to repair her damaged heart valve with minimally invasive surgery that got her back on her feet—and back on the dance floor—as quickly as possible.
Patients share their photos before and after Hair Restoration Surgery at Massachusetts General Hospital
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