About Steven Isakoff, MD, PhD, MMSC

Departments, Centers, & Programs:

Clinical Interests:

Treats:

Locations

Mass General Cancer Center: Hematology Oncology
55 Fruit St.
Boston, MA 02114
Phone: 617-726-6500
Fax: 617-724-1079

Medical Education

  • MD, New York University School of Medicine
  • Residency, Brigham and Women's Hospital
  • Fellowship, Dana Farber Cancer Institute

American Board Certifications

  • Medical Oncology, American Board of Internal Medicine

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Publications

  • Isakoff SJ, Tabernero J, et al. Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors. Ann Oncol. 2020 May Xu J,..., Isakoff SJ. A Phase II Trial of Cabozantinib in Hormone Receptor-Positive Breast Cancer with Bone Metastases. Oncologist. 2020 AugKoh SB, Ross K, Isakoff SJ, ... Ellisen LW. RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer. Clin Cancer Res. 2021 Sep 1Dent R, Oliveira M, Isakoff SJ, et al; LOTUS investigators. Final results of the double-blind placebo-controlled randomized phase 2 LOTUS trial of first-line ipatasertib plus paclitaxel for inoperable locally advanced/metastatic triple-negative breast cancer. Breast Cancer Res Treat. 2021 Sep Coates JT, Sun S, ... Isakoff SJ,...Ellisen LW. Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer. Cancer Discov. 2021 Aug 17.Xu J,...Isakoff SJ. Phase II trial of veliparib and temozolomide in metastatic breast cancer patients with and without BRCA1/2 mutations. Breast Cancer Res Treat. 2021 Aug 20.

Reviews: Comments and Ratings

4.9out of 5(172 Ratings, 77 Comments)

June 2025

Excellent


June 2025

Great Provide.


June 2025

Dr Isakoff is a caring, knowledgeable, and dedicated Doctor, we are all so lucky to have him.


June 2025

Dr Isakoff is always very kind and caring. He listens to my concerns and answers my questions thoroughly. He is always up on the latest breast cancer research/news and we discuss this. I feel lucky to have him as my doctor. Also, there is a wonderful person at the front desk. I don't have her name, but by way of a description, she has a skin ... Read More


June 2025

This doctor saved my life 10 years ago and I will always trust him and be grateful


June 2025

Thank you . I have been treat very well since I had breast cancer in [redacted]. Thank you to my oncologist , to the nurses and the doctor that did the operation . She did awesome job . I am very very thankful .


June 2025

Dr. Isakoff is a wonderful provider, I am very fortunate to have him on my care team. He a kind, personable, professional and extremely knowledgeable. He cares about his patients.


June 2025

Great care and hopefully next visit my blood will be checked .


May 2025

Yes, Dr. Isakoff is very knowledgeable, caring, gives you plenty of time, asks, you know, lets you ask lots of questions, shares lots of information. He's fantastic. I would recommend him highly. Thank you.


May 2025

I always feel cared for by Dr Isakoff

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