Learn more about OASIIS


members of the OASIIS Lab
(L-to-R) Nathan Miner, Chris Bono, MD, Caleb Myers, Maria Chiu, and Theresa Chua

The Orthopaedic Augmentation, Surgical Innovation, and Interactive Systems Lab (OASIIS), is is a research team of doctorate and post-doctorate students led by orthopaedic surgeons Daniel Tobert, MD, and Christopher Bono, MD, in collaboration with Northeastern University Professor Casper Harteveld, PhD. OASIIS is dedicated to innovating orthopedic care using advanced analytical technologies such as artificial intelligence, wearable sensors and interactive media to optimize outcomes assessment. This collaboration is powered by combined expertise in musculoskeletal disorders, data science, engineering and immersive media.

Research Projects & Topics

Dr. Tobert and Alireza Gholipour, PhD oversee multiple projects using a comprehensive database assembled for the Mass General Brigham orthopaedic registry. The team has harnessed the registry database to develop individual dashboards that allow a surgeon to assess and address their own surgical outcomes in real-time. The team is also using the database to better define clinical improvement, stratify risk, and inform patient selection.

Dr. Bono, Nathan Miner, Maria Chiu and Casper Harteveld, PhD, are assessing patient outcomes using interactive media and virtual reality. The team has developed standardized, immersive activities for patients during which their performance is assessed. In this, they are using gaming technology to develop a "game changer" in the collection of musculoskeletal outcomes data.


Recent Publications
  • Karhade AV, Bernstein DN, Desai V, Bedair HS, O'Donnell EA, Tanaka MJ, Bono CM, Harris MB, Schwab JH, Tobert DG. What Is the Clinical Benefit of Common Orthopaedic Procedures as Assessed by the PROMIS Versus Other Validated Outcomes Tools? Clin Orthop Relat Res. 2022 Sep 1;480(9):1672-1681. doi: 10.1097/CORR.0000000000002241. Epub 2022 May 10. PMID: 35543521; PMCID: PMC9384920.
  • Karhade AV, Bono CM, Schwab JH, Tobert DG. Minimum Clinically Important Difference: A Metric That Matters in the Age of Patient-Reported Outcomes. J Bone Joint Surg Am. 2021 Dec 15;103(24):2331-2337. doi: 10.2106/JBJS.21.00773 . PMID: 34665785.
  • Koole D, Lans A, Lang JH, de Groot TM, Borkhetaria P, Verlaan JJ, Schwab JH, Tobert DG. Limited health literacy results in lower health-related quality of life in spine patients. Spine J. 2023 Sep 27;S1529-9430(23)03411. PMID: 37774984. https://doi.org/10.1016/j.spinee.2023.09.016. Epub 2023 Sep 27
  • Bernstein DN, Karhade AV, Bono CM, Schwab JH, Harris MB, Tobert DG. Sociodemographic Factors Are Associated with Patient-Reported Outcome Measure Completion in Orthopaedic Surgery: An Analysis of Completion Rates and Determinants Among New Patients. JB JS Open Access. 2022;7(3):e22.00026. PMID: 35935603. PMCID: PMC9355105. https://doi.org/10.2106/JBJS.OA.22.00026. Epub 2022 Aug 04.
  • Miner, N., Myers, C., Shirodkar, V., Wang, Z., Zhang, Q., & Harteveld, C. (2022, October). Magic Mirror on the Wall: Reflecting the Realities of Lower Limb Rehabilitation in Virtual Reality. In 2022 IEEE International Symposium on Mixed and Augmented Reality Adjunct (ISMAR-Adjunct) (pp. 576-581). IEEE.

Our Team

Principal Investigators

Affiliated Faculty

  • Casper Harteveld, PhD (Associate Dean, College of Art, Media and Design, Northeastern University)

Doctoral and Post-Doctoral Researchers

  • Alireza Gholipour, PhD
  • Nathan Miner
  • Maria Chiu

Research and Development Team

  • Caleb Myers

Former Team Members

  • Theresa Chua
  • Andreea Renata Lucaciu