Guillermo J. Tearney, MD, PhD
Professor of Pathology, Harvard Medical School
Remondi Family Foundation Endowed MGHRI Chair
Pathologist, Massachusetts General Hospital
Physicist, Massachusetts General Hospital
Faculty, Wellman Center for Photomedicine
Massachusetts General Hospital
Bar 703 and BHX604A
Wellman Center for Photomedicine
Boston, MA 02114
Explore This Lab
Dr. Tearney’s research interests are focused on the development and clinical validation of non-invasive, high-resolution optical imaging methods for disease diagnosis. Dr. Tearney’s lab was the first to perform human imaging in the coronary arteries and gastrointestinal tract in vivo with Optical Coherence Tomography (OCT), which provides cross-sectional images of tissue architectural microstructure at a resolution of 10 mm. He has also conducted many of the seminal studies validating OCT and is considered an expert on OCT image interpretation. Recently, Dr. Tearney’s lab has invented a next generation OCT technology, termed mOCT, which has a resolution of 1 mm and is capable of imaging cells and sub cellular structures in the coronary wall. Dr. Tearney has also developed several other technologies, including a confocal endomicroscope capable of imaging the entire esophagus, a capsule that once swallowed captures three-dimensional microscopic images of the GI tract, an ultraminiature three-dimensional endoscope, a highly efficient form of near field scanning optical microscopy (NSOM), and novel fluorescence spectroscopy and multimodality imaging techniques. He has an active program in Raman spectroscopy and has conducted the first intracoronary Raman in vivo. Dr. Tearney is co-editor of The Handbook of Optical Coherence Tomography and has written over 250 peer-reviewed publications.
Dr. Tearney’s work extends beyond his laboratory at MGH. Many of his technologies are being produced commercially; he is the vice-chair of CAP’s in vivo microscope committee and he has founded the International Working Group on Intravascular OCT Standardization and Validation, a group that is dedicated to establishing standards to ensure the widespread adoption of this imaging technology.
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Yin B, Hyun C, Gardecki JA, Tearney GJ. Extended depth of focus for coherence- based cellular imaging. Optica. 2017; 4:959-965.
Ughi GJ, Wang H, Gerbaud E, Gardecki JA, Fard AM, Hamidi E, Vacas-Jacques P, Rosenberg M, Jaffer FA, Tearney GJ. Clinical characterization of coronary atherosclerosis with dual-modality OCT and near-infrared autofluorescence imaging. JACC Cardiovasc Imaging. 2016; 9(11):1304-14.
Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure. Gora MJ, Sauk JS, Carruth RW, Gallagher KA, Suter MJ, Nishioka NS, Kava LE, Rosenberg M, Bouma BE, Tearney GJ. Nat Med. 2013 Feb;19(2):238-40.
Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo. Yoo H, Kim JW, Shishkov M, Namati E, Morse T, Shubochkin R, McCarthy JR, Ntziachristos V, Bouma BE, Jaffer FA, Tearney GJ. Nat Med. 2011 Nov 6;17(12):1680-4.