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Dr. Vibha Singhal is a board certified Pediatric Endocrinologist with a particular interest in obesity medicine. She has a grant from the NIH which evaluates the effects of sleeve gastrectomy on insulin secretion and the factors that determine that change in adolescents with severe obesity. Her career goal is to develop personalized medicine to prevent and manage obesity and improve outcomes.
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MassGeneral Hospital for Children
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I attended medical school at All India Institute of Medical Sciences (AIIMS), the top medical school in India. While at AIIMS I gained a great deal of clinical experience and afterwards decided to continue my training in the United States. After some early laboratory experience, I started my residency training at the Mayo Clinic, in Rochester, Minnesota. While at the Mayo Clinic, I had the pleasure of learning and practicing clinical pediatrics in a state of the art medical center. I was able to pursue research through infrastructure and resources that had previously been unavailable to me and my training and research during this time solidified my passion for research in pediatric obesity.
I subsequently joined the fellowship program at The Massachusetts General Hospital which provided a sound base of clinical knowledge. Here I continue to practice and learn from the world's leading providers and researchers. My own research focuses on evaluating regional fat depots. I am interested in associations between visceral, subcutaneous, marrow and brown fat and how changes to these fat depots relates to bone accrual. I have presented my research at national and international meetings. I recently received federal funding to evaluate the changes in function of the pancreas after weight loss surgery (particularly sleeve gastrectomy) in adolescents. My long term goal is to develop personalized therapies for extreme obesity in adolescents.
My research interests include evaluation of bone outcomes in extremes of spectrums – anorexia nervosa to severe obesity. I am also interested in evaluating the role of different fat depots – visceral, subcutaneous, marrow and brown fat and their contribution to bone and metabolic consequences in various disease states like athletic triad and anorexia. My recent work focuses on evaluating metabolic changes that happen after bariatric surgery in adolescents and the potential mechanisms contributing to those changes.
Metabolic outcomes of bariatric surgery in adolescents
Ongoing: Beta-cell function after sleeve gastrectomy
Bone metabolism, neuroendocrine alterations and regional fat alterations in nutritional disorders including obesity, anorexia nervosa, and athletic amenorrhea.
Ongoing: Marrow fat changes in girls with anorexia nervosa and evaluating changes after estrogen and IGF-1 replacement
Learn more about research at the Pediatric Endocrine Program and Diabetes Center.
View my most recent publications at PubMed
Listed only a few out of 14 first author and co-authored publications
Two physician scientists from MassGeneral Hospital for Children (MGHfC) have received pilot feasibility grants to conduct innovative preliminary research in the fields of pediatric gastroenterology, endocrinology and behavioral health.
This year, MassGeneral Hospital for Children (MGHfC) celebrated its 10th annual Research Day, an event that recognizes the pioneering research of investigators throughout the hospital whose discoveries help to better understand childhood health and disease.
The outlook for child health research – both in federal funding and at the MassGeneral Hospital for Children (MGHfC) – is a bright one, was the message from speakers at the 10th anniversary of MGHfC Pediatric Research Day.
Ether Day, a tradition started in 1945, is a day to recognize MGHfC and Mass General staff for their years of service to patients and the hospital's overall mission. Learn more about what MGHfC means to some of those providers and staff.
Perseverance and grace are qualities people often learn through life experiences. For 17-year-old Olivia Renzi, these qualities allowed her to transform stumbling blocks into stepping stones.
For years, doctors could not determine why Olivia Renzi, 17, was growing so rapidly. She was much taller than other children her age and wasn’t developing normally. In 2013, her mother knew something wasn’t right, so she brought her then 14-year-old daughter to MGHfC. Olivia was diagnosed with gigantism, a rare growth disorder, but the diagnosis taught her to tap into a source of inner strength she didn't know she had.
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