Medications in Pregnancy
It is difficult to advise a woman about the safety of medications in pregnancy since there might be long-term drug effects of which we are unaware. Each woman has to weigh the benefits versus the risks.
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With the correct care, most women can enjoy a healthy pregnancy--even with health challenges such as diabetes, high blood pressure, infectious diseases, or sextually transmitted infections. Read on to learn more.
Corrigan Minehan Heart Center
The Elizabeth Anne and Karen Barlow Corrigan Women's Heart Health Program at the Massachusetts General Hospital Corrigan Minehan Heart Center is a leading program for the cardiac care of women of all ages.
The Diabetes in Pregnancy Program at Massachusetts General Hospital provides integrated obstetric and endocrine care for pregnant women with all types of diabetes.
The HOPE Clinic (Harnessing support for Opioid and substance use disorders in Pregnancy and Early childhood) provides care for pregnant women with substance use disorder and their infants from conception through early childhood.
The Obstetrics Program at Massachusetts General Hospital provides state-of-the-art, individualized care for women before, during and after childbirth.
The Placenta Accreta and Advanced Obstetric Surgical Program at Massachusetts General Hospital provides specialized care for women anticipating a surgical delivery, including those with placenta accreta and related placental complications.
The Ultrasound and Prenatal Diagnostics Center at Mass General offers state-of-the-art ultrasound and prenatal diagnostic testing and care.
Certain health conditions may complicate a pregnancy. But with the correct care, most women can enjoy a healthy pregnancy, even with their health challenges.
Diabetes is a health problem where the body doesn't make enough insulin. Or the body is not able to use the insulin that is made. Insulin is the hormone that lets glucose enter the cells of the body to make fuel. When glucose can't enter the cells, it builds up in the blood, and the body's cells starve to death. Diabetes in pregnancy can have serious results for you and your growing baby. How serious the problems are depends on how serious your diabetes is. This is especially true if you have blood vessel (vascular) problems and your blood sugar (glucose) is not in good control.
When diabetes happens during pregnancy, it is described as:
Gestational diabetes. This is when you develop a resistance to insulin because of the hormones of pregnancy. If you develop gestational diabetes, you may be noninsulin dependent or insulin dependent.
Pregestational diabetes. This is when you already have diabetes and become pregnant.
Gestational diabetes is a condition that occurs during pregnancy in women who haven't been diagnosed with diabetes before. During pregnancy, these women have a high (elevated) glucose level and other diabetic symptoms. In most cases, all diabetic symptoms go away after delivery. But women with gestational diabetes have an increased risk of developing diabetes later in life. This is especially true if they were overweight before pregnancy.
Unlike other types of diabetes, gestational diabetes is not caused by a lack of insulin. It's caused by other hormones that block the insulin that is made. This is called insulin resistance.
The cause of gestational diabetes isn't known. But there are some theories as to why it happens.
The placenta supplies a growing baby with nutrients and water. It also makes a variety of hormones to maintain the pregnancy. Some of these hormones are estrogen, cortisol, and human placental lactogen. These hormones can block insulin. This often starts about 20 to 24 weeks into the pregnancy.
As the placenta grows, more of these hormones are made. Insulin resistance becomes greater. Normally, the pancreas is able to make more insulin to overcome insulin resistance. But when not enough insulin is made to overcome the effect of the placental hormones, gestational diabetes results.
Any woman may have gestational diabetes during pregnancy. But these factors may raise the risk:
Family history of diabetes
Having given birth before to a very large infant, a stillbirth, or a child with a birth defect
Age. Women who are older than 25 are at greater risk than younger women.
A higher level of glucose in the urine is often included in the list of risk factors. But it isn't believed to be a reliable sign for gestational diabetes.
A glucose screening test is often done between 24 and 28 weeks of pregnancy. For this test, you drink a special glucose beverage. Your blood sugar level is then measured 1 hour later.
If this test shows an increased blood sugar level, you may need a 3-hour glucose tolerance test after a few days of eating a special diet. If results of the second test are in the abnormal range, gestational diabetes is diagnosed.
Treatment will depend on your symptoms, age, and general health. It will also depend on how severe the condition is.
Treatment for gestational diabetes focuses on keeping blood glucose levels in the normal range. Treatment may include:
Daily blood glucose monitoring
Insulin injections or prescription medicines
Unlike other types of diabetes, gestational diabetes generally doesn't cause birth defects. Birth defects often show up during the first trimester of pregnancy. They are more likely in women with pregestational diabetes who may have changes in blood sugar during that time. Women with gestational diabetes generally have normal blood sugar levels during the critical first trimester.
The complications of gestational diabetes can often be managed and prevented. The key to prevention is to carefully control your blood sugar as soon as your healthcare provider diagnoses gestational diabetes.
Infants of mothers with gestational diabetes are at risk for several chemical imbalances. Examples are low levels of calcium and magnesium in the blood. But the main problems of gestational diabetes are the following.
This is when a baby is much larger than normal. All of the nutrients the baby gets come directly from the mother's blood. If the mother's blood has too much glucose, the baby's pancreas senses the high glucose levels and makes more insulin to try to use this glucose. The baby converts the extra glucose to fat. Even when the mother has gestational diabetes, the baby is able to make all the insulin it needs. The combination of high blood glucose levels from the mother and high insulin levels in the baby results in large deposits of fat. This causes the baby to grow very large.
Birth injury may occur because of the baby's large size and problems being born.
Hypoglycemia is when the baby has low blood sugar right after birth. This problem happens if the mother's blood sugar levels have been high. This causes the baby to have a high level of insulin in its circulation. After birth, the baby still has a high insulin level. But it no longer has the high level of sugar from its mother. This results in the newborn's blood sugar level becoming very low. The baby's blood sugar level is checked after birth. If the level is too low, the baby may need glucose given by IV (intravenously).
Too much insulin or too much glucose in a baby's system may delay lungs becoming fully mature. This can cause breathing problems. This is more likely if a baby is born before 37 weeks of pregnancy.
High blood pressure can happen in pregnancy in 2 forms. It may be a preexisting health problem called chronic hypertension. Or it can develop during pregnancy. It is then known as gestational hypertension. It is also called toxemia or preeclampsia. It happens most often in young women with a first pregnancy. It is more common in twin pregnancies, and in women who had blood pressure problems in an earlier pregnancy.
High blood pressure can lead to placental problems and slowed fetal growth. If untreated, severe high blood pressure may cause unsafe seizures and even death in the mother and developing baby.
Women with preeclampsia may need bedrest. If you have moderate or severe preeclampsia or eclampsia (preeclampsia complicated by seizures), you will often need to stay in the hospital and be treated with medicines.
Women who have high blood pressure before pregnancy often need to keep on taking their blood pressure medicine. Your healthcare provider may switch you to a safer medicine during pregnancy.
Kidney function tests and ultrasounds are often done more often on pregnant women with high blood pressure. They help keep an eye on the mother's health and the baby's growth and development.
Infections during pregnancy can pose a threat to the unborn baby. Even a simple urinary tract infection, which is common during pregnancy, should be treated right away. An infection that goes untreated can lead to preterm labor and rupture of the membranes surrounding the baby. Some infectious diseases are listed below.
Toxoplasmosis is an infection caused by a single-celled parasite named Toxoplasma gondii. Many people may have toxoplasma infection. But very few have symptoms because the immune system often keeps the parasite from causing illness. Babies who were infected before birth can be born with serious mental or physical problems. Toxoplasmosis often causes flu-like symptoms, swollen lymph glands, or muscle aches and pains that last for a few days to several weeks. You can be tested to see if you have developed an antibody to the illness. Fetal testing may include ultrasound or testing of amniotic fluid or cord blood. Treatment may include antibiotics. The following measures can help prevent toxoplasmosis infection:
Wear gloves when you garden or do anything outdoors that involves handling soil. Cats may pass the parasite in their feces. They often use gardens and sandboxes as litter boxes. Wash your hands well with soap and warm water after outdoor activities. Do this especially before you eat or prepare any food.
Have someone who is healthy and not pregnant change your cat's litter box. If this isn't possible, wear gloves and clean the litter box daily. The parasite found in cat feces can only infect you a few days after being passed. Wash your hands well with soap and warm water afterward.
Have someone who is healthy and not pregnant handle raw meat for you. If this isn't possible, wear clean, latex gloves when you touch raw meat. Wash any cutting boards, sinks, knives, and other utensils that might have touched the raw meat. Wash your hands well with soap and warm water afterward.
Cook all meat thoroughly. This means until it is no longer pink in the center or until the juices run clear. Don't taste meat before it is fully cooked.
A pregnant woman shouldn't eat undercooked or raw foods because of the risk of food poisoning. Food poisoning can dehydrate you and keep your baby from getting nourishment. It can also cause meningitis and pneumonia in an unborn baby, ending in possible death. Here are tips for preventing food poisoning:
Thoroughly cook raw food from animal sources such as beef, pork, or poultry.
Wash raw vegetables before eating.
Keep uncooked meats separate from vegetables and from cooked foods and ready-to-eat foods.
Don't drink raw (unpasteurized) milk or eat foods made from raw milk.
Wash your hands, knives, and cutting boards after handling uncooked foods.
Infections such as chlamydia may be linked to premature labor and rupture of the membranes.
This is a virus that causes inflammation of the liver. It may result in liver cell damage and destruction. There are 5 main types of the hepatitis virus. The most common type that happens in pregnancy is hepatitis B (HBV). This type spreads mainly through contaminated blood and blood products, sexual contact, and contaminated IV needles. HBV goes away in most people. But about 1 in 10 people will have chronic HBV. Hepatitis B virus can lead to chronic hepatitis, cirrhosis, liver cancer, liver failure, and death. Infected pregnant women can send the virus to the baby during pregnancy and at birth.
The later in pregnancy a mother gets the virus, the greater the chance for infection in her baby. Signs and symptoms of HBV are:
Yellowing of the skin, eyes, and mucous membranes (jaundice)
Severe tiredness (fatigue)
Loss of appetite
Nausea that comes and goes
A blood test for hepatitis B is part of routine prenatal testing. HBV positive mothers may get a medicine called hepatitis B immune globulin. Infants of HBV positive mothers should get hepatitis B immune globulin and the hepatitis B vaccine in the first 12 hours of birth. Babies of mothers with unknown HBV status should get the hepatitis B vaccine in the first 12 hours of birth. Babies of mothers who are negative for HBV should be vaccinated before leaving the hospital. Premature infants weighing less than 4.5 pounds (2,000 grams) born to mothers with negative HBV should have their first vaccine dose delayed until 1 month after birth or leaving the hospital. All babies should complete the hepatitis B vaccine series to be fully protected against hepatitis B infection.
A woman with HIV has a 1 in 4 chance of infecting her unborn baby. AIDS is caused by HIV. This virus kills or harms cells of the immune system. Over time it destroys the body's ability to fight infections and certain cancers. The term AIDS is used for the most advanced stages of an HIV infection. HIV is spread most often by sexual contact with an infected partner.
HIV may also be spread through contact with infected blood. This happens mostly by sharing needles, syringes, or drug use equipment with someone who has the virus. According to the National Institutes of Health, HIV is passed from mother to child during pregnancy, labor, and birth, or by breastfeeding. This makes up nearly all AIDS cases in U.S. children.
Some people may develop a flu-like illness within a month or two after exposure to the HIV virus. But many people don't have any symptoms at all when they first get infected. Lasting or severe symptoms may not show up for 10 years or more after HIV first enters the body in adults. Or they may show up within 2 years in children born with an HIV infection.
The American College of Obstetricians and Gynecologists advises HIV testing of all pregnant women. Prenatal care that includes HIV counseling, testing, and treatment for infected mothers and their children saves lives and resources. Current advice is for HIV-positive women to take medicines during pregnancy and during labor. Blood tests are also done to check the amount of virus. Newborn babies of HIV-positive mothers may also get medicine. Studies have found that giving a mother antiretroviral medicines during pregnancy, labor, and birth can lower the chance of passing the virus to the baby. This reduction is from 25% to less than 2%. Since the CDC began advising routine HIV screening for all pregnant women in 1995, the estimated numbers of mothers passing HIV to their children has dropped by about 85%. Cesarean delivery is often advised for HIV-positive women with a high level of the virus. Because breastmilk contains the virus, HIV positive women should not breastfeed their babies. Studies show that breastfeeding increases the risk for spreading the virus.
Genital herpes can be spread to the baby during birth if a woman has an active infection at that time. Herpes is caused by the herpes simplex virus (HSV). Herpes infections can cause blisters and ulcers on the mouth or face (oral herpes), or in the genital area (genital herpes). HSV is a life-long infection. Symptoms of HSV may include painful blisters or open sores in the genital area. A tingling or burning feeling in the legs, buttocks, or genital region may happen first. The herpes sores often go away in a few weeks. But the virus stays in the body, and the lesions may return from time to time.
It's important that women not get herpes during pregnancy. A first episode during pregnancy creates a greater risk of passing it on to the newborn. Women may be treated with an antiviral medicine if the disease is severe. Genital herpes can cause potentially deadly infections in babies if the mother has active genital herpes (is shedding the virus) at the time of birth. Cesarean section delivery is often advised for active genital herpes. Fortunately, infection of a baby is rare among women with genital herpes infection.
Protection from genital herpes includes not having sex when you have symptoms and always using latex condoms between outbreaks.
The Zika virus is spread mainly by infected mosquitoes. You can also get the Zika virus by having unprotected sex with someone who has the Zika virus. Babies who are infected before birth can have birth defects, such as microcephaly. This is when the baby’s head and brain are smaller than expected when compared to babies of the same gender and age. It may also cause other birth defects that affect the brain.
Don't travel to places with the risk of the Zika virus while you are pregnant. Use condoms with a partner who has the Zika virus or who has traveled to places with it. If you have to travel, talk with your healthcare provider about ways to prevent the spread of the virus.
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