condition Detailed information on autoimmune and metabolic liver disorders, including hemochromatosis (iron overload disorder) and Wilson disease. o

Detailed information on autoimmune and metabolic liver disorders, including hemochromatosis (iron overload disorder) and Wilson disease.

Other Liver Disorders

What are autoimmune liver disorders?

An autoimmune disorder is when your immune system attacks your organs or tissues by mistake. In the liver, the immune system can destroy liver cells and harm bile ducts. Long-term (chronic) hepatitis can be caused by an autoimmune disorder.

In autoimmune hepatitis, your immune system destroys liver cells. This condition may be called type 1 or type 2. The type depends on the type of antibodies attacking the liver cells.

Type 1 (classic) autoimmune hepatitis

This is the most common form. It may happen at any age. But it often affects young women more than men. Other autoimmune disorders can be linked to type 1. These include:

  • Thyroid diseases

  • Celiac disease. In this disease, eating gluten can harm the small intestine.

  • Ulcerative colitis or other inflammatory disease of the colon

Type 2 autoimmune hepatitis

This often affects girls between ages 2 and 14. Sometimes it affects adults.

What are metabolic liver disorders?

Two main metabolic disorders affect the liver.

Hemochromatosis

This disease is sometimes called iron overload disorder. Your body absorbs too much iron from food. The extra iron is stored all over the body, including the liver and pancreas. The extra iron can harm these organs. Hemochromatosis is an inherited disease. This means it is passed down through families. It can lead to liver disease, liver failure, liver cancer, heart disease, arthritis, skin darkening, and diabetes.

Wilson disease

With this disease, your body keeps too much copper in the liver. Over time, the damaged liver releases copper into the blood. This inherited disease can harm the kidneys, brain, and eyes. It can lead to severe brain damage, liver failure, and death.

Other conditions

Sometimes other metabolic liver conditions occur. These include alpha-1antitrypsin deficiency, Gaucher disease, and cystic fibrosis-related liver disease. Some are more common in children.

News & Publications

Quantity and Characteristics of Waste at a Level I Trauma Center

The purpose of this study was to quantify and describe the amount of waste generated by an Emergency Department, identify deviations from waste policy and explore areas for waste reduction.

The Climate-Smart Emergency Department: A Primer

Our publication keeps health care professionals up to date on the latest research and clinical advances from Mass General.

Research Institute Blog

News and notes from the largest hospital-based research program in the United States

Charged

A podcast devoted to uncovering the stories of Mass General's relentless pursuit to break boundaries and provide exceptional care