New details behind the body’s response to tuberculosis could lead to a more effective vaccine
Researchers uncover how the immune system clears, or in some cases helps, bacteria after infection.
Tuberculosis (TB) is a bacterial infection that often infects the lungs. Other organs, such as the kidneys, spine, or brain may also be affected.
Mass General for Children pediatric infectious disease specialists diagnose and treat the full range of infectious diseases and congenital and acquired immunodeficiencies in infants, children and adolescents.
In the Neurology-Infectious Diseases Program at Massachusetts General Hospital, we work with other infectious disease specialists to diagnose and treat infections of the nervous system, and neurological complications of systemic infections.
Tuberculosis (TB) is a bacterial infection that often infects the lungs. Other organs, such as the kidneys, spine, or brain, may also be affected. So can the lymph glands and other parts of the body. TB is mainly spread from person to person through the air, such as when someone with TB of the lungs coughs or sneezes. It can also become an active infection after not being active for a long time in someone who had been exposed.
There is a difference between being infected with TB bacteria and having active tuberculosis disease.
The stages of TB are:
Exposure. This happens when a person has been in contact with, or exposed to, another person who has TB. The exposed person will have a negative skin test, a normal chest X-ray, and no signs or symptoms of the disease.
Latent TB infection. This happens when a person has TB bacteria in their body but no symptoms of the disease. The infected person's immune system walls off the TB organisms. And the TB stays inactive throughout life in most people who are infected. This person would have a positive skin or blood test for TB but a normal chest X-ray or one that only shows past scarring from the disease. They would have no signs of active infection in other parts of the body.
TB disease. This person has signs and symptoms of an active TB infection. The person could have a positive or negative skin or blood test for TB and a positive chest X-ray, sputum culture, lung biopsy, or other finding showing an active infection.
The main TB bacterium is Mycobacterium tuberculosis (M. tuberculosis). Many people infected with this bacterium never have active TB. They remain in the inactive (latent) TB stage. But some will develop active TB anytime from months to years, or even decades, after being exposed. The chance of developing active TB is high in babies and children and in older adults. It also is more likely in people with a weak immune system. This includes people with HIV, an organ or stem cell transplant, or who are taking immune suppressing medicines.
The TB bacterium is spread through the air most often when a person with an active lung infection coughs, sneezes, speaks, sings, or laughs. It's very unlikely to be spread from personal items that a person with TB has touched. Good ventilation can limit the spread of TB to other people. But early diagnosis and treatment of the person with active TB is most important. It's also important to limit other people's exposure. This means using masks and respiratory isolation.
TB affects all ages, races, income levels, and genders. Those at higher risk include:
People who live or work with others who have TB
Those who can't access healthcare
People from countries where TB is more common
People in group settings, such as nursing homes
People who abuse alcohol
People who use injection drugs
People with a weak immune system, including those who have HIV, cancer, a transplant, or are taking medicines that suppress the immune system
Very young children and older adults
Healthcare workers who come in contact with high-risk populations
Each person's symptoms may vary. The most common symptoms of active TB include:
Prolonged cough lasting weeks
Feeling tired and weak (fatigue)
Loss of appetite
Unintended weight loss
Poor growth in children
Coughing blood or sputum
Shortness of breath
The symptoms of TB may look like other lung conditions or health problems. Talk with a healthcare provider for a diagnosis.
TB infection is often diagnosed with a skin or blood test. In the skin test (called a PPD), a small amount of testing material is injected into the top layer of the skin. If a certain size bump develops within 2 or 3 days, the test may be positive for TB infection. A blood test called QuantiFERON or T-SPOT may also be used. Other tests that may be key for diagnosing TB include X-rays and sputum tests.
TB skin or blood tests are suggested for people:
In high-risk categories
Who live or work in areas where TB is more common or are in close contact with people who have—or are at high risk for—TB
Who have never had a TB skin or blood test
In children, the American Academy of Pediatrics recommends testing:
If the child may have been exposed in the last 5 years
If the child has an X-ray that looks like TB
If the child has any TB symptoms
If the child comes from a country where TB is common
For children living with HIV
For children receiving medicines that suppress the immune system
For children who are in detention facilities
For children who are exposed to high-risk people
If the child's parent has come from a high-risk country
If the child has traveled to high-risk areas
If the child lives in a densely populated area
Treatment varies depending on if you have latent or active TB. Treatment may include:
Short-term hospital stay.
For latent TB. Often a 3- to 9-month course of 1 or 2 antibiotics will be given to kill off the TB organisms in the body. The most common antibiotics prescribed are rifampin, isoniazid, and rifapentine. Your healthcare provider can review the treatment choices. They may recommend 1 as the best choice for you, taking into account many factors.
For active TB. Your healthcare provider may prescribe 2 to 4 or more antibiotics in combination for 6 to 9 months or longer. Examples include isoniazid, rifampin, pyrazinamide, and ethambutol. People often begin to improve within a few weeks of starting treatment. After several weeks of treatment with the correct medicines, the person is often no longer contagious. But medicine must be finished for the greatest chance of cure, as prescribed by a healthcare provider.
If TB of the lung is not treated early or if treatment isn’t followed, long-lasting (permanent) lung damage can result. TB can also cause infection of the bones, spine, brain and spinal cord, lymph glands, and other parts of the body. It can damage those areas and cause short-term (temporary) or permanent symptoms from the damage. Uncontrolled TB can lead to death and remains a leading infectious cause of death worldwide.
If you will be spending time with anyone with active TB, wear a strongly filtering face mask. And try not to stay in a small, enclosed space with poor ventilation. People who work in situations where there is a high risk for contact with people infected with TB should be tested for TB on a routine basis. This includes healthcare and shelter workers. In countries outside the U.S. where TB is more common, a childhood vaccine called BCG is often given to babies and small children. But it does not always protect people from getting TB.
Let your healthcare provider know if your symptoms get worse or you get new symptoms.
Tuberculosis is a bacterial infection that often infects the lungs.
It may also affect the bones, spine, brain, lymph glands, and other parts of the body.
Being infected with the TB bacteria is not the same as having active tuberculosis disease.
There are 3 stages of TB: exposure, latent, and active disease.
A TB skin test or a TB blood test can often diagnose the infection. But other testing is also often needed.
Treatment exactly as recommended is needed to cure the disease and prevent its spread to other people.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your provider tells you.
At the visit, write down the name of a new diagnosis and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.
Know why a new medicine or treatment is prescribed and how it will help you. Also know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that visit.
Know how you can contact your provider if you have questions.
The purpose of this study was to quantify and describe the amount of waste generated by an Emergency Department, identify deviations from waste policy and explore areas for waste reduction.
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