Gut Microbiome Changes Linked to Precancerous Colon Polyps
Understanding the link between the gut microbiome and polyp growth opens the door to potential screenings and treatments.
About Daniel Chung, MD
Departments, Centers, & Programs:
Clinical Interests:
- Colon cancer screening
- Familial adenomatous polyposis / Gardner syndrome
- Familial pancreatic cancer
- Hereditary colon cancer
- Hereditary diffuse gastric cancer
- Lynch syndrome
Treats:
- Adult
Locations
Mass General Gastroenterology
55 Fruit St.
Boston, MA 02114
Phone: 617-724-5996
Medical Education
- MD, Harvard Medical School
- Residency, Massachusetts General Hospital*****
- Fellowship, Massachusetts General Hospital*****
American Board Certifications
- Gastroenterology, American Board of Internal Medicine
Accepted Insurance Plans
- Aetna Health Inc.
- Beech Street
- Blue Cross Blue Shield - Blue Care 65
- Blue Cross Blue Shield - Indemnity
- Blue Cross Blue Shield - Managed Care
- Blue Cross Blue Shield - Partners Plus
- BMC HealthNet Mass Health MCO/ACO
- Centene/Celticare
- Cigna (PAL #'s)
- Commonwealth Care Alliance
- Fallon Community HealthCare
- Great-West Healthcare (formally One Health Plan)
- Harvard Pilgrim Health Plan - ACD
- Harvard Pilgrim Health Plan - PBO
- Health Care Value Management (HCVM)
- Humana/Choice Care PPO
- Maine Community Health Options (MCHO)
- Mass General Brigham Health Plan - ACD
- Mass General Brigham Health Plan - PBO
- MassHealth
- Medicare
- Medicare - ACD
- Medicare ACO - ACD
- Medicare ACO - PBO
- OSW - Connecticut
- OSW - Maine
- OSW - New Hampshire
- OSW - Rhode Island
- OSW - Vermont
- Private Health Care Systems (PHCS)
- Railroad Medicare
- Railroad Medicare - ACD
- Senior Whole Health
- TriCare
- Tufts Health Plan
- Unicare
- United Healthcare (non-HMO) - ACD
- United Healthcare (non-HMO) - PBO
- Well Sense Pediatrics
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
- Genotype-phenotype correlations in hereditary cancer syndromes.
- Cancer surveillance in hereditary cancer syndromes.
- New approaches to colon cancer screening.
- The hypoxic microenvironment in colon cancer.
- Angiogenesis in colon cancer.
- Molecular genetics of gastroenteropancreatic neuroendocrine tumors.
Publications
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Select Publications:
- Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang XB, Zimmer MA, Iliopoulos O, Zukerberg LR, Lynch MP, Rueda BR, Chung DC. Induction of interleukin-8 preserves the angiogenic response in HIF-1 deficient colon cancer cells. Nature Medicine, 2005, 11:992-97.
- Pino MS, Kikuchi H, Zeng M, Herraiz MT, Sperduti I, Berger D, Park DY, Iafrate AJ, Zukerberg LR, Chung DC. The epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. Gastroenterology. 2009 Dec 21
- Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC. Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. Gastroenterology. 2014;146(2):520-9. PMID: 24512911
- Adar T, Rodgers LH, Shannon KM, Yoshida M, Ma T, Mattia A, Lauwers GY, Iafrate AJ, Chung DC. A tailored approach to BRAF and MLH1 methylation testing in a universal screening program for Lynch syndrome. Mod Pathol. 2017;30(3):440-7. PMID: 28059100.
- Adar T, Rodgers LH, Shannon KM, Yoshida M, Ma T, Mattia A, Lauwers GY, Iafrate AJ, Hartford NM, Oliva E, Chung DC. Universal screening of both endometrial and colon cancers increases the detection of Lynch syndrome. Cancer. 2018 May 11. PMID: 29750335
- Nguyen LH, Goel A, Chung DC. Pathways of colorectal carcinogenesis. Gastroenterology. 2019 Oct 14. pii: S0016-5085(19)41441-8. doi: 10.1053/j.gastro.2019.08.059. PMID: 3162262