When Boston began to take COVID-19 pandemic precautions last year, the Boston Lyric Opera had just opened a production of Bellini’s Norma. Artistic director Esther Nelson turned to a longtime friend of the organization to help them determine whether the season could go on.
David Hooper, MD
David Hooper, MD
Associate Chief, Division of Infectious Diseases
Departments, Centers, & Programs:
Mass General Infectious Diseases
55 Fruit St.
Boston, MA 02114
- MD, Washington University School of Medicine in St. Louis
- Residency, Massachusetts General Hospital
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Infectious Disease, American Board of Internal Medicine
- Internal Medicine, American Board of Internal Medicine
Accepted Insurance Plans
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My laboratory studies the mechanisms and epidemiology of antibiotic resistance in bacteria with a major focus on the molecular determinants of quinolone action and resistance in Staphylococcus aureus and Escherichia coli. The work includes characterization of the regulation of expression, membrane topology, and structure-activity relationships of the NorA and related quinolone efflux transport proteins of S. aureus; genetic dissection of the roles of topoisomerase IV and DNA gyrase in DNA replication, in regulation of virulence gene expression, and as drug targets; epidemiologic analyses of quinolone resistance and factors determining rates of antibiotic resistance in hospitals; molecular determinants favoring clonal spread of vancomycin-resistant Enterococcus faecium; and role of perioperative antibiotic use in selection of resistant bacteria.
Hooper DC. Quinolones. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. 7th edition. Philadelphia: Elsevier Churchill Livingstone Inc., 2009; 487-510.
Hooper DC. Urinary tract agents. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. 7th edition. Philadelphia: Elsevier Churchill Livingstone Inc., 2009; 515-520.
Peleg AY, Hooper DC. Hospital-acquired infections due to gram-negative bacteria. N. Engl. J. Med. 2010; 362:1804-1813.