About David Hooper, MD

Departments, Centers, & Programs:

Clinical Interests:

Treats:

Locations

Infectious Disease Associates
55 Fruit Street
Boston, MA 02114-2696
Phone: 617-726-3812
Fax: 617-726-7416

Medical Education

  • MD, Washington University School of Medicine in St. Louis
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Internal Medicine, American Board of Internal Medicine
  • Infectious Disease, American Board of Internal Medicine

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Research

My laboratory studies the mechanisms and epidemiology of antibiotic resistance in bacteria with a major focus on the molecular determinants of quinolone action and resistance in Staphylococcus aureus and Escherichia coli. The work includes characterization of the regulation of expression, membrane topology, and structure-activity relationships of the NorA and related quinolone efflux transport proteins of S. aureus; genetic dissection of the roles of topoisomerase IV and DNA gyrase in DNA replication, in regulation of virulence gene expression, and as drug targets; epidemiologic analyses of quinolone resistance and factors determining rates of antibiotic resistance in hospitals; molecular determinants favoring clonal spread of vancomycin-resistant Enterococcus faecium; and role of perioperative antibiotic use in selection of resistant bacteria.

Publications

  • Hooper DC. Quinolones. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. 7th edition. Philadelphia: Elsevier Churchill Livingstone Inc., 2009; 487-510.

    Hooper DC. Urinary tract agents. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. 7th edition. Philadelphia: Elsevier Churchill Livingstone Inc., 2009; 515-520.

    Peleg AY, Hooper DC. Hospital-acquired infections due to gram-negative bacteria. N. Engl. J. Med. 2010; 362:1804-1813.