About Joren Madsen, MD, Dphil

Joren C. Madsen, MD, DPhil received his bachelor's degree from Brown University and his medical degree from the University of Massachusetts Medical School in 1982. After completing his first three years of general surgery training at Mass General, he was awarded the Claude E. Welch Surgical Research fellowship to study at Oxford University. His work there culminated in a doctorate degree from Balliol College in Immunology. Dr. Madsen completed his surgical residency in 1990 and went on to train in cardiothoracic surgery at Mass General and Boston Children's Hospital. He joined the Division of Cardiac Surgery in 1993.

Currently, Dr. Madsen is Professor of Surgery at Mass General and the Paul S. Russell/Warner-Lambert Professor of Surgery at Harvard Medical School.  He directs the Transplant Center, which encompasses kidney, liver, lung, heart, pancreas and small bowel transplantation in adults and children. He is also Co-Director of the Center for Transplantation Science (CTS), a large,  basic and translational research laboratory studying transplantation immunology. Dr. Madsen divides his time between cardiac transplant surgery, transplant immunology research, teaching and administration. His academic interests have focused on transplantation tolerance, chronic rejection, innate immunity, and xenotransplantation. He has a strong commitment to both clinical and scientific education, having mentored over 30 pre- and post-doctoral fellows in his laboratory.

Dr. Madsen curently serves on the editorial board of the American Journal of Transplantation. He is a past president of the American Society of Transplantation, the first surgeon to be elected to that position.

Clinical Interests:

Treats:

Locations

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114-2696
Primary:617-726-6506
Secondary:617-643-4808
Fax: 617-726-4067

Medical Education

  • DPHIL, Oxford University
  • MD, University of Massachusetts Medical School
  • Residency, Boston Children's Hospital
  • Residency, Massachusetts General Hospital

Accepted Insurance Plans

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Research

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Dr. Madsen leads three interrelated research groups that study the molecular and cellular mechanisms of transplant rejection and immune tolerance in mice, swine and nonhuman primates, respectively. By understanding the biological of these processes Madsen hopes to find ways to prolong organ allograft survival (inducing tolerance), extend transplant recipients lives (preventing chronic rejection) and increase the organ donor pool (pig-to-human xenotransplantation). Dr. Madsen's laboratory has been the first to induce long term tolerance of cardiac allografts in large animals and to demonstrate the natural killer cells contribute to cardiac allograft vasculopathy. He has been continuously funded by the NIH since 1995.

In 2002, he received the Fujisawa Basic Science Award from the American Society of Transplantation. In 2005, he was made the W. Gerald and Patricia R. Austen Distinguished Scholar in Cardiac Surgery at Massachusetts General Hospital. In 2009, he was elected president of the American Society of Transplantation. In 20016 he was made the Paul S. Russell/Warner-Lambert Professor of Surgery at Harvard Medical School.

Publications