About Lawrence Zukerberg, MD
Dr. Zukerberg has expertise in gastrointestinal, hematological, and frozen section pathology. He is the Principal Investigator with a research program focused on studying the biology and biochemistry of a novel gene, Cables that interacts with cell cycle control proteins including, CDK2, p53, beta-catenin, mTOR and is a novel cell cycle regulator and tumor suppressor gene. Cables expression is lost in many primary human cancer and it loss can prolong the life of stem cells in some mouse organs. Some of the research projects of Dr. Zukerberg include studying the relationship of Cables to cell cycle control proteins, generating and studying Cables mutant mice, and determining the pathways involved in Cables cell growth regulation. Other recent projects have included identification of cyclin D1 as a marker of mantle cell lymphoma and understanding specific reactive conditions that mimic lymphoma.
Departments, Centers, & Programs:
Clinical Interests:
- Gastrointestinal cancer
- Liver cancer
- Pancreatic cancer
Treats:
- Adult
Locations
Mass General Pathology
55 Fruit St.
Boston, MA 02114
Phone: 617-643-0800
Medical Education
- MD, UMDNJ- Rutgers Medical School
- Residency, Massachusetts General Hospital
- Fellowship, Massachusetts General Hospital
- Fellowship, University of Michigan Hospital
American Board Certifications
- Anatomic Pathology & Clinical Pathology, American Board of Pathology
- Pathology, American Board of Pathology
Accepted Insurance Plans
- Aetna Health Inc.
- AllWays Health (NHP) - ACD
- AllWays Health (NHP) - PBO
- BCBS Anthem - NH
- Beech Street
- Blue Cross Blue Shield - Blue Care 65
- Blue Cross Blue Shield - Indemnity
- Blue Cross Blue Shield - Managed Care
- Blue Cross Blue Shield - Partners Plus
- BMC HealthNet Mass Health MCO/ACO
- Centene/Celticare
- Cigna (PAL #'s)
- Commonwealth Care Alliance
- Fallon Community HealthCare
- Great-West Healthcare (formally One Health Plan)
- Harvard Pilgrim Health Plan - PBO
- Health Care Value Management (HCVM)
- Humana/Choice Care PPO
- Maine Community Health Options (MCHO)
- MassHealth
- Medicare
- Medicare - NH
- OSW - Connecticut
- OSW - Maine
- OSW - New Hampshire
- OSW - Rhode Island
- OSW - Vermont
- Private Health Care Systems (PHCS)
- Railroad Medicare
- Senior Whole Health
- TriCare
- Tufts Health Plan
- Unicare
- United Healthcare (non-HMO) - PBO
- Well Sense Health Plan NH
- Well Sense Pediatrics
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
We have recently cloned a novel protein, Cables, which maps to human chromosome 18q and inhibits growth of cells in culture and tumor formation in animal models. Our studies will define a novel target for the deletions commonly seen on chromosome 18q. Ultimately, these studies will lay the foundation for new therapeutic approaches. See details at the Zukerberg Lab. For more information about research concepts, co-authors, and to see a timeline, visit Dr. Zukerberg's profile at the Harvard Clinical and Translational Science Center.
Publications
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- Arnason T, Pino MS, Yilmaz O, Kirley SD, Rueda BR, Chung DC, Zukerberg LR. Cables 1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc (Min) mice. Cancer Biol Ther. 2013. 2013;14:672-678.
- Nazarian RM, Primiani A, Doyle LA, Linskey KR, Duncan LM, Odze RD, Zukerberg LR. Cytokeratin 17: an adjunctive marker of invasion in squamous neoplastic lesions of the anus. American Journal Surgical Pathology 2014;38:78-85.
- Zukerberg L, Mahadevan K, Selig M, Deshpande V. Oesophageal intrasquamous IgG4 deposits: an adjunctive marker to distinguish eosinophilic