About Steven Grinspoon, MD

Dr. Steven Grinspoon, Unit Chief of the Metabolism Unit, is a Professor of Medicine at Harvard Medical School, Director of the Nutrition Obesity Research Center at Harvard and the Massachusetts General Hospital Endowed Chair in Neuroendocrinology and Metabolism. He is a member of the American Society of Clinical Investigation and the Association of American Physicians. He received the 2014 Edward H. Ahrens Jr. Award for Patient Oriented Research from the Association for Clinical and Translational Science (ACTS) and was recently named to receive the 2016 Gerald Aurbach Laureate Award from the Endocrine Society for Translational Research.

Departments, Centers, & Programs:

Clinical Interests:



Mass General Endocrinology: Lipid Metabolism Unit
55 Fruit St.
Boston, MA 02114
Phone: 617-643-5588

Mass General Endocrinology: Neuroendocrine & Pituitary Tumor Clinical Center
55 Fruit St.
Boston, MA 02114
Phone: 617-726-7948

Medical Education

  • MD, University of Rochester School of Medicine and Dentistry
  • Residency, Columbia Presbyterian Hospital
  • Residency, New York Presbyterian Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Endocrinology, Diabetes and Metabolism, American Board of Internal Medicine

Accepted Insurance Plans

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Dr. Grinspoon is a clinical researcher who studies the development of novel metabolic and neuroendocrine strategies to reduce cardiovascular and metabolic risk associated with excess visceral fat, with a focus on the use of growth hormone releasing hormone (GHRH) to increase endogenous pulsatile GH, and selectively reduce visceral fat. His research interests include metabolic consequences of visceral fat accumulation in lipodystrophy and obesity.


  • Hadigan C, Yawetz S, Thomas A, Havers F, Sax PE, Grinspoon S.  Effects of Rosiglitazone on Metabolic Indices and Fat in HIV Lipodystrophy: A Randomized Controlled Trial.  Ann Intern Med. 2004; 140: 786 - 794.

    Falutz J, Allas S, Blot K, Potvin D, Kotler D, Somero M, Berger B, Brown S, Richmond G, Fessel J, Turner R, Grinspoon S. Metabolic Effects of a Growth Hormone-Releasing Factor in HIV Patients. N Engl J Med 2007; 357:2359-70.

    Lo J, You SM, Canavan B, Liebau J, Beltrani G, Koutkia P, Hemphill L, Lee H, Grinspoon S. Low Dose Physiologic Growth Hormone in HIV Patients with Abdominal Fat Accumulation: A Randomized Controlled Trial. JAMA. 2008; 300:509-519. PMCID: PMC2532757

    Subramanian S*, Tawakol A*, Burdo T, Abbara S, Wei, J, Vijayakumar J, Corsini E, Abdelbarky A, Zanni M, Hoffman U, Williams K, Lo J†, Grinspoon S†. Arterial Inflammation in HIV-Infected Patients. JAMA 2012. Jul 25;308(4):379-86. PMCID: PMC3724172

    Stanley TL, Feldpausch M, Oh J, Branch K, Lee H, Torriani M, Grinspoon SK. Effects of Tesamorelin on Visceral Fat and Liver Fat in HIV-infected Patients with Abdominal Fat Accumulation: A Randomized Clinical Trial. JAMA. 2014 Jul 23-30;312(4):380-9. PMID:25038357

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