About Kevin Hughes, MD

Dr. Hughes has over 25 years of experience caring for women with breast cancer and breast diseases. Dr. Hughes is a member of the Division of Gastrointestinal and Oncologic Surgery at Massachusetts General Hospital, Professor of Surgery at Harvard Medical School, and Medical Director of the Bermuda Cancer Genetics Risk Assessment Clinic. Dr. Hughes is a graduate of Dartmouth College and Dartmouth Medical School. He trained at the Mercy Hospital of Pittsburgh for general surgery, followed by a fellowship in Surgical Oncology at the National Cancer Institute. Dr. Hughes is actively involved in research regarding the genetics, screening, diagnosis and treatment of breast cancer. He is part of a multidisciplinary team of Medical Oncologists, Radiation Oncologists and Plastic Surgeons working together to provide the best care possible for women with breast cancer and other breast diseases. He has had a major role in developing the standards and guidelines that are designed to improve breast cancer care for all women and has an active interest in using Artificial Intelligence to review and organize the medical literature regarding hereditary cancer.

Dr. Hughes was named:

  • One of Boston Magazine's Top Docs 2008 thru 2020
  • One of America's Top Doctors for Cancer every year since 2005
  • One of America's Top Doctors every year since 2005



Departments, Centers, & Programs:

Clinical Interests:



Surgical Oncology Associates
55 Fruit Street
Boston, MA 02114-2696
Phone: 617-724-4800
Fax: 617-724-3895

Avon Center
15 Parkman Street
Boston, MA 02114-3117
Phone: 617-726-9200
Fax: 617-726-9210

Medical Education

  • MD, Dartmouth Medical School
  • Residency, Mercy Hospital of Pittsburgh
  • Fellowship, National Cancer Institute
  • Fellowship, Nat'l Cancer Institute

American Board Certifications

  • Surgery, American Board of Surgery

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Dr. Hughes is actively involved in research regarding:


  • Genetics and risk factors for breast cancer
  • Machine learning and artificial intelligence
  • Breast density
  • Diagnostic approaches to breast disease and breast cancer
  • Treatment of breast cancer
  • Clinical Decision Support


  • Select Publications:

    • Breast imaging, breast surgery, and cancer genetics in the age of COVID-19. Cancer. 2020 Oct 15;126(20):4466-4472. doi: 10.1002/cncr.33113. Epub 2020 
    • Yin K, ... Hughes KS. Legacy Genetic Testing Results for Cancer Susceptibility: How Common are Conflicting Classifications in a Large Variant Dataset from Multiple Practices? Ann Surg Oncol. 2020 Jul;27(7):2212-2220. doi: 10.1245/s10434-020-08492-9. Epub 2020 Apr 27. 
    • Performance of Breast Cancer Risk-Assessment Models in a Large Mammography Cohort. J Natl Cancer Inst. 2020 May 1;112(5):489-497. doi: 10.1093/jnci/djz177. PMID: 31556450; PMCID: PMC7225681.
    • Penetrance of Colorectal Cancer Among Mismatch Repair Gene Mutation Carriers: A Meta-Analysis. JNCI Cancer Spectr. 2020 Apr 23;4(5)
    • Natural language processing to facilitate breast cancer research and management. Breast J. 2020 Jan;26(1):92-99. doi: 10.1111/tbj.13718. Epub 2019 Dec 18. 
    • Using Machine Learning and Natural Language Processing to Review and Classify the Medical Literature on Cancer Susceptibility Genes. JCO Clin Cancer Inform. 2019 Sep;3:1-9. 
    • Validation of a Semi-automated Natural Language Processing-Based Procedure for Meta-Analysis of Cancer Susceptibility Gene Penetrance. JCO Clin Cancer Inform. 2019 Aug;3:1-9.
    • A Clinical Decision Support Tool to Predict Cancer Risk for Commonly Tested Cancer-Related Germline Mutations. J Genet Couns. 2018 Sep;27(5):1187-1199. doi: 10.1007/s10897-018-0238-4. Epub 2018 Mar 2.