About Ken Solt, MD

Departments, Centers, & Programs:

Clinical Interests:

Treats:

Languages:

Locations

Anesthesia, Critical Care and Pain Medicine
55 Fruit Street
Boston, MA 02114-2696
617-726-4359
Fax: 617-724-5541

Medical Education

  • MD, University of Pennsylvania School of Medicine
  • Residency, Massachusetts General Hospital

American Board Certifications

  • Anesthesiology, American Board of Anesthesiology

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Research

I study the mechanisms of emergence and cognitive recovery from general anesthesia using a systems neuroscience approach. In current clinical practice, emergence from general anesthesia is treated as a passive process dictated by the pharmacokinetics of anesthetic drug clearance. My group discovered that methylphenidate (Ritalin) and dopamine agonists induce active emergence from general anesthesia, a process that we term "reanimation." We subsequently discovered that electrical stimulation of the ventral tegmental area (VTA), a key dopamine nucleus in the midbrain, also induces reanimation.

I currently direct a translational research program that studies the role of dopamine pathways in restoring consciousness and cognition after general anesthesia. In my laboratory, we combine intracranial stimulation, neurophysiological recordings, and cognitive testing in rodents to elucidate the neural circuits that govern reanimation, while my clinical research program tests novel methods to accelerate recovery of consciousness and cognition in surgical patients. Our long-term goal is to make general anesthesia safer by developing new therapeutic options for common clinical problems such as post-operative delirium and cognitive dysfunction.

Publications