Mass General and Mass General Brigham have made a huge investment in genome sequencing and research to figure out how to relate disease to novel genetic variants, and how that fits into a future personalized approach to our neurology patients, and patients in general.
Departments, Centers, & Programs:
55 Fruit Street
Boston, MA 02114-2696
Renee Mendes, Patient Services Coordinator: 617-724-6510
- MD, UC San Diego School of Medicine
- Residency, UC San Diego Main Campus
- Residency, University of Colorado Health Center
- Fellowship, Stanford University Medical Center
American Board Certifications
- Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology
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Our long-term research goal is the development of new approaches to the treatment of epilepsy based on a clearer understanding of the necessary steps in seizure initiation and propagation.
The two major themes in the lab are neuronal ion transport and the spread of activity in neural networks. Neuronal ion transport underlies signaling at all fast synapses. The importance of neuronal ion transport was underscored by our recent discovery that reversed ion transport in the immature brain was blocking the effects of the anticonvulsants most commonly used to treat neonatal seizures, and that a safe and well-characterized diuretic could ameliorate this condition.
Our work on the spread of excitation in neural networks combines fluorescent imaging of network activity with computerized analysis and modeling to understand how normal and abnormal signaling progresses through neural networks. We have found evidence for reentrant or circular patterns of neural activity that resemble cardiac fibrillation and precede seizures. We are currently testing whether this reentrant activation of neural circuits is the earliest stage of a seizure, and the stage at which intervention is most effective. We are also testing whether long-term reductions in the strength of synaptic connections between neurons in epileptic networks can reduce the probability of seizures.
- Glykys J, Staley KJ. Diazepam effect during early neonatal development correlates with neuronal CL. Annals of Clinical Neurology, September 16, 2015, doi: 10.10002/acn7.259
- Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-Rachamimov A, Staley KJ. Failure to detect human papillomavirus in focal cortical dysplasia type II, Annals of Neurology, Volume 78, Number 1, 1 July 2015, pp. 63-67
- Dzhala V, Staley KJ. Acute and Chronic Efficacy of Bumetanide in an in vitro Model of Posttraumatic Epileptogenesis. CNS Neurosci Ther. 2015 Feb; 21(2):173-80.
- Lillis KP, Wang Z, Berdichevsky Y, Mail M, Zhao G, Bacskai B, Staley KJ. Evolution of network synchronization during early epileptogenesis parallels synaptic circuit alterations. J Neurosci., 2015 Jul 8; 35(27):9920-34
- Kyung-Il Park, Volodymyr Dzhala, Yero Saponjian, Kevin J. Staley. What elements of the inflammatory system are necessary for epileptogenesis In Vitro. eNeuro. Mar 2015, 2 (2) DOI: 10.1523/ENEURO.0027-14.2015
- Lillis KP, Dulla C, Maheshwari A, Coulter D, Mody I, Heinemann U, Armbruster M, ?iburkus J., WONOEP appraisal: Molecular and cellular imaging in epilepsy. Epilepsia 56:505–513. 2015
- Kevin Staley, Molecular Mechanisms of Epilepsy. Nature Neuroscience. 18, 367-372, doi:10.1038/nn 3947, 2015