Dr. Udo Hoffmann is a cardiac radiologist with 15+ years of experience in magnetic resonance and computed tomography imaging research. His current focus is the value and accuracy of cardiac CT in an array of clinical applications.
His past research interests related to a multidisciplinary research approach to systematically assess and validate the clinical utility of novel cardiovascular imaging technologies from bench to bedside. Over the last 15 years he has worked on the technical, analytical, clinical, epidemiological, and economic aspects of invasive and noninvasive imaging of atherosclerosis. One of the most daunting challenges has been to translate early technical progress in imaging into improvement of the clinical management of patients. The assessment and validation of biomarkers for clinical outcomes in cardiovascular imaging is still an important focus.
Dr. Hoffmann is a member of national initiatives, committees, and task forces for the RSNA, ACR, SCAI, AHA, and ACC, and serves as the director of several cardiovascular imaging courses. Dr Hoffmann, who has published over 200 papers, reviews and book chapters, is Co-Chair of the Imaging Oversight Committee of the Framingham Heart Study, and an Associate Editor for Circulation Imaging and European Journal of Radiology. He is supported by a staff of 25 including MD radiologists/cardiologists, project managers, CT technologists, and IT staff/ programmers.
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My primary research interests relate to a multidisciplinary research approach to systematically assess and validate the clinical utility of novel cardiovascular imaging technologies from bench to bedside. Over the last 10 years I have worked on the technical, analytical, clinical, epidemiological, and economic aspects of invasive and noninvasive imaging of atherosclerosis. One of the most daunting challenges is to translate early technical progress in imaging into improvement of the clinical management of patients. I am studying the assessment and validation of cardiovascular imaging biomarkers for clinical outcomes within several large NIH-sponsored comparative effectiveness trials with >10000 patients.
Hoffmann U, Bamberg F, Chae CU, Nichols JH, Rogers IS, Seneviratne SK, Truong QA, Cury RC, Abbara S, Shapiro MD, Moloo J, Butler J, Ferencik M, Lee H, Jang IK, Parry BA, Brown DF, Udelson JE, Achenbach S, Brady TJ, Nagurney JT. Coronary computed tomography angiography for early triage of patients with acute chest pain: the ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) trial. J Am Coll Cardiol. 2009; 53(18):1642-50. PMID: 19406338
Hoffmann U, Moselewski F, Nieman K, Jang IK, Ferencik M, Rahman AM, Cury RC, Abbara S, Joneidi-Jafari H, Achenbach S, Brady TJ. Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography. J Am Coll Cardiol. 2006; 47(8):1655-62. PMID: 16631006
Bamberg F, Truong QA, Blankstein R, Nasir K, Lee H, Rogers IS, Achenbach S, Brady TJ, Nagurney JT, Reiser MF, Hoffmann U. Usefulness of age and gender in the early triage of patients with acute chest pain having cardiac computed tomographic angiography. Am J Cardiol. 2009; 104(9):1165-70. PMID: 19840556
Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, Wolf PA, O'Donnell CJ, Fox CS, Hoffmann U. Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study. Eur Heart J. 2009; 30(7):850-6. PMID: 19136488
Hoffmann U, Massaro JM, Fox CS, Manders E, O'Donnell CJ. Defining normal distributions of coronary artery calcium in women and men (from the Framingham Heart Study). Am J Cardiol. 2008 Nov 1;102(9):1136-41. PMID: 18940279
