About Anthony Iafrate, MD, PhD
Dr. Iafrate is a Professor of Pathology at Harvard Medical School, former Director of the Center for Integrated Diagnostics (CID), a clinical laboratory for molecular diagnostics at Massachusetts General Hospital and is currently the Vice Chair of Academic Affairs at the Massachusetts General Hospital (MGH). Dr. Iafrate received his MD/PhD dual degree from the State University of New York at Stony Brook in 2000 and was trained in anatomic and molecular genetic pathology at Brigham and Women’s Hospital. Dr. Iafrate is a board-certified Pathologist and has been on staff at MGH since 2005. The CID provides rapid personalized genomic testing to help inform cancer treatment decisions for patients. His research is focused on lung and brain tumors, where he has been closely involved in the clinical development of crizotinib and companion diagnostics in ALK- and ROS1 positive lung cancers. His lab has developed several technologies for sequencing tumors, including SNaPshot and the next-generation sequencing-based Anchored Multiplex PCR, both techniques have been widely used in the molecular diagnostics community.
Departments, Centers, & Programs:
Clinical Interests:
- Molecular pathology
Treats:
- Adult
Locations
Mass General Pathology
55 Fruit St.
Boston, MA 02114
Phone: 617-643-0800
Medical Education
- MD, State University of New York, Stony Brook School of Medicine And Biomedical Sciences
- Residency, Brigham and Women's Hospital
- Fellowship, Brigham and Women's Hospital
American Board Certifications
- Anatomic Pathology, American Board of Pathology
- Molecular Genetic Pathology, American Board of Medical Genetics and Genomics
Accepted Insurance Plans
- Aetna
- Beech Street
- Blue Cross Blue Shield
- Blue Cross Blue Shield Medicare
- Cigna
- Commonwealth Care Alliance
- Coventry
- Fallon Health
- Harvard Pilgrim Health Care
- Humana
- Maine Community Health Options
- Mass General Brigham Health Plan
- MassHealth
- Medicaid ME
- Medicaid NH
- Medicaid RI
- Medicaid VT
- Medicare
- Medicare ACO
- Multiplan
- Railroad Medicare
- Senior Whole Health
- TriCare
- Tufts Health Plan
- Unicare
- United Health Care
- WellSense
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
Research in the Iafrate laboratory focuses on bringing new genetic technologies to cancer diagnostics and their application to the practice of pathology. Initially research focused on lung cancer, but our approach is expanding to all malignancies. For more information about research concepts, co-authors, and to see a timeline, visit Dr. Iafrate's profile at the Harvard Clinical and Translational Science Center.
Publications
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- Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival. Batal I, De Serres SA, Safa K, Bijol V, Uneo T, Onozato ML, Iafrate AJ, Herter JM, Lichtman AH, Mayadas TN, Guleria I, Rennke HG, Najafian N, Chandraker A. J Am Soc Nephrol. 2015 Apr 8. Epub ahead of print]
- RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Niederst MJ, Sequist LV, Poirier JT, Mermel CH, Lockerman EL, Garcia AR, Katayama R, Costa C, Ross KN, Moran T, Howe E, Fulton LE, Mulvey HE, Bernardo LA, Mohamoud F, Miyoshi N, VanderLaan PA, Costa DB, J??nne PA, Borger DR, Ramaswamy S, Shioda T, Iafrate AJ, Getz G, Rudin CM, Mino-Kenudson M, Engelman JA. Nat Commun. 2015 Mar 11;6:6377.
- Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience. Sholl LM, Aisner DL, Varella-Garcia M, Berry LD, Dias-Santagata D, Wistuba II, Chen H, Fujimoto J, Kugler K, Franklin WA, Iafrate AJ, Ladanyi M, Kris MG, Johnson BE, Bunn PA, Minna JD, Kwiatkowski DJ; LCMC Investigators. J Thorac Oncol. 2015 May;10(5):768-77.