About George Papakostas, MD

Dr. George I. Papakostas is Associate Executive Director Director of the Massachusetts General Hospital Clinical Trials Network and Institute, and Professor of Psychiatry at Harvard Medical School in Boston, Massachusetts. He is also Director of a Harvard-Wide course on the Design and Conduct of Clinical Trials in Medicine.

The focus of Dr Papakostas’ research includes the pharmacotherapy of major depressive disorder including treatment-resistant depression, as well as the study of successful clinical trial methodology in Neuropsychiatric disorders. Dr. Papakostas prominence a researcher in the field is reflected in his position as overall Principal Investigator of the PCORI-funded ASCERTAIN-TRD trial aimed at comparing augmentation versus switching in TRD, and also served as co-Principal Investigator of the RAPID Network, the NIMH-funded series of studies of novel, rapidly-acting antidepressant therapies for TRD.

Dr Papakostas has received numerous national and international research awards from sources including the American College of Neuropsychopharmacology, the Collegium Internationale Neuropsychopharmacologium, the American Society of Clinical Psychopharmacology, the American Psychiatric Association, the World Federation of Societies of Biological Psychiatry, the American Academy of Clinical Psychiatrists, the International College of Psychosomatic Medicine, and the American Foundation for Suicide Prevention.

He is author or co-author of over 200 clinical and scientific publications and book chapters, is author of the book entitled: “Pharmacotherapy for Depression” (World Scientific Publishing and Imperial College Press), and has been awarded two patents by the U.S. Patent Office on novel approaches to treat depression. Dr. Papakostas is often invited throughout the United States and abroad to lecture on a wide range topics pertaining to the treatment of depression. To date, he has delivered hundreds of lectures at National or International meetings in more than 40 countries. Dr Papakostas maintains an active clinical practice in Boston, Massachusetts and is listed among the Best Doctors in North America. (Woodward/White, Inc. Aiken, SC).

Departments, Centers, & Programs:

Clinical Interests:



Clinical Trials Network and Institute
One Bowdoin Square
9th Floor
Boston, MA 02114-2790
Phone: 617-726-8895
Fax: 617-726-7541

Medical Education

  • MD, New York University
  • Residency, Massachusetts General Hospital

American Board Certifications

  • Psychiatry, American Board of Psychiatry and Neurology

Accepted Insurance Plans

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Dr. Papakostas is involved in overseeing numerous studies focusing on the diagnosis, treatment, and management of Major Depressive Disorder that is resistant or refractory to standard therapy. He is also active in educating clinicians locally, regionally, nationally, and internationally on the management of major depressive disorder, as well as in disseminating cutting-edge research in this field of study through numerous manuscripts published in top-notch scientific journals.