Approximately one-fourth of ARDS patients have disease features that put them at increased risk of death within the first month of hospitalization.
Departments, Centers, & Programs:
Anesthesia, Critical Care and Pain Medicine
55 Fruit Street
Boston, MA 02114-2696
- MD, Universita Degli Studi Di Milano
- MD, University of Milan
- Residency, Massachusetts General Hospital
- Residency, University of Milan
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Critical Care Medicine, American Board of Anesthesiology
- Anesthesiology, American Board of Anesthesiology
Accepted Insurance Plans
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- Alterations of the Nitric Oxide Physiology in the presence of circulation plasma cell-free hemoglobin.
- Emerging approaches in the prevention of Ventilator Acquired Pneumonia.
- Characteristics of the inflammatory response of patients undergoing surgical procedures.
- Acute Respiratory Distress Syndrome (ARDS).
Description of Research
In my early research career I worked at the National Institutes of Health, under the supervision of my mentor Dr. Theodore Kolobow (2000-2005). We developed several new methods and medical devices to avoid aspiration and ventilator associated pneumonia: such as novel rotating beds, care of intubated patients, novel endotracheal tube designs, new methods of ventilation, and novel approach to prevent bacterial colonization of the respiratory tract. In animal models we experimented and successfully showed feasibility and efficacy of those methods. In order to test these hypotheses and other novel approaches to prevent lung injury in mechanically ventilated patients, Dr. Robert Kacmarek and I established a Respiratory and Critical Care Research Team in the department of Anesthesia, Critical Care and Pain Medicine at MGH. Under the mentorship of Dr. Warren Zapol, I also expanded my studies on the role of transfusion and hemolysis on hemodynamics, inflammation, endothelial dysfunction and organ dysfunction.
- Press Release
- Aug | 27 | 2020
Mass General study shows the benefits of inhaled nitric oxide therapy for pregnant patients with severe and critical COVID-19
The delivery of the therapeutic gas to six COVID-19 pregnant patients resulted in a rapid and sustained improvement in cardiopulmonary function and decreased inflammation.
- Mar | 3 | 2020
Massachusetts General Hospital researchers have pioneered an individualized approach to the care of patients with acute respiratory distress syndrome and class III obesity who are receiving mechanical ventilation.
- Press Release
- Jan | 16 | 2020
Mortality rate is cut in half by a Lung Rescue Team at Mass General focused on patients with obesity and acute respiratory failure
A specialized Lung Rescue Team established to evaluate and treat patients with obesity receiving mechanical ventilation due to acute respiratory failure has significantly reduced the risk of mortality compared to standard treatment.