Investigators uncover 10 skin-related conditions linked to immune checkpoint inhibitors and identify which patients are more likely to develop them.
Departments, Centers, & Programs:
MGH Cancer Center, Bartlett Hall
55 Fruit Street
Boston, MA 02114
- MD, University of Missouri Hospitals and Clinics
- MD, University of Missouri School of Medicine
- Residency, Massachusetts General Hospital
- Residency, MGH
- Fellowship, Dana Farber Cancer Institute
- Fellowship, MGH
American Board Certifications
- Medical Oncology, American Board of Internal Medicine
- Internal Medicine, American Board of Internal Medicine
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We are in the midst of an exciting revolution in the treatment of cancer. By harnessing and enhancing the body’s immune system using novel therapies such as immune checkpoint inhibitors, we can reduce the amount of tumor burden in patients and, in a subset of patients and cancers, achieve long-lasting remission. However, these therapies are often limited by treatment-induced autoimmune adverse events. They affect nearly every organ system, ranging widely from minor rashes and fevers to severe gastrointestinal, pulmonary, or cardiac complications. Dr. Kerry Reynolds, along with Dr. Chloe Villani, and the Massachusetts General Hospital has taken a lead in this arena by altering our clinical practice model to provide expert multi-disciplinary care by creating the Severe Immunotherapy Complications Service. Importantly, this group is not just involved in the clinical care but they have banded together to set up infrastructure to empower specimen collection and facilitate translational research efforts, in order to understand the mechanisms driving immune-related adverse events (irAEs). Blood/tissue samples are systematically collected in an attempt to develop better therapies to treat autoimmune toxicities while maintaining anti-tumor immunity. The hope is that this will further our understanding of early mechanisms leading to autoimmune diseases and identify novel druggable targets with immunosuppressive potential. The Severe Immunotherapy Complications Service brings together expertise from a variety of clinical divisions and scientists across the institution to coordinate our care and tackle a critical problem facing many cancer patients today.
Molina GE, Zubiri L, et al, Reynolds KL. Temporal trends and outcomes among patients admitted for immune-related adverse events: A single-center retrospective cohort study from 2011-2018. Oncologist. 2021 Mar 3.
Schoenfeld SR, Aronow ME, Leaf RK, Dougan M, Reynolds KL. Diagnosis and Management of Rare Immune-Related Adverse Events. Oncologist. Jan 2020;25(1):6-14.
Reynolds KL, Sullivan RJ, Fintelmann FJ, Mansour MK, England J. Case 9-2020: A 64-Year-Old Man with Shortness of Breath, Cough, and Hypoxemia. N Engl J Med. Mar 2020;382(12):1150-1159
Reynolds KL, Guidon AC. Diagnosis and Management of Immune Checkpoint Inhibitor Associated Neurologic Toxicity: Illustrative Case and Review of the Literature. Oncologist. Apr 2019
Additional publications can be found - https://www.massgeneral.org/cancer-center/treatments-and-services/severe-immunotherapy-complications/
- Nov | 5 | 2019
Over the last decade, immunotherapies have increasingly offered hope to thousands of patients with cancer; however, this does not come without its adverse events (AEs), according to Kerry Reynolds, MD.
- May | 18 | 2019
Mass General Cancer Center's Dr. Kerry Reynolds discusses the management of toxicities in an inpatient setting. This video was recorded on May 18, 2019 at the Annual Advances in Cancer Immunotherapy CME Course.
- Mar | 1 | 2019
The challenge of immunotherapy side effects spurs clinicians and researchers at Mass General to find new and better ways to care for cancer patients.
- Nov | 15 | 2019
Massachusetts General Hospital in Boston established its immunotherapy toxicity service care team in part because of the experience of David M., a patient treated there for metastatic melanoma that spread to the lung and brain.
- Dec | 20 | 2019
The Severe Immunotherapy Complications Service at Mass General was created to address the urgent need to understand how and why toxicities occur, in order to develop new therapies that will allow patients to safely stay on their lifesaving immunotherapy regimens.