Dr. Paganoni is an Associate Professor at Harvard Medical School and works as a physician scientist at the Healey Center for ALS at Massachusetts General Hospital and at Spaulding Rehabilitation Hospital.Her research focuses on clinical trials and therapy development for ALS. She has served as PI of several ALS clinical trials and has been using novel trial designs, novel endpoints and digital technology tools to innovate the way investigational products are tested in ALS. She is the co-PI of the HEALEY ALS Platform Trial, the first platform trial for ALS in the world. She recently reported the positive results of the CENTAUR trial and is the co-Chair of the global PHOENIX trial.She is also working with people with Primary Lateral Sclerosis (PLS), a rare form of Motor Neuron Disease, and Hereditary Spastic Paraplegia (HSP). She co-chairs the PLS Task Force and the PLS registry of the Northeast ALS Consortium (NEALS). She is working with other Harvard researchers on developing new assistive technology devices that can improve function and quality of life for people with ALS and other forms of Motor Neuron Disease. Dr. Paganoni published >100 peer-reviewed papers. She is an editorial board member for Muscle and Nerve and the American Journal of PM&R where she is also Associate Editor for the Section Evidence-Based Physiatry/Cochrane Corner. Her research has been funded by the NIH, foundations, and industry. She received several awards for her work including the NIH Rehabilitation Medicine Scientist Training Program Award (2012), the American Academy of Neurology / ALS Association Three-Year Career Development Award in ALS (2017), the American Association of Neuromuscular & Electrodiagnostic Medicine Scientific Impact Award (2019), the Top 10 Clinical Research Achievement Award (2021), and the Martin Prize for Excellence in Clinical Research Award (2021).Dr. Paganoni holds 3 Board Certifications (Physical Medicine and Rehabilitation, Neuromuscular Medicine, and Electrodiagnostic Medicine). She is a member of the Association of Academic Physiatrists (AAP), American Academy of Neurology (AAN), and American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM).
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Sean M. Healey and AMG Center for ALS
55 Fruit Street
Wang Ambulatory Care Center
8th Floor
Boston, MA 02114
Phone: 617-724-3914
Medical Education
American Board Certifications
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This was the best health care experience I have ever had.
Excellent, very understanding
Very professional experience.
She was very thorough in her examination of me, listened to my history and asked questions. Although she did not have all notes from referring doctors, she assured me that she would seek them out to fully evaluate my case in preparation for follow up visit.
She gave me confidence that she is knowledgeable and experienced in this field, something very important to me
Overall very pleased with my visit and the discussed plan of care going forward. Dr. Paganoni was very thorough, knowledgeable and compassionate. I feel I am in the best hands for continued treatment.
Excellent presentation and listening skills. Extremely knowledgeable about my condition and most helpful working out further diagnostic tests and possible future treatments.
Please find a cure for ALS as soon as possible :)
The dr was extremely attentive, caring , knowledgeable and very professional. I have taken the patient to many appointments over the past 10 years and this was the most thorough. A true professional experience.
I've been working with Dr. Paganoni for probably the last year, the better part of the last year. My case has been quite a difficult one to diagnose. I think she's been very clear, very forthright, and very helpful in the whole process. I couldn't ask for more. And her whole group has just been extremely helpful in terms of follow-up. So I would ... Read More