About Alessandro Biffi, MD

Dr. Alessandro Biffi’s practice focuses on identification of individuals at high-risk for brain function impairment, specifically focusing on the interface area between neurological (Alzheimer's disease, vascular dementia) and psychiatric disorders (anxiety, depression). He has spearheaded research efforts aimed at determining individual-level risk for maintenance / loss of cognitive integrity, by combining information derived from clinical observation, neuroimaging and genetic data using state-of-the-art analytical tools. Dr. Biffi currently leads the Aging and Brain Health Research (ABHR) group at Massachusetts General Hospital.

Dr. Biffi on the Mass General Institute for Brain Health

Meet Neurologist Dr. Alessandro Biffi of the Mass General Institute for Brain Health, who shares what the Institute for Brain Health can do for patients, including why preventative brain health is so important and what patients can expect from a visit.

Departments, Centers, & Programs:

Clinical Interests:




Mass General Neurology
55 Fruit St.
Boston, MA 02114
Phone: 855-644-6387

Mass General Neurology: Cognitive Behavioral Neurology Unit
55 Fruit St.
Wang Ambulatory Care Center
Suite 835
Boston, MA 02114
Phone: 617-726-2273

Medical Education

  • MD, University of Milan-Medical School
  • Residency, Brigham and Women's Hospital
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Neurology, American Board of Psychiatry and Neurology

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Dr. Biffi leads the research team in the Aging & Brain Health Research (ABHR) Group, focused on developing new tools to determine individual risk for age-related neurological and psychiatric disorders, and to leverage this information to develop new prevention and treatment interventions.

Neurological and psychiatric disorders affecting the elderly are a major contributor to disability and mortality worldwide. The numbers describing this “epidemic” are truly sobering. One person in three over the age of 65 will develop dementia in their lifetime. Three quarters of the approximately 800,000 strokes diagnosed in the US each year will affect people over the age of 65. One in every fifteen individuals above age 65 suffers from depressive symptoms, with 20% of suicides occurring in this age category. We are committed to ensuring these numbers are drastically reduced over the next few years.

Our Mission: to transform brain aging and health through innovative scientific research.

See our publications at: http://www.ncbi.nlm.nih.gov/sites/myncbi/1jQutYKG9pJAv/bibliography/48653481/public/?sort=date&direction=ascending


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