Study reveals how air pollution may increase the risk of cardiovascular disease
Fine particulate air pollution stimulates production of inflammatory cells, leading to inflammation of the arteries.
Dr. Michael Osborne is a cardiologist at Massachusetts General Hospital, Associate Director of Nuclear Cardiology: Education at Massachusetts General Hospital, and Assistant Professor of Medicine at Harvard Medical School. He graduated summa cum laude with membership in Tau Beta Pi with a degree in biomedical engineering from Vanderbilt University in 2006. He subsequently graduated with honors and membership in the Gold Humanism Honor Society and Alpha Omega Alpha from the University of Chicago Pritzker School of Medicine in 2010. Dr. Osborne completed his internship and residency in internal medicine at the Brigham and Women’s Hospital, Harvard Medical School in 2013. He completed his clinical and research fellowships in cardiovascular medicine and cardiovascular imaging at the Massachusetts General Hospital in 2018.
Dr. Osborne’s research uses advanced cardiovascular imaging techniques, especially positron emission tomography, to investigate the mechanisms linking psychosocial and environmental stressors to cardiometabolic diseases and to identify early markers of cardiovascular risk. In addition, he is interested in using imaging to characterize the impact of interventions on the link between chronic stress and cardiometabolic disease. Beyond his research, Dr. Osborne is a clinician with interests in nuclear cardiovascular imaging and preventive cardiology.
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Cardiometabolic disease has emerged as a growing public health problem across the world. While a large proportion of cardiometabolic disease risk arises from heritable factors and health behaviors, it has hypothesized for years that psychosocial and environmental stressors contribute to the development of these pathologies. Nevertheless, the mechanisms are incompletely defined. Dr. Osborne's research implements advanced cardiovascular imaging, specifically positron emission tomography, to: 1) understand the mechanisms that link psychosocial and environmental stressors to cardiometabolic diseases, 2) identify early markers of cardiometabolic risk, and 3) evaluate the effect of interventions on imaging biomarkers of cardiometabolic diseases.
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Fine particulate air pollution stimulates production of inflammatory cells, leading to inflammation of the arteries.
Una vía biológica que, según se ha descubierto anteriormente, contribuye al impacto del estrés en el riesgo de padecer enfermedades cardiovasculares, también podría ser la base de la mayor incidencia de dichas enfermedades que experimentan las personas de menor nivel socioeconómico.
Mass General investigators have identified a potential mechanism through which long-term exposure to noise leads to inflammation, blood vessel damage, and heart disease.
A biological pathway previously found to contribute to the impact of stress on the risk of cardiovascular disease also may underlie the increased incidence of such disease experienced by individuals with lower socioeconomic status.
Research at the MGH is interwoven throughout more than 30 departments, centers and units and is conducted with the support and guidance of the MGH Research Institute. The Research Roundup is a monthly series highlighting studies, news and events.

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