Childhood obesity is a disease that affects 18 out of every 100 children in the United States. Obesity is a true disease caused by a problem with the body’s hunger and fullness system. Learn more about childhood obesity and how to prevent it.
Sonali Malhotra, MD
Sonali Malhotra, MD
Instructor at Harvard Medical School
Departments, Centers, & Programs:
Mass General for Children: Pediatric Endocrine Program and Diabetes Center
55 Fruit St.
Boston, MA 02114
- MBBS, Indira Gandhi Medical College
- Residency, Lincoln Medical & Mental Health Center
- Fellowship, Maimonides Medical Center
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Pediatric Endocrinology, American Board of Pediatrics
- Pediatrics, American Board of Pediatrics
Accepted Insurance Plans
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Dr. Malhotra has worked on investigating the role of important receptors named “Toll like receptor 2 and 4” (TLR-2 and TLR-4) in the pathogenesis of obesity, insulin resistance, and other obesity related complications in children and adolescents. The results from this study will provide crucial information about the underlying mechanism of how the inflammatory response is triggered in childhood obesity, and how it can lead to complications of childhood obesity.
She is currently collaborating with the Rhythm pharmaceuticals in a study for Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers, the objective of which is to identify individuals with severe, early onset morbid obesity (EOMO), who are suspected to have mutations in the POMC, PCSK1 or LepR gene, leading to clinical presentation of Melanocortin 4 (MC4R) pathway deficiency obesity.
Other areas of her research include elucidating anti-neoplastic treatment effectiveness in cancer patients with concomitant obesity.
Dr. Malhotra published the pioneer study examining the effects of current marijuana use on thyroid function and autoimmunity in human subjects. The study reported that current marijuana use, in short term, is associated with lower levels of thyroid stimulating hormone (TSH), which is the key regulatory hormone controlling the thyroid gland. In lines with these pivotal findings several studies are in process of further investigating the prospective effects of marijuana use on the various other hormonal axes in humans.
Malhotra S, Heptulla RA, Homel P, Motaghedi R: Effect of Marijuana Use on Thyroid Function and Autoimmunity. Thyroid: official journal of the American Thyroid Association 2017, 27(2):167-173.
Ghanny BA, Malhotra S, Kumta S, Kazachkova I, Homel P, Jacobson-Dickman E, Motaghedi R. Should children with isolated premature adrenarche be routinely evaluated for non-classical congenital adrenal hyperplasia? J Pediatr Endocrinol Metab. 2015 Dec 7
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