Drugs that inhibit the protein expressed by a mutated form of the KRAS gene might soon be approved, but cancer cells often develop additional mutations that make them resist such targeted drugs. Investigators have identified some of these mutations in a patient and strategies to overcome them.
Departments, Centers, & Programs:
Mass General Hospital Cancer Center
55 Fruit Street
Boston, MA 02114-2696
- MD, University of Massachusetts Medical School
- Residency, Brigham and Women's Hospital
- Fellowship, Beth Israel Deaconess Medical Center
American Board Certifications
- Medical Oncology, American Board of Internal Medicine
- Internal Medicine, American Board of Internal Medicine
- Hematology, American Board of Internal Medicine
Accepted Insurance Plans
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Dr. Klempner's research is focused on identifying molecular subgroups in gastric and esophageal cancers and translating this information to new treatment approaches for these difficult cancers. He has interests in circulating tumor DNA, cancer biomarkers, and peritoneal disease and ascites in GI cancers.
Klempner SJ, Madison R, Pujara V, Ross JS, Miller VA, Ali SM, Schrock AB, Kim ST, Maron SB, Dayyani F, Catenacci DVT, Lee J, Chao J. FGFR2-Altered Gastroesophageal Adenocarcinomas Are an Uncommon Clinicopathologic Entity with a Distinct Genomic Landscape. Oncologist. 2019 Jun 27;. doi: 10.1634/theoncologist.2019-0121.
Klempner SJ, Maron SB, Chase L, Lomnicki S, Wainberg ZA, Catenacci DVT. Initial Report of Second-Line FOLFIRI in Combination with Ramucirumab in Advanced Gastroesophageal Adenocarcinomas: A Multi-Institutional Retrospective Analysis.Oncologist. 2019 Apr;24(4):475-482.
Schrock AB, Pavlick D, Klempner SJ, Chung JH, Forcier B, Welsh A, Young L, Leyland-Jones B, Bordoni R, Carvajal RD, Chao J, Kurzrock R, Sicklick JK, Ross JS, Stephens PJ, Devoe C, Braiteh F, Ali SM, Miller VA. Hybrid Capture-Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus. Clin Cancer Res. 2018 Apr 15;24(8):1881-1890.