About Kristopher Kahle, MD, PhD

Dr. Kahle is the Director of Pediatric Neurosurgery at the Massachusetts General Hospital (MGH) and the Harvard Center for Hydrocephalus and Neurodevelopmental Disorders (HAND). He is a board-certified pediatric neurosurgeon, with experience in a broad range of pediatric neurosurgical disorders including brain and spinal cord tumors and cysts, all types of hydrocephalus, Chiari malformation, spina bifida, vascular malformations, and others. He also treats these conditions in transitional age patients and adults, providing continuity of care across the age spectrum. He is highly skilled in both open and endoscopic/minimally invasive neurosurgical techniques.

Dr. Kahle is a fellow of the American Association of Neurological Surgeons (AANS) and a member of numerous medical organizations, including the AANS, Congress of Neurological Surgeons (CNS), American Society of Pediatric Neurosurgeons (ASPN), and the International Society of Pediatric Neurosurgeons (ISPN).

Dr. Kahle graduated cum laude from the University of Chicago in 1999 with degrees in Biology and Philosophy. He received his M.D. from Yale School of Medicine in 2007, where he also received his Ph.D. working in the laboratory of human geneticist Richard Lifton. He completed his neurosurgery residency training at MGH in 2014, as well as a post-doctoral research fellowship at Harvard University with co-mentors Stephen Elledge and David Clapham. He completed a clinical pediatric neurosurgery fellowship at Boston Children’s Hospital, where he was Shellito staff associate and Instructor of Neurosurgery at Harvard Medical School. Dr. Kahle returned to New Haven to join the Yale School of Medicine faculty, where he was Assistant Professor of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology, and Director of Neonatal and Congenital Anomaly Neurosurgery from 2016-2021. 

Clinical Interests:



Mass General Neurosurgery
55 Fruit St.
Wang Ambulatory Care Center
Suite 331
Boston, MA 02114
Phone: 617-643-9175

Medical Education

  • MD, Yale University School of Medicine
  • Residency, Massachusetts General Hospital
  • Fellowship, Boston Children's Hospital

American Board Certifications

  • Neurosurgery, American Board of Neurological Surgery

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Dr. Kahle’s NIH-funded lab at Harvard is focused on elucidating the human genetics and molecular mechanisms of pediatric neurosurgical conditions, and translating these insights into improved care for patients. His lab has received international recognition for discovering multiple novel human disease genes, including those causing congenital hydrocephalus, vein of Galen aneurysmal malformation, moyamoya disease, and others. The lab has a particular interest and expertise in the development of the brain's ventricular system, the function of the choroid plexus epithelium, and mechanisms of cerebrospinal fluid homeostasis. His lab's findings are shifting paradigms of disease pathophysiology, and increasing precision in diagnosis, prognostication, and treatment stratification. 


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