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Multi-modality Imaging of Atherosclerotic Plaques
The majority of myocardial infarctions and sudden cardiac death result from the rupture of plaques which, in most cases, did not cause significant flow limitation prior to the acute event. While stenosis severity (measured with techniques such as angiography and stress testing), is the gold standard for characterization of atherosclerotic disease, it has proven a poor predictor of therapeutic efficacy and a coarse predictor of risk. Novel methods for the characterization of plaques are needed. Accordingly, the focus of Dr Tawako?s laboratory is to develop, validate, and apply novel imaging methods to non-invasively characterize atherosclerotic plaques, with a focus on plaque inflammation.
To that end, Dr Tawakol's group has developed and validated methods using positron emission tomography that enables the non-invasive measurement of plaque inflammation in patients. Currently, Dr Tawakol leads several multi-center trials that are evaluating the efficacy of novel drugs for reducing plaque inflammation.
A biological pathway previously found to contribute to the impact of stress on the risk of cardiovascular disease also may underlie the increased incidence of such disease experienced by individuals with lower socioeconomic status.
Ahmed Tawakol, MD, co-director of the Cardiac MR PET CT Program, discusses the link between stress and atherosclerotic disease, and his team’s work using multimodality imaging to better understand that risk
A team of clinicians led by Ahmed A. Tawakol MD co-director Cardiac MR PET CT Program has found a novel pathway linking psychosocial stress to heart disease.
Statistical analyses of correlated imaging scans and cardiovascular event data shows amygdalar activity significantly associated with arterial inflammation, increased bone-marrow activity and risk of cardiovascular disease events
Mass General physicians presented on the podium moderated sessions or showcased posters over 50 times at the American Heart Association 2017 Scientific Sessions.
For the first time, an MGH study has identified a link between activity in one part of the brain to episodes in the heart.
A study led by Massachusetts General Hospital and Icahn School of Medicine at Mount Sinai investigators has linked, for the first time in humans, activity in a stress-sensitive structure within the brain to the risk of subsequent cardiovascular disease.
New data showing that high-dose atorvastatin can reduce periodontal inflammation in as little as four weeks suggests a new mechanism of action for statins.
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