Anthony Laboratory: Robert Anthony, PhD
The Anthony Laboratory at Massachusetts General Hospital investigates the role and regulation of immunoglobulin glycosylation.
Mailcode CNY 149-8
Building 149, 13th Street
Charlestown, MA 02129
Antibodies are the preeminent effector proteins of the immune system. The bimodal activity of antibodies allows simultaneous recognition of antigen (by the antigen-binding fragment, Fab) with high affinity, and recruitment and activation of leukocytes through interactions between the constant, crystallizable fragment (Fc) and Fc receptors (FcRs) expressed by innate immune cells. Studies have demonstrated that antibody glycosylation is an important regulator of Fc-FcR interactions. The Anthony Laboratory at Massachusetts General Hospital is particularly interested in the role and regulation of IgE and IgG glycosylation in health and disease.
Robert Anthony, PhD
Associate Investigator, Center for Immunology and Inflammatory Diseases, Mass General Research Institute
Associate Professor of Medicine, Harvard Medical School