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Overview

Antibodies are the preeminent effector proteins of the immune system. The bimodal activity of antibodies allows simultaneous recognition of antigen (by the antigen-binding fragment, Fab) with high affinity, and recruitment and activation of leukocytes through interactions between the constant, crystallizable fragment (Fc) and Fc receptors (FcRs) expressed by innate immune cells. Studies have demonstrated that antibody glycosylation is an important regulator of Fc-FcR interactions. The Anthony Laboratory at Massachusetts General Hospital is particularly interested in the role and regulation of IgE and IgG glycosylation in health and disease.

Research Projects

  • The Role and Regulation of IgE Glycosylation in Allergy
  • The Role and Regulation of IgG Glycosylation in Homeostasis and Disease

Publications

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Meet Our Team

Robert Anthony, PhD

Robert Anthony, PhD
Associate Investigator, Center for Immunology and Inflammatory Diseases, Mass General Research Institute
Associate Professor of Medicine, Harvard Medical School